1. Mesoporous Silica Nanoparticles for Co-Delivery of Drugs and Nucleic Acids in Oncology: A Review
- Author
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Paris, Juan L., Vallet-Regí, María, [Paris,JL] Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Civil, Málaga, Spain. [Paris,JL] Nanostructures for Diagnosing and Treatment of Allergic Diseases Laboratory, Andalusian Center for Nanomedicine and Biotechnology-BIONAND, Málaga, Spain. [Vallet-Regí,M] Departamento de Química en Ciencias Farmacéuticas (Unidad Docente de Química Inorgánica y Bioinorgánica), Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. [Vallet-Regí,M] Centro de Investigación Biomédicaen Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain., This paper was funded by the European Research Council (Grant VERDI, and ERC-2015 AdG no. 694160). J.L.P. was supported by a Sara Borrell research contract from the Institute of Health ‘Carlos III’ of the Ministry of Science and Innovation (grant cofounded by European Social Fund (ESF), reference CD19/00250CP15/00103).
- Subjects
Mesoporous silica nanoparticles ,Nanopartículas ,Co-delivery ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Transfer Techniques [Medical Subject Headings] ,Gene transfection ,Transfección ,Chemicals and Drugs::Inorganic Chemicals::Minerals::Silicon Dioxide [Medical Subject Headings] ,Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids [Medical Subject Headings] ,Nucleic acids ,Nanomedicine ,Sistemas de liberación de medicamentos ,Drug delivery ,Nanomedicina ,Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic::Transfection [Medical Subject Headings] ,Disciplines and Occupations::Natural Science Disciplines::Nanotechnology::Nanomedicine [Medical Subject Headings] ,Ácidos nucleicos ,Dióxido de silicio ,Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Delivery Systems [Medical Subject Headings] - Abstract
Mesoporous silica nanoparticles have attracted much attention in recent years as drug and gene delivery systems for biomedical applications. Among their most beneficial features for biomedicine, we can highlight their biocompatibility and their outstanding textural properties, which provide a great loading capacity for many types of cargos. In the context of cancer nanomedicine, combination therapy and gene transfection/silencing have recently been highlighted as two of its most promising fields. In this review, we aim to provide an overview of the different small molecule drug-nucleic acid co-delivery combinations that have been developed using mesoporous silica nanoparticles as carriers. By carefully selecting the chemotherapeutic drug and nucleic acid cargos to be co-delivered by mesoporous silica nanoparticles, different therapeutic goals can be achieved by overcoming resistance mechanisms, combining different cytotoxic mechanisms, or providing an additional antiangiogenic effect. The examples here presented highlight the great promise of this type of strategies for the development of future therapeutics. Yes
- Published
- 2020