1. Body fat distribution in Parkinson's disease: An MRI-based body fat quantification study
- Author
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Jan Kassubek, Albert C. Ludolph, Hans-Peter Müller, Denise Bernhardt, Luc Dupuis, University of Ulm (UUlm), Heidelberg Institute of Radiation Oncology [Heidelberg, Germany] (HIRO), Heidelberg University Hospital [Heidelberg], Mécanismes Centraux et Périphériques de la Neurodégénérescence, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Dieterle, Stéphane
- Subjects
Leptin ,Male ,Parkinson's disease ,[SDV]Life Sciences [q-bio] ,Statistics as Topic ,Adipose tissue ,Gastroenterology ,Weight loss ,Body Mass Index ,MESH: Magnetic Resonance Imaging ,[SCCO]Cognitive science ,0302 clinical medicine ,MESH: Sequestosome-1 Protein ,Image Processing, Computer-Assisted ,Medicine ,Mass index ,030212 general & internal medicine ,MESH: Statistics, Nonparametric ,medicine.diagnostic_test ,MESH: Peptides ,Parkinson Disease ,MESH: Follow-Up Studies ,MESH: Case-Control Studies ,MESH: Image Processing, Computer-Assisted ,[SDV] Life Sciences [q-bio] ,Adipose Tissue ,Neurology ,Female ,medicine.symptom ,MESH: Adipose Tissue ,medicine.medical_specialty ,Body fat distribution ,MESH: Zebrafish Proteins ,Statistics, Nonparametric ,MESH: Protein-Serine-Threonine Kinases ,MESH: Body Mass Index ,03 medical and health sciences ,Magnetic resonance imaging ,Internal medicine ,Humans ,MESH: Body Fat Distribution ,MESH: Zebrafish ,MESH: Statistics as Topic ,MESH: Humans ,MESH: Phosphorylation ,business.industry ,Body Weight ,Case-control study ,[SCCO] Cognitive science ,MESH: Leptin ,medicine.disease ,MESH: Male ,MESH: Body Weight ,Endocrinology ,Metabolism ,Case-Control Studies ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Body mass index ,MESH: Female ,030217 neurology & neurosurgery ,MESH: Parkinson Disease ,Follow-Up Studies - Abstract
International audience; Introduction: There is some evidence that Parkinson's Disease (PD) patients have lower body weight and lower fat mass when compared to healthy subjects and that lower body weight and fat mass influence disease risk and progression. It remains unclear, however, if weight loss of fat mass loss occurs only in a subgroup of patients and whether fat distribution is altered during PD. The aim of this study was to prospectively investigate adipose tissue content and distribution in PD patients.Methods: The body fat composition of PD patients (N = 54) was compared with age matched healthy controls (N = 55) using a magnetic resonance imaging (MRI)-based method. A longitudinal MRI scan was acquired in 25 PD patients after a mean follow up period of 12 months.Results: The volume of total body fat as well as of visceral fat showed no difference between PD patients and healthy controls at baseline or at follow up. However, PD patients displayed decreased subcutaneous fat tissue (p = 0.01) and a higher visceral to subcutaneous fat ratio as compared to controls (p = 0.004). After follow up, 16 PD patients did not lose weight, while 9 PD patients lost between 0.5 and 10 kg.Conclusion: Fat distribution is altered in PD patients, with an increased ratio of visceral to subcutaneous fat.
- Published
- 2016