4 results on '"Aleixandre‐Benavent, Rafael"'
Search Results
2. COVID-19 and smoking: a systematic review and meta-analysis of the evidence
- Author
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Jiménez-Ruiz, Carlos A., López-Padilla, Daniel E., Alonso-Arroyo, Adolfo, Aleixandre-Benavent, Rafael, Solano-Reina, Segismundo, and Granda-Orive, José Ignacio de
- Subjects
Meta-analysis ,Revisión sistemática ,Smoking ,Systematic review ,COVID-19 ,Odds ratio ,Metaanálisis ,Tabaquismo - Abstract
[ES] [Objetivo] el objetivo del estudio ha sido responder a las siguientes preguntas: ¿Se asocia el consumo de tabaco en pacientes con Covid-19 con una progresión negativa y desenlace adverso de la enfermedad? y, ¿se asocia el consumo de tabaco, actual y pasado, a una mayor posibilidad de desarrollar COVID-19? [Material y Método]: Se realizó una revisión sistemática (RS) y metaanálisis (MA) de trabajos publicados previamente. La estrategia de búsqueda incluyó todos los descriptores conocidos sobre Covid-19 y tabaco y se realizó en diferentes bases de datos. Se utilizaron modelos estadísticos adecuados para abordar el tamaño del efecto en un metaanálisis: modelo de efectos aleatorios y de efectos fijos. [Resultados] Fueron identificados 34 artículos en la RS de los cuáles fueron incluidos 19 en el MA. Ser fumador o ex fumador se mostró como un factor de riesgo para una peor progresión de la infección por Covid-19 (OR 1,96 IC 95%, 1,36 – 2,83) y una mayor probabilidad de presentar una condición más crítica de la infección (OR 1,79 IC 95%, 1,19 – 2,70). Como limitaciones del MA encontramos que la mayoría de los estudios analizados eran observacionales con un sesgo de publicación limitado y con dos estudios discrepantes con el resto, aunque tras retirarlos del MA se mantenía el tabaco como un factor de riesgo de peor evolución. [Conclusión]El tabaquismo actual y pasado produce una forma clínica más grave de la Covid-19 y lleva con mayor frecuencia a estos pacientes a ingresar en cuidados intensivos, sean intubados y mueran., [EN] [Objective] The aim of this study was to determine if tobacco use in patients with Covid-19 is associated with a negative disease course and adverse outcome, and if smoking, current and past, is associated with a greater possibility of developing COVID-19. [Material and Methods] A systematic review (SR) and meta-analysis (MA) of previously published works were performed. The search strategy included all known descriptors for Covid-19 and tobacco and was conducted in different databases. Appropriate statistical models were used to address the effect size in meta-analysis, namely random effects and fixed effects model. [Results] Thirty-four articles were identified in the SR of which 19 were included in the MA. Being a smoker or former smoker was shown to be a risk factor for worse progression of Covid-19 infection (OR 1.96, 95% CI, 1.36 - 2.83) and a greater probability of presenting a more critical condition (OR 1.79 95% CI, 1.19 - 2.70). As limitations of the MA, we found that most of the studies analyzed were observational with limited publication bias. Two studies that disagreed with the rest were included, although after withdrawing them from the MA, smoking was maintained as a risk factor for worse progress. [Conclusion] Current and past smoking produces a more serious clinical form of Covid-19 and more frequently leads to intensive care admission, intubation, and death.
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- 2020
3. The Global Research Collaboration of Network Meta-Analysis: A Social Network Analysis.
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Li, Lun, Catalá-López, Ferrán, Alonso-Arroyo, Adolfo, Tian, Jinhui, Aleixandre-Benavent, Rafael, Pieper, Dawid, Ge, Long, Yao, Liang, Wang, Quan, and Yang, Kehu
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MEDICAL research ,SOCIAL networks ,PHARMACEUTICAL industry ,HEALTH policy ,META-analysis - Abstract
Background and Objective: Research collaborations in biomedical research have evolved over time. No studies have addressed research collaboration in network meta-analysis (NMA). In this study, we used social network analysis methods to characterize global collaboration patterns of published NMAs over the past decades. Methods: PubMed, EMBASE, Web of Science and the Cochrane Library were searched (at 9
th July, 2015) to include systematic reviews incorporating NMA. Two reviewers independently selected studies and cross-checked the standardized data. Data was analyzed using Ucinet 6.0 and SPSS 17.0. NetDraw software was used to draw social networks. Results: 771 NMAs published in 336 journals from 3459 authors and 1258 institutions in 49 countries through the period 1997–2015 were included. More than three-quarters (n = 625; 81.06%) of the NMAs were published in the last 5-years. The BMJ (4.93%), Current Medical Research and Opinion (4.67%) and PLOS One (4.02%) were the journals that published the greatest number of NMAs. The UK and the USA (followed by Canada, China, the Netherlands, Italy and Germany) headed the absolute global productivity ranking in number of NMAs. The top 20 authors and institutions with the highest publication rates were identified. Overall, 43 clusters of authors (four major groups: one with 37 members, one with 12 members, one with 11 members and one with 10 members) and 21 clusters of institutions (two major groups: one with 62 members and one with 20 members) were identified. The most prolific authors were affiliated with academic institutions and private consulting firms. 181 consulting firms and pharmaceutical industries (14.39% of institutions) were involved in 199 NMAs (25.81% of total publications). Although there were increases in international and inter-institution collaborations, the research collaboration by authors, institutions and countries were still weak and most collaboration groups were small sizes. Conclusion: Scientific production on NMA is increasing worldwide with research leadership of Western countries (most notably, the UK, the USA and Canada). More authors, institutions and nations are becoming involved in research collaborations, but frequently with limited international collaborations. [ABSTRACT FROM AUTHOR]- Published
- 2016
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4. Prevalence and comorbidity of attention deficit hyperactivity disorder in Spain: study protocol for extending a systematic review with updated meta-analysis of observational studies.
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Catalá-López, Ferrán, Ridao, Manuel, Núñez-Beltrán, Amparo, Gènova-Maleras, Ricard, Alonso-Arroyo, Adolfo, Aleixandre-Benavent, Rafael, Catalá, Miguel A., and Tabarés-Seisdedos, Rafael
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ATTENTION-deficit hyperactivity disorder ,ADULTS ,META-analysis ,DISEASES ,SCIENCE - Abstract
Background: Attention deficit hyperactivity disorder (ADHD) is a childhood-onset disorder characterized by a persistent pattern of symptoms of developmentally inappropriate and impaired inattention and/or hyperactivity/impulsivity, with difficulties often continuing into adulthood. ADHD can come with other comorbid conditions. The aim of this study will be to quantify the prevalence and comorbidity of ADHD among children, adolescent, and adult population in Spain. Methods/design: We designed and registered a study protocol for an update and expansion of a systematic review and meta-analysis of pooled prevalence data. We will include cross-sectional observational studies reporting prevalence of ADHD in Spain and conducted in the general population, outpatient, and/or school settings. The primary outcome will be the prevalence of ADHD. Secondary outcomes will be the prevalence of any physical or mental comorbidity in association with ADHD. No limitations will be imposed on publication status, study conduct period, and language of dissemination. Comprehensive literature searches will be conducted in multiple electronic databases, including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO, IME – Spanish Medical Index, and IBECS – Spanish Bibliographic Index of Health Sciences. We will also search Google Scholar, dissertation databases, and conference abstracts. Two team members will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The methodological quality (or risk of bias) of individual studies will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-analysis. Prevalence estimates will be stratified according to gender, age, and geographical location. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g., methodological quality, sample size, diagnostic criteria). Discussion: This systematic review and meta-analysis of observational data will provide an updated synthesis of the prevalence and comorbidity of ADHD in Spain. This study will also examine factors that may explain potential variations in prevalence data. The findings of this study will be published in a peer-reviewed journal. Systematic review registration: PROSPERO CRD42018106082. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
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