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1. Virological Surveillance of Dengue in Saint Martin and Saint Barthélemy, French West Indies, Using Blood Samples on Filter Paper

Author

Séverine Matheus, Alain Winicki, Patricia Huc-Anais, Laetitia Bremand, Franck Berger, Philippe Quénel, Philippe Dussart, Sylvie Cassadou, Bhetty Labeau, J. L. Chappert, Centre National de Référence pour les Arbovirus - Laboratoire de Virologie [Cayenne, Guyane française] (CNR - laboratoire associé), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Cellule Interrégionale d'Epidémiologie Antilles-Guyane, Cellule interrégionale d'épidémiologie Antilles-Guyane [CIRE], Réseau International des Instituts Pasteur (RIIP), Laboratoire d'Analyses Médicales, and This study was supported by the Conseil Régional de la Guyane (agreement no. 60/2007/CR). The laboratory of virology, as National Reference Center, receives financial support from Institut Pasteur and Institut de Veille Sanitaire.

Subjects
Male, MESH: Blood Specimen Collection, MESH: Dengue, Dengue virus, MESH: Dengue Virus, medicine.disease_cause, Dengue fever, Dengue, 0302 clinical medicine, MESH: Reverse Transcriptase Polymerase Chain Reaction, Prospective Studies, 030212 general & internal medicine, West indies, Blood Specimen Collection, Caribbean island, Reverse Transcriptase Polymerase Chain Reaction, Articles, Saint Barthelemy, 3. Good health, Infectious Diseases, Population Surveillance, Female, MESH: Paper, Paper, Financial costs, MESH: West Indies, West Indies, 030231 tropical medicine, Early detection, Sensitivity and Specificity, MESH: Population Surveillance, 03 medical and health sciences, Virology, Environmental health, medicine, Humans, Serotyping, MESH: Humans, business.industry, MESH: Serotyping, Dengue Virus, medicine.disease, MESH: Sensitivity and Specificity, MESH: Male, MESH: Prospective Studies, MESH: Filtration, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Parasitology, business, MESH: Female, Filtration
Abstract

International audience; To strengthen active dengue surveillance in Saint Martin and Saint Barthélemy, two French Caribbean islands, we evaluated the epidemiological usefulness of collecting blood samples from NS1-positive dengue patients on filter paper to identify the dengue serotypes circulating in these regions during a 27-month period. This approach allowed dengue serotypes to be identified by reverse transcriptase-polymerase chain reaction in 90.1% of the total set of 666 samples analyzed and, in 95.5% of the samples collected during the acute phase of the disease. This prospective virological surveillance using blood samples absorbed onto filter paper, which were stored at 4°C and shipped at ambient temperature to a specialized laboratory for analysis, allowed us to avoid the logistic and financial costs associated with shipping frozen venous blood samples. This surveillance system offers a low-cost alternative for reinforcing dengue prevention in areas where specialized laboratories do not exist, notably by facilitating the early detection of potentially new dengue serotypes.

Published
2012
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2. Giant axonal neuropathy: clinical and genetic study in six cases

Author

Sevim Erdem, Gülşen Köse, L. Cavalier, Michel Koenig, Ercan Demir, Pascale Bomont, Haluk Topaloglu, Pascale Guicheney, S Muftuoglu, Sabiha Aysun, Mehmet Demirci, Meral Topçu, E Tan, A N Cakar, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Çocuk Sağlığı ve Hastalıkları

Subjects
Male, Pathology, Genetic Linkage, Biopsy, DNA Mutational Analysis, Gene mutation, MESH: Magnetic Resonance Imaging, MESH: Biopsy, 0302 clinical medicine, Mutation Carrier, MESH: Child, MESH: DNA Mutational Analysis, Child, Skin, Giant axonal neuropathy, Psychiatry, 0303 health sciences, Gigaxonin, MESH: Genetic Heterogeneity, Electroencephalography, Magnetic Resonance Imaging, Pedigree, 3. Good health, Psychiatry and Mental health, Phenotype, medicine.anatomical_structure, Child, Preschool, Female, medicine.symptom, Paper, MESH: Axons, medicine.medical_specialty, MESH: Demyelinating Diseases, Neuromuscular disease, Adolescent, MESH: Pedigree, Biology, MESH: Phenotype, MESH: Electromyography, White matter, Genetic Heterogeneity, 03 medical and health sciences, MESH: Skin, Sural Nerve, MESH: Electroencephalography, medicine, Humans, Point Mutation, MESH: Point Mutation, 030304 developmental biology, MESH: Adolescent, MESH: Humans, Cerebellar ataxia, Electromyography, MESH: Child, Preschool, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, MESH: Haplotypes, medicine.disease, MESH: Male, Axons, MESH: Sural Nerve, Peripheral neuropathy, Haplotypes, Surgery, Neurosciences & Neurology, MESH: Microsatellite Repeats, Neurology (clinical), MESH: Female, MESH: Linkage (Genetics), MESH: Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 16, 030217 neurology & neurosurgery, Demyelinating Diseases, Microsatellite Repeats
Abstract

International audience; BACKGROUND: Giant axonal neuropathy (GAN) is a severe recessive disorder characterised by variable combination of progressive sensory motor neuropathy, central nervous system (CNS) involvement, and "frizzly" hair. The disease is caused by GAN gene mutations on chromosome 16q24.1. AIMS: To search for GAN gene mutations in Turkish patients with GAN and characterise the phenotype associated with them. METHODS: Linkage and mutation analyses were performed in six affected patients from three consanguineous families. These patients were also investigated by cranial magnetic resonance imaging (MRI) and electroencephalography (EEG). Electromyography (EMG) was performed in heterozygous carriers from family 1 and family 3. RESULTS: Linkage to 16q24.1 was confirmed by haplotype analysis. GAN mutations were identified in all families. Family 1 had the R293X mutation, previously reported in another Turkish family. Families 2 and 3, originating from close geographical areas, shared a novel mutation, 1502+1G>T, at the donor splice site of exon 9. All patients displayed a common phenotype, including peripheral neuropathy, cerebellar ataxia, and frizzly hair. Cranial MRI showed diffuse white matter abnormalities in two patients from family 1 and the patient from family 3, and minimal white matter involvement in the patient from family 2. EMG of a heterozygous R293X mutation carrier showed signs of mild axonal neuropathy, whereas a 1502+1G>T mutation carrier had normal EMG. EEG abnormalities were found in three patients. CONCLUSION: These findings highlight the association of CNS involvement, in particular white matter abnormalities, with peripheral neuropathy in GAN. The phenotypical consequences of both mutations (when homozygous) were similar.

Published
2005
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3. Use of filter paper as a transport medium for laboratory diagnosis of cholera under field conditions

Author

Kathryn P. Alberti, Vital Mondongue, Anne-Laure Page, Marie-Laure Quilici, Philippe J Guerin, Alain Guénolé, Sylvaine Lonlas Mayele, Epicentre [Paris] [Médecins Sans Frontières], Centre National de Référence des Vibrions et du Choléra - National Reference Center Vibrios and Cholera (CNR), Institut Pasteur [Paris] (IP), Ministry of Health, Ministery of Health, Médecins sans Frontières (MSF), Médecins Sans Frontières Belgique, Nuffield Department of Clinical Medicine [Oxford], University of Oxford, This study was supported by grants from Médecins Sans Frontières, the French Institute for Public Health Surveillance, and the Institut Pasteur, Institut Pasteur [Paris], and University of Oxford [Oxford]

Subjects
Microbiology (medical), Adult, Male, Paper, [SDV]Life Sciences [q-bio], 030231 tropical medicine, MESH: Bacteriological Techniques, Biology, medicine.disease_cause, Microbiology, Specimen Handling, 03 medical and health sciences, Feces, 0302 clinical medicine, MESH: Cholera, Cholera, Transport medium, medicine, Humans, MESH: Specimen Handling, Vibrio cholerae, 0303 health sciences, Bacteriological Techniques, MESH: Middle Aged, MESH: Humans, Filter paper, 030306 microbiology, MESH: Feces, MESH: Adult, Bacteriology, Middle Aged, medicine.disease, MESH: Male, MESH: Paper, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Biochemical engineering, MESH: Female, Limited resources, MESH: Vibrio cholerae, Field conditions
Abstract

Confirmation of a cholera epidemic is based on bacteriological identification of the agent and requires the sending of samples to a culture laboratory, often in countries with limited resources. Comparison of the use of filter paper with the use of Cary-Blair reference medium for stool transport showed that this simple transport medium is appropriate for the recovery of Vibrio cholerae .

Published
2011
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4. Perception of longitudinal body axis in patients with stroke: a pilot study

Author

Julien Barra, V. Chauvineau, Théophile Ohlmann, Dominic Pérennou, Michael A. Gresty, Bases Génétiques, Moléculaires et Cellulaires du Développement (BGMCD), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Paper, medicine.medical_specialty, MESH: Gravity Sensing, Supine position, media_common.quotation_subject, MESH: Space Perception, MESH: Stroke, 050105 experimental psychology, Neglect, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Orientation (mental), Perception, medicine, 0501 psychology and cognitive sciences, MESH: Functional Laterality, Stroke, MESH: Body Image, MESH: Perceptual Disorders, media_common, MESH: Aged, MESH: Humans, MESH: Middle Aged, 05 social sciences, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, MESH: Posture, Sensory loss, medicine.disease, MESH: Case-Control Studies, MESH: Male, Surgery, Psychiatry and Mental health, Coronal plane, Neurology (clinical), Perceptual Disorders, Psychology, MESH: Female, 030217 neurology & neurosurgery
Abstract

International audience; BACKGROUND AND AIMS: To investigate the hypothesis that patients with a hemisphere stroke may perceive their longitudinal body axis (LBA) rotated in the frontal plane. This error in an egocentric frame of reference could be detrimental to posture, as tilted LBA would imply an unequal distribution of body mass about the true vertical. METHOD: 26 healthy subjects matched in age with 18 patients living with stroke participated in the study. The 18 patients were tested on average 80 days after a first left (n = 8) or right (n = 10) hemisphere stroke. Participants perceived their LBA by adjustments of the orientation of a luminous rod pivoting around a dorsonavel axis to the subjective direction of LBA. Participants were studied in the supine position to dissociate somaesthetic cues from graviceptive cues. RESULTS: Patients with stroke perceived their LBA rotated to the contralesional side in comparison with controls (p = 0.004). For all controls and 10 patients with stroke, the perceived LBA was very close to true LBA (mean (SD) 0.24 degrees (1.31 degrees)). For eight patients with stroke (six right stroke, two left stroke), the perceived LBA was rotated from true body orientation in the direction opposite to the lesioned side (range 3-9.5 degrees, mean 5.2 degrees). These eight patients provided similar estimates by tactile manipulation of the rod (without vision). The rotation of perceived LBA was more pronounced for right-hemisphere strokes. The magnitudes of perceptual rotations correlated with sensory loss, signs of spatial neglect and the degree of postural and gait disability. CONCLUSION: This is the first study showing that certain patients with a hemisphere stroke perceive their LBA rotated to the contralesional side. The consequences for perceptuomotor coordination have implications for their postural disorders.

Published
2006
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5. Placebo controlled, randomised, double blind study of the effects of botulinum A toxin on detrusor sphincter dyssynergia in multiple sclerosis patients

Author

Benoit Nicolas, Philippe Gallien, Eric Bellissant, Jean Michel Reymann, Gérard Amarenco, M. de Sèze, Laboratoire de Cristallographie et modélisation des matériaux minéraux et biologiques (LCM3B), Université Henri Poincaré - Nancy 1 (UHP)-Centre National de la Recherche Scientifique (CNRS), Physiologie et physiopathologie de la motricité chez l'homme, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des images et des signaux (LIS), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en gestion (CRG), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Mouvement Adaptation Cognition (MAC), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Cristallographie et modélisation des matériaux minéraux et biologiques ( CMMMB ), Université Henri Poincaré - Nancy 1 ( UHP ) -Centre National de la Recherche Scientifique ( CNRS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IFR70-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de Chimie des Substances Naturelles ( ICSN ), Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des images et des signaux ( LIS ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National Polytechnique de Grenoble ( INPG ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de recherche en gestion ( CRG ), École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Mouvement Adaptation Cognition ( MAC ), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique ( CNRS ), Centre d'Investigation Clinique [Rennes] ( CIC ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut National Polytechnique de Grenoble (INPG)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, MESH : Neuromuscular Agents, MESH : Multiple Sclerosis, 030232 urology & nephrology, urologic and male genital diseases, law.invention, Placebos, 0302 clinical medicine, Randomized controlled trial, law, MESH : Female, MESH: Double-Blind Method, Botulinum Toxins, Type A, Alfuzosin, MESH: Treatment Outcome, Urinary bladder, MESH: Middle Aged, MESH : Botulinum Toxin Type A, Middle Aged, female genital diseases and pregnancy complications, 3. Good health, Psychiatry and Mental health, medicine.anatomical_structure, Treatment Outcome, Neuromuscular Agents, MESH : Urination Disorders, MESH: Botulinum Toxin Type A, Female, medicine.symptom, Detrusor sphincter dyssynergia, medicine.drug, Paper, medicine.medical_specialty, Multiple Sclerosis, MESH: Urinary Bladder, Neurogenic, MESH : Male, Urology, MESH: Placebos, MESH : Treatment Outcome, Placebo, MESH : Urodynamics, 03 medical and health sciences, Double-Blind Method, medicine, Humans, MESH : Double-Blind Method, MESH : Placebos, MESH : Middle Aged, Urinary Bladder, Neurogenic, MESH: Urodynamics, MESH: Humans, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, business.industry, Urinary retention, urogenital system, MESH : Humans, Urination disorder, MESH: Multiple Sclerosis, Urination Disorders, MESH : Urinary Bladder, Neurogenic, MESH: Male, Surgery, Urodynamics, MESH: Urination Disorders, MESH: Neuromuscular Agents, Sphincter, Neurology (clinical), [ SDV.BA.MVSA ] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, business, MESH: Female, 030217 neurology & neurosurgery
Abstract

International audience; OBJECTIVE: The purpose of the study was to evaluate the efficacy and safety of botulinum A toxin in the treatment of detrusor sphincter dyssynergia in multiple sclerosis patients. METHODS: This was a multicentre, placebo controlled, randomised, double blind study. Patients with chronic urinary retention were included if they had post-voiding residual urine volume between 100 and 500 ml. They received a single transperineal injection of either botulinum A toxin (100 U Allergan) or placebo in the sphincter and also 5 mg slow release alfuzosin bid over 4 months. Main endpoint was post-voiding residual urine volume assessed 1 month after injection. Follow up duration was 4 months. Statistical analysis was performed using a sequential method, the triangular test. RESULTS: The study was stopped after the fourth analysis (86 patients had been included: placebo: 41, botulinum A toxin: 45). At inclusion, there was no significant difference between groups whichever variable was considered. Mean (standard deviation) post-voiding residual urine volume was 217 (96) and 220 (99) ml in placebo and botulinum A toxin groups, respectively. One month later, post-voiding residual urine volume was 206 (145) and 186 (158) ml (p = 0.45) in placebo and botulinum A toxin groups, respectively. However, compared to placebo, botulinum A toxin significantly increased voiding volume (+54%, p = 0.02) and reduced pre-micturition (-29%, p = 0.02) and maximal (-21%, p = 0.02) detrusor pressures. Other secondary urodynamic endpoints and tolerance were similar in the two groups. CONCLUSIONS: In multiple sclerosis patients with detrusor sphincter dyssynergia, a single injection of botulinum A toxin (100 U Allergan) does not decrease post-voiding residual urine volume.

Published
2005
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6. Longitudinal thalamic diffusion changes after middle cerebral artery infarcts

Author

Denis LeBihan, Sabina Pappatà, Marie-Germaine Bousser, Dominique Hervé, Nicolas Molko, Hugues Chabriat, F. Buffon, Transduction du Signal et Plasticite Dans Le Systeme Nerveux, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service Hospitalier Frédéric Joliot (SHFJ), National Institutes of Health [Bethesda] (NIH), Human Brain Research Center [Kyoto] (HBRC), Kyoto University [Kyoto], Service de neurologie [Univ. Paris VII], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Kyoto University, and Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Paper, medicine.medical_specialty, Pathology, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, medicine.medical_treatment, Thalamus, MESH: Diffusion Magnetic Resonance Imaging, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine.artery, Internal medicine, Fractional anisotropy, Medicine, cardiovascular diseases, Cerebral infarcts, MESH: Longitudinal Studies, Stroke, MESH: Aged, MESH: Thalamus, MESH: Humans, MESH: Middle Aged, business.industry, MESH: Infarction, Middle Cerebral Artery, MESH: Adult, medicine.disease, MESH: Male, Highly sensitive, Psychiatry and Mental health, Middle cerebral artery, Cardiology, cardiovascular system, Surgery, MESH: Neuroglia, MESH: Disease Progression, Neurology (clinical), sense organs, business, Stroke recovery, MESH: Female, 030217 neurology & neurosurgery, Diffusion MRI
Abstract

International audience; BACKGROUND: Cerebral infarcts are responsible for functional alterations and microscopic tissue damage at distance from the ischaemic area. Such remote effects have been involved in stroke recovery. Thalamic hypometabolism is related to motor recovery in middle cerebral artery (MCA) infarcts but little is known concerning the tissue changes underlying these metabolic changes. Diffusion tensor imaging (DTI) is highly sensitive to microstructural tissue alterations and can be used to quantify in vivo the longitudinal microscopic tissue changes occurring in the thalamus after MCA infarcts in humans. METHODS: Nine patients underwent DTI after an isolated MCA infarct. Mean diffusivity (MD), fractional anisotropy (FA), and thalamic region volume were measured from the first week to the sixth month after stroke onset in these patients and in 10 age matched controls. RESULTS: MD significantly increased in the ipsilateral thalamus between the first and the sixth month (0.766 x 10(-3) mm(2)/s first month; 0.792 x 10(-3) mm(2)/s third month; 0.806 x 10(-3) mm(2)/s sixth month). No significant modification of FA was detected. In six patients, the ipsilateral/contralateral index of MD was higher than the upper limit of the 95% CI calculated in 10 age matched controls. An early decrease of MD preceded the increase of ipsilateral thalamic diffusion in one patient at the first week and in two other patients at the first month. CONCLUSION: After MCA infarcts, an increase in diffusion is observed with DTI in the ipsilateral thalamus later than 1 month after the stroke onset. This is presumably because of the progressive loss of neurons and/or glial cells. In some patients, this increase is preceded by a transient decrease in diffusion possibly related to an early swelling of these cells or to microglial activation. Further studies in larger series are needed to assess the clinical correlates of these findings.

Published
2005
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7. Bilateral hemispheric alteration of memory processes in right medial temporal lobe epilepsy

Author

Dominique Hasboun, Yves Samson, S. Dupont, Séverine Samson, Pierre-Francois Van de Moortele, Michel Baulac, Jean-Baptiste Poline, D. Le Bihan, Écologie fonctionnelle et physique de l'environnement (EPHYSE), Institut National de la Recherche Agronomique (INRA), Institut de recherche sur la biologie de l'insecte UMR7261 (IRBI), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Cultures et Sociétés en Europe (CSE), Université Marc Bloch - Strasbourg II-Centre National de la Recherche Scientifique (CNRS), Service de Physique des Matériaux et Microstructures (SP2M - UMR 9002), Institut Nanosciences et Cryogénie (INAC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service NEUROSPIN (NEUROSPIN), IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Human Brain Research Center [Kyoto] (HBRC), Kyoto University, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Cortex et Epilepsie [Paris], Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de Tours-Centre National de la Recherche Scientifique (CNRS), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Kyoto University [Kyoto], Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Écologie fonctionnelle et physique de l'environnement (EPHYSE - UR1263), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], CHU Pitié-Salpêtrière [APHP]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Grenoble Alpes (UGA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP], Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
Male, genetic structures, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Audiology, Electroencephalography, Functional Laterality, MESH: Magnetic Resonance Imaging, Epilepsy, 0302 clinical medicine, MESH: Middle Aged, medicine.diagnostic_test, 05 social sciences, Cognitive disorder, Brain, MESH: Cerebrovascular Circulation, Middle Aged, MESH: Memory Disorders, Magnetic Resonance Imaging, Psychiatry and Mental health, Cerebrovascular Circulation, MESH: Epilepsy, Temporal Lobe, Female, Psychology, Adult, Paper, medicine.medical_specialty, MESH: Hemodynamics, Adolescent, behavioral disciplines and activities, 050105 experimental psychology, Lateralization of brain function, Temporal lobe, 03 medical and health sciences, MESH: Brain, MESH: Electroencephalography, medicine, Humans, 0501 psychology and cognitive sciences, Memory disorder, MESH: Functional Laterality, MESH: Adolescent, Memory Disorders, MESH: Humans, Recall, Hemodynamics, MESH: Adult, medicine.disease, MESH: Male, Epilepsy, Temporal Lobe, Surgery, Neurology (clinical), Verbal memory, Neuroscience, MESH: Female, 030217 neurology & neurosurgery
Abstract

International audience; OBJECTIVE: Functional MRI (fMRI ) was used to investigate right medial temporal lobe epilepsy (RTLE) effects on verbal memory. METHODS: BOLD fMRI data were collected from seven right sided MTLE patients (RTLE) and compared with the data previously acquired from seven left sided MTLE patients (LTLE) and 10 control subjects. Twenty two contiguous images covering the whole brain were acquired using an EPI echoplanar sequence. Subjects were instructed to learn a list of 17 words, and to recall it immediately and at 24 hours interval. Group analyses were performed using SPM96. RESULTS: RTLE patients retrieval performances were significantly impaired as compared with the performance of control subjects. As compared with control subjects and LTLE patients, RTLE patients exhibited a different pattern of hemispheric activations and a global decrease in left hemisphere functional activity. CONCLUSION: MTLE cannot be considered as a model of pure well lateralised hippocampal dysfunction. The verbal memory impairment depicted in RTLE patients may be considered as the witness of a bilateral impairment of the neuroanatomical circuits subserving memory.

Published
2002