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Aim: To investigate the linkage of matrix metalloproteinase (MMP) gene polymorphisms with the pathogenesis of knee osteoarthritis (OA). Methods: This meta‐analysis study systematically retrieved relevant studies from PubMed, Embase, the Cochrane Central, Wanfang Data, CNKI, and SinoMed up to November 2020. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the association between MMP gene polymorphisms and OA. Results: A total of nine case–control studies comprising 1719 knee OA patients and 1904 controls were included in this meta‐analysis. The results revealed that MMP‐1‐1607 (rs1799750) 1G/2G polymorphism was not significantly associated with knee OA risk in four genetic models (OR (95% CI): allele model: 0.89 (0.57, 1.40), p =.615); dominant mode: 0.82 (0.47, 1.44), p =.486; recessive model: 0.88 (0.49, 1.57), p =.659; homozygote model: 0.79 (0.34, 1.82), p =.576. The association was significant for dominant model of MMP‐3 C/T: 1.54 (1.10–2.15), p =.013, especially in Asian ethnicity (1.63 (1.11, 2.39), p =.013). Variants of MMP‐13 C/T polymorphism were associated with increased risk of knee OA development based on dominant model: 1.56 (1.19, 2.06), p =.001 and homozygote model: 2.12 (1.44, 3.13), p <.001, and there were significant associations between MMP‐13 C/T polymorphism and knee OA risk in Asian ethnicity under different genetic models (all p >.05). Conclusions: Present evidence suggested that the gene polymorphisms of MMP‐1‐1607 1G/2G may not be associated with the risk of OA. But, the dominant model of MMP‐3 and MMP‐13 polymorphisms in Asian ethnicity was significantly correlated with knee OA. [ABSTRACT FROM AUTHOR]

• We have 15 publications with 5,740 cases and 9,931 controls were included in this meta-analysis. • We found that the T allele of the X -ray cross-complementing group 3 protein (XRCC3) Thr241Met polymorphism was significantly associated with an increased risk to gynecological malignancies (GM) in Asians but not in Caucasians. • Our findings indicate that the effect of the XRCC3 Thr241Met polymorphism on the risk of GM is ethnically different and this SNP has its obvious effect on the development of GM in Asians. • There was no meta-analysis about the association between XRCC3 Thr241Met polymorphism and risk of GM until now. Studies have investigated the relationship between the X -ray cross- complementing group 3 (XRCC3) Thr241Met polymorphism and the risk of gynecological malignancies (GM) with the contradictory conclusions. Here, a meta-analysis was performed to provide clear picture of the association between Thr241Met and GM risk. The Pubmed and Chinese National Knowledge Infrastructure (CNKI) databases were searched for published eligible studies. The pooled odds ratios (OR) with their corresponding 95% confidence interval (CI) was used to assessed the strength of association. Totally, 15 publications with 5,740 cases and 9,931 controls were included. In the overall analysis, the results of meta-analysis showed no significant association between the Thr241Met and the risk of GM. However, in the Asians subgroup, significant increased risks were found in the comparisons of TT/CT+TT vs. CC(TT vs. CC: OR=3.25, 95% CI=1.47–7.18; CT+TT vs. CC: OR=1.51, 95%CI=1.10–2.09) in Asians; additionally, stratified analysis by cancer type in Asians, significantly increased risks was found in cervical carcinoma (CT vs. CC: OR=1.50, 95%CI=1.04–2.14; TT vs. CC: OR=3.14, 95%CI=1.38–7.14; CT+TT vs. CC: OR=1.64, 95% CI=1.17–2.31). It suggests that the risk of GM might be significantly increased by the XRCC3 Thr241Met polymorphism according to ethnicity and cancer types. Further studies with larger sample size in different ethnic populations and different sites of GM are needed to verify the findings. [ABSTRACT FROM AUTHOR]

Background and aims: The association between glutathione-S-transferase P1 (GSTP1) Ile105Val polymorphism and oxaliplatin-induced neuropathy has been investigated in a number of published studies. However, most of these studies were based on small sample sizes and the results remained inconsistent. To assess the relationship between GSTP1 gene Ile105Val polymorphism and its susceptibility to oxaliplatin-induced neuropathy, a meta-analysis of previous studies was conducted. Methods: Two investigators independently searched studies published up to December 2012 from the databases of PubMed, EMBASE and The Cochrane Library. The pooled effect was calculated as odds ratio (OR) and corresponding 95 % confidence intervals (CIs) using fixed-effect or random-effect model. Results: Twelve prospective trials and two retrospective clinical trials involving 2,191 participants met the inclusion criteria. Combined analyses of these studies showed no significant associations between GSTP1 Ile105Val polymorphism and oxaliplatin-induced neuropathy, yielding OR of 1.08 (95 %CI 0.67-1.74, P = 0.754) in dominant model. Similar results were also obtained in recessive model (OR = 1.67, 95 %CI 0.56-4.93, P = 0.357) and allelic analysis (OR = 1.22, 95 %CI 0.67-2.24, P = 0.513). Since significant heterogeneity across studies, the pooled effects were calculated by random-effect model. No evidence of publication biases was identified in this meta-analysis. Conclusion: This meta-analysis did not support the hypothesis that GSTP1 Ile105Val polymorphism was related to the occurrence of neurotoxicity in oxaliplatin-treated patients. Given the limited number of studies and potential bias, large-scale and well-designed clinical trials should be needed to confirm these hypotheses. [ABSTRACT FROM AUTHOR]

Abstract: Introduction: Variants of PLA2G7 gene have been reported to be associated with coronary heart disease (CHD) since ten years ago, but the available data on this relationship are inconsistent. A meta-analysis was conducted to assess the effect of PLA2G7 gene on CHD. Materials and Methods: Association studies were identified from the databases of PubMed, EMbase, Chinese National Knowledge Infrastructure (CNKI) and Wanfang by two investigators and pooled effects (odds ratio (OR), together with 95% confidence interval (CI)) were calculated. Results: 14 association studies focusing on three polymorphisms (A379V, V279F and R92H) in PLA2G7 gene and risk of CHD were included in meta-analysis, covering a total of 8,280 cases and 5,656 controls. Concerning R92H, a significantly increased CHD risk was observed in recessive model, with an OR of 1.31(1.02, 1.68). Nevertheless, combined analyses of studies of the A379V and V279F variants showed no significant overall association with CHD, yielding ORs of 0.99(0.85, 1.15) and 1.09(0.88, 1.35) in allelic analysis, with strong evidence of heterogeneity. Similar results were also obtained in dominant and recessive models. Conclusions: The results indicate 92H allele had probably increased the risk of CHD, while the hypothesized effects of A379V and V279F polymorphisms on CHD cannot be confirmed in present data. However, given the limited number of studies and the potential biases, the influence of these polymorphisms on CHD risk needs further investigation. [ABSTRACT FROM AUTHOR]