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Purpose To evaluate the impact of postoperative posturing with or without face-down on the anatomical and functional outcomes of macular hole surgery. Methods A literature-based meta-analysis was conducted to identify studies relevant to posturing following macular hole surgery ( MHS). PubMed and Web of Science databases were used to retrieve articles up to 1 June 2015. The primary measures included MH closure and ideal vision acuity improvement. Pooled odds ratios ( ORs) and 95% confidence intervals ( CIs) were estimated in Review Manager. Results Four randomized control trials ( RCTs) comprising 251 cases were included in the final meta-analysis. No face-down posturing ( FDP) after MHS revealed lower anatomic success rate compared to face-down posturing ( OR = 0.33, 95% CI [0.13, 0.81], p = 0.02). For holes smaller than 400 μm in size, the subgroup meta-analysis indicated no significant effect of FDP on successful hole closure ( OR = 0.29, 95% CI [0.01, 7.34], p = 0.45). However, when holes were larger than 400 μm, it seemed less effective on MH closure following surgery in no FDP group ( OR = 0.23, 95% CI [0.07, 0.71]), and this was statistically significant (p = 0.01). Conclusions Our work found that no FDP was not inferior to its face-down counterpart for the success of MHS when macular holes were smaller than 400 μm in size. For macular holes larger than 400 μm, statistical analysis proved that FDP might be necessary. More well-conducted randomized control trials are needed to verify our findings. [ABSTRACT FROM AUTHOR]

As one of the vascular complications of type 2 diabetes mellitus, the incidence of diabetes retinopathy is greatly increasing worldwide. Both genetic and environmental factors are involved in the pathologies. A meta-analysis was conducted to assess the association between transcription factor 7-like 2 polymorphism (rs7903146) and type 2 diabetic retinopathy. Published literature from PubMed, Web of Science and China National Knowledge Infrastructure were retrieved. Pooled odds ratios with 95% confidence intervals were calculated to estimate the strength of the association. Eight studies including 6422 participants were included in the final meta-analysis. Our analysis provides substantial evidence that the rs7903146 variant is significantly associated with the risk of diabetic retinopathy in Caucasian populations while not in East Asian populations. The variant of rs7903146 appeared more likely to be a promising genetic biomarker of diabetic retinopathy in Caucasians. [ABSTRACT FROM AUTHOR]