17 results on '"Liao, Lin"'
Search Results
2. Rabson-Mendenhall Syndrome: Analysis of the Clinical Characteristics and Gene Mutations in 42 Patients.
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Gong, Wenfeng, Chen, Wenzhe, Dong, Jianjun, and Liao, Lin
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METABOLIC syndrome ,GROWTH disorders ,GLYCOSYLATED hemoglobin ,INSULIN receptors ,INSULIN resistance - Abstract
Aims Rabson-Mendenhall syndrome (RMS) is a rare autosomal, recessive disorder characterized by severe insulin resistance due to mutations in the insulin receptor (INSR) gene. This study aims to analyze the clinical features and gene mutations in RMS, which have not been extensively studied. Methods PubMed, Embase, the China National Knowledge Infrastructure, and Wanfang were searched for "Rabson-Mendenhall syndrome" or "Black acanthosis hirsutism insulin resistance syndrome." Results A total of 42 cases from 33 articles were included. The body mass index ranged from 18.50 to 20.00 kg/m
2 with an average of 16.00 kg/m2 . There were no overweight (25.00∼29.90 kg/m2 ) or obese (≥30.00 kg/m2 ) patients. Acanthosis was present in 29 cases (29/42, 69.05%); growth retardation in 25 cases (25/42, 59.52%); dental anomalies including absence of teeth, crowding, and malocclusion in 23 cases (23/42, 54.76%); and hirsutism in 17 cases (17/42, 40.48%). The average glycosylated hemoglobin was 9.35%, and the average fasting blood-glucose was 8.44 mmol/L; the mean fasting insulin was 349.96 μIU/mL, and the average fasting C-peptide was 6.00 ng/mL. Diabetes was reported in 25 cases (25/33, 75.76%) all of which were diagnosed before 23 years old. All 42 patients had recorded gene mutations, with 22 patients (22/42, 52.38%) having ≥ 2 mutations and 20 cases (20/42, 47.62%) having only 1 mutation. No statistical differences were found in clinical features and laboratory parameters between patients with different mutations. Conclusion The study indicates that RMS should be considered in young patients with hyperinsulinemia, hyperglycemia with low weight, acanthosis nigricans, growth retardation, dental anomalies, and hirsutism. [ABSTRACT FROM AUTHOR]- Published
- 2024
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3. Association between adipokines and thyroid carcinoma: a meta-analysis of case-control studies
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Zhao, Junyu, Wen, Jing, Wang, Shengnan, Yao, Jinming, Liao, Lin, and Dong, Jianjun
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- 2020
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4. Prognostic value of plasma von Willebrand factor levels in major adverse cardiovascular events: a systematic review and meta-analysis
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Fan, Mengge, Wang, Xia, Peng, Xun, Feng, Shuo, Zhao, Junyu, Liao, Lin, Zhang, Yong, Hou, Yinglong, and Liu, Ju
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- 2020
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5. Macular hole surgery recovery with and without face-down posturing: a meta-analysis of randomized controlled trials
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Ye, Ting, Yu, Ji-guo, Liao, Lin, Liu, Lan, Xia, Ting, and Yang, Lei-lei
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- 2019
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6. Associations between the polymorphisms of main components in PI3K/Akt pathway and risk of diabetic kidney disease: A meta‐analysis.
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Fu, Hang, Guo, Congcong, Zhang, Jing, Xu, Lusi, Jiang, Shan, Guo, Siyi, Sheng, Qiqi, Zhao, Junyu, and Liao, Lin
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PI3K/AKT pathway ,DISEASE risk factors ,DIABETIC nephropathies ,RANDOM effects model ,TYPE 2 diabetes ,SINGLE nucleotide polymorphisms - Abstract
Aims: Diabetic kidney disease (DKD) is a severe microvascular complication frequently associated with type 1 and type 2 diabetes mellitus. The objective of this work was to evaluate the relevance of PI3K/Akt pathway polymorphisms and DKD susceptibility by a meta‐analysis. Methods: Case–control studies related to the relationship between PI3K/Akt pathway polymorphisms and DKD risk were searched from Pubmed, Embase, Cochrane Library, SINOMED, CNKI, and Wanfang databases. Statistical analysis and heterogeneity test were conducted by Review Manager 5.4. Results: Totally, 52 eligible studies were enrolled, including seven single nucleotide polymorphisms (SNPs) for four genes in the PI3K/AKT pathway (GNB3: rs5443; eNOS: rs1799983, rs869109213, rs2070744; IL‐6: rs1800795, rs1800796; TNFα: rs1800629). The "M" allele of eNOS rs1799983 was related to the increased risk of DKD under random effects model, especially in Asian population (Overall:M vs. W: I2 = 75%, OR = 1.29, 95%CI 1.07–1.56; MM + WM vs. WW: I2 = 75%, OR = 1.50, 95%CI 1.21–1.86). The "M" allele of eNOS rs869109213 was implicated with higher prevalence of DKD under random effects model, especially in Asian population (Overall:M vs. W: I2 = 63%, OR = 1.43, 95%CI 1.22–1.68; MM + WM vs. WW: I2 = 50%, OR = 1.36, 95%CI 1.16–1.58; MM vs. WM + WW: I2 = 59%, OR = 2.20, 95%CI 1.41–3.43). The "M" allele of eNOS rs2070744 was implicated with higher prevalence of DKD under random effects model, especially in Indian population (Overall: M vs. W: I2 = 47%, OR = 1.35, 95%CI 1.15–1.59; MM + WM vs. WW: I2 = 45%, OR = 1.32, 95%CI 1.07–1.62; MM vs. WM + WW: I2 = 65%, OR = 2.29, 95%CI 1.39–3.77). The "M" allele of IL‐6 rs1800796 was predominately associated with higher DKD risks under random effects model, especially in Asian population (Overall: M versus W: I2 = 23%, OR = 1.49, 95%CI 1.21–1.84; MM + WM vs. WW: I2 = 1%, OR = 1.43, 95%CI 1.15–1.77; MM + WM vs. WW: I2 = 71%, OR = 2.77, 95%CI 1.09–7.06). Conclusions: This meta‐analysis indicated that polymorphisms in the PI3K/Akt pathway in eNOS rs1799983, rs869109213, rs2070744, and IL‐6 rs1800796 were related to the increased risk of DKD. [ABSTRACT FROM AUTHOR]
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- 2023
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7. The Cardiovascular Benefits and Infections Risk of SGLT2i versus Metformin in Type 2 Diabetes: A Systemic Review and Meta-Analysis.
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Xu, Chunmei, He, Liping, Zhang, Jing, Xu, Lusi, Dong, Jianjun, and Liao, Lin
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METFORMIN ,SODIUM-glucose cotransporters ,TYPE 2 diabetes ,SODIUM-glucose cotransporter 2 inhibitors ,GENITALIA infections ,HYPOGLYCEMIC agents ,URINARY tract infections - Abstract
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and metformin are both widely accepted anti-hyperglycemic agents. However, there is still no systematic review evaluating the cardiovascular benefits and risk of infections of SGLT2i versus metformin. To make that clear, we designed this study. Public databases, including the Cochrane library database, PubMed, and Embase were searched for randomized clinical trials (RCTs) fitting the inclusion criteria. Two reviewers extracted the data and appraised the study quality independently. Thirteen RCTs enrolling 4189 patients were eligible for this analysis. Our results showed that compared with metformin, SGLT2i increased the risk of genitourinary tract infections (p < 0.00001). Further subgroup analysis suggested that the occurrence of urinary tract infections (UTI) was not statistically significant (p = 0.18), but the incidence of reproductive tract infections (RTI) was significantly increased in patients in the SGLT2i group compared with that in the metformin group (p < 0.00001). In addition, SGLT2i markedly decreased the levels of cardiovascular risk factor, including body weight, blood pressure, and triglyceride level, and significantly increased the HDL-cholesterol level (p < 0.00001) in patients versus that of metformin. For type 2 diabetes patients with obesity, SGLT2i was associated with more significant reductions in weight and blood pressure compared to metformin without an increased risk of genitourinary infections, and the reduction in fasting plasma glucose was superior in the SGLT2i group; the decrease in HbA1c was similar in both groups. Additionally, no significant publication bias was seen. Based on these findings, SGLT2i provided the similar antihyperglycemic effects, additional cardiovascular benefits, and a potential RTI risk compared with that of metformin. Our results indicate that SGLT2i is a good choice for those patients with metformin intolerance or resistance. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Common variant (rs9939609) in the FTO gene is associated with metabolic syndrome
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Zhou, Donghao, Liu, Hongjun, Zhou, Ming’ai, Wang, Shengxiang, Zhang, Jingling, Liao, Lin, and He, Fang
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- 2012
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9. Xuan Fei Bai Du Fang for treating coronavirus disease 2019: A protocol for systematic review and meta-analysis
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Jinming Yao, Yuying Cui, Guoliang Shao, and Liao Lin
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medicine.medical_specialty ,Funnel plot ,MEDLINE ,Cochrane Library ,law.invention ,03 medical and health sciences ,coronavirus disease 2019 ,0302 clinical medicine ,Randomized controlled trial ,Meta-Analysis as Topic ,systematic review ,law ,Study Protocol Systematic Review ,medicine ,Humans ,030212 general & internal medicine ,protocol ,business.industry ,SARS-CoV-2 ,Xuan Fei Bai Du Fang ,General Medicine ,Publication bias ,Random effects model ,COVID-19 Drug Treatment ,meta-analysis ,Research Design ,030220 oncology & carcinogenesis ,Family medicine ,Meta-analysis ,Relative risk ,business ,Drugs, Chinese Herbal ,Systematic Reviews as Topic ,Research Article - Abstract
Background: Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease with a high fatality rate. Up to now, there are an estimated 26 million confirmed cases and 865,000 deaths around the world. But no effective way can control this disease. As the country that first discovered and treated the COVID-19, China has formed relatively mature prevention and treatment methods such as “3 prescriptions and 3 drugs.” Xuan Fei Bai Du Fang, as a member of “3 prescriptions and 3 drugs,” has very good clinical effects Methods: The PubMed, EMBASE, ClinicalTrials.gov, Cochrane Library, China National Knowledge Infrastructure, and Wanfang databases were searched for randomized controlled studies published to date. This study only screens clinical randomized controlled trials on QFBDF for COVID-19 to evaluate its efficacy and safety. Import all literatures that meet the requirements into Endnote X9 software. The information was finally cross-checked by 2 reviewers. Papers selected for review were assessed for risk of bias according to the criteria. Quality assessment on design of study, risk of bias, indirectness and imprecision were assessed using the GRADE framework. Where sufficient studies were available, publication bias was assessed visually using funnel plots. Relative risks for primary and secondary outcomes were calculated on an intent-to-treat basis and pooled using random effects meta-analysis. the continuous is expressed by mean difference or standard mean difference, eventually the data is synthesized using a fixed effect model or a random effect model depending on whether or not heterogeneity exists. The heterogeneity of studies will be evaluated by Q-test and I2 statistic with RevMan5.3. Results: The time from a positive diagnosis to a negative result of 2 consecutive nucleic acid tests (not on the same day), cure rate. The results of our research will be published in a peer-reviewed journal. Conclusion: The purpose of this systematic review is to provide new evidence for the effectiveness and safety of Xuan Fei Bai Du Fang in the treatment of COVID-19. PROSPERO registration number: CRD42020213950.
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- 2020
10. Plasma levels of von Willebrand factor in type 2 diabetes patients with and without cardiovascular diseases: A meta‐analysis
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Liao Lin, Ju Liu, Xun Peng, Xia Wang, Mengge Fan, and Junyu Zhao
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medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Gastroenterology ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Von Willebrand factor ,Risk Factors ,Diabetes mellitus ,Internal medicine ,von Willebrand Factor ,Internal Medicine ,medicine ,Humans ,biology ,business.industry ,nutritional and metabolic diseases ,Type 2 Diabetes Mellitus ,Plasma levels ,Prognosis ,medicine.disease ,Confidence interval ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,Meta-analysis ,biology.protein ,business ,Biomarkers - Abstract
Chronic vascular complications are the major causes of death and disability of type 2 diabetes mellitus (T2DM) patients. von Willebrand factor (vWF) is involved in pathogenesis of cardiovascular diseases (CVD). Previous studies showed elevated plasma levels of vWF in T2DM patients with CVD, but the association has not been validated. The aim of this meta-analysis was to compare plasma levels of vWF in T2DM patients with and without CVD. We performed a meta-analysis based on published case-control studies of vWF in T2DM patients with and without CVD indexed in PubMed and other databases updated to April 2018. After independently assessing methodological quality and extracting data, 9 eligible studies were obtained including 576 cases and 632 controls. The standard mean difference (SMD) and 95% confidence intervals (95% CI) were calculated using random-effects model. Meta-analysis showed that plasma level of vWF was significantly higher in T2DM patients with CVD than T2DM patients without CVD (SMD = 0.61; 95% CI, 0.32-0.90; P
- Published
- 2019
11. Recombinant Human Thyrotropin-Stimulated Radioiodine Therapy in Patients with Multinodular Goiters: A Meta-Analysis of Randomized Controlled Trials.
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Xu, Chunmei, Wang, Ping, Miao, Huikai, Xie, Tianyue, Zhou, Xiaojun, Zhang, Qian, Jiang, Shan, Zhang, Rui, Liao, Lin, and Dong, Jianjun
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FIXED effects model ,META-analysis ,RANDOMIZED controlled trials ,IODINE isotopes ,GOITER ,REDUCTION potential ,PUBLICATION bias - Abstract
A potential reduction of goiter volume (GV) of recombinant human thyrotropin (rhTSH) on multinodular goiters (MNG) was previously reported but controversial. Hence we conducted a meta-analysis to estimate the effect of rhTSH-stimulated radioiodine therapy in patients with MNG. PubMed, Cochrane, CNKI, VIP, and Wanfang databases were searched. Mean difference (MD) and odds ratios with 95% confidence intervals (95% CI) were derived by using an inverse variance random-effects model and fixed-effects model, respectively. Six studies (n=237) were involved in the analysis. For 12 months follow up, high dose (>0.1 mg) of rhTSH significantly reduced GV (MD=17.61; 95% CI=12.17 to 23.04; p<0.00001) compared with placebo. No effective pooled results of low dose of rhTSH (<0.1 mg) were applicable for only one study included. For 6 months follow up, the source of heterogeneity was determined by subgroup and sensitivity analysis. High dose group showed vast improvement in GV reduction (MD=16.62; 95% CI=1.34 to 31.90; p=0.03). The reduction of low dose group compared with placebo was inferior to high dose group. No available data were obtained to assess the influence of rhTSH after 36 months follow up for the only included study. Hypothyroidism incidence was higher for rhTSH group. No publication bias was seen. High dose of rhTSH treatment-stimulated radioactive
131 I therapy after 6 months and 12 months follow up had a better effect in reducing GV, but with higher incidence of hypothyroidism. Owing to the limited methodological quality, more clinical researches are warranted in the future. [ABSTRACT FROM AUTHOR]- Published
- 2020
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12. Effects and Safety of Sitagliptin in Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.
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Zhang, Yuhan, Cai, Tian, Zhao, Junyu, Guo, Congcong, Yao, Jinming, Gao, Peng, Dong, Jianjun, and Liao, Lin
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FATTY liver ,ASPARTATE aminotransferase ,ALANINE aminotransferase ,GAMMA-glutamyltransferase ,META-analysis ,SITAGLIPTIN ,LIVER enzymes - Abstract
Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease. However, the treatment is limited. The aim of this meta-analysis was to evaluate the effects and safety of sitagliptin, a selective inhibitor of dipeptidyl peptidase-4 (DPP-4I), in treating NAFLD. Studies were sourced from electronic databases including PubMed, CENTRAL (Cochrane Controlled Trials Register), Embase, Medline, Web of Science, Clinical Trials, and CNKI to identify all randomized controlled clinical trials (RCTs) and non-RCTs in adult patients with NAFLD. Key outcomes were changes in serum levels of liver enzymes and improvement in hepatic histology and fat content measured by imaging or liver biopsy. Stata14.0 and RevMan5.3 were used for the meta-analysis. Seven studies with 269 NAFLD patients were included. Compared to the control group, sitagliptin treatment improved serum gamma-glutamyl transpeptidase (GGT) levels in the RCT subgroup (SMD = 0.79, 95% CI: 0.01–1.58). However, there was no significant improvement in serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels following sitagliptin treatment. Four of the included studies performed liver imaging, but sitagliptin treatment did not result in a significant reduction in liver fat content. Only five participants developed sitagliptin-related gastrointestinal discomfort. Our study suggests that sitagliptin effects individuals with NAFLD by improving serum GGT. Although sitagliptin is safe and well tolerated in NAFLD patients, it exerts no beneficial effects on liver transaminase and liver fat content in these patients. [ABSTRACT FROM AUTHOR]
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- 2020
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13. Tripterygium Glycosides Combined with Leflunomide for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.
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Yang, Yi-Jing, Deng, Ying, Liao, Lin-Li, Peng, Jun, Peng, Qing-Hua, and Qin, Yu-Hui
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PHYTOTHERAPY ,AUTOANTIBODIES ,BLOOD sedimentation ,C-reactive protein ,COMBINATION drug therapy ,CONFIDENCE intervals ,GLYCOSIDES ,JOINTS (Anatomy) ,LEFLUNOMIDE ,META-analysis ,RHEUMATOID arthritis ,SYSTEMATIC reviews ,TREATMENT effectiveness ,DATA analysis software ,DESCRIPTIVE statistics ,EVALUATION - Abstract
Objective. To undertake an overview on the overall effects of Tripterygium glycosides (TG) combined with Leflunomide (LEF) for rheumatoid arthritis (RA). Methods. We searched electronic databases from database establishment time to December 1, 2019. The clinical trial data of TG combined with LEF (trial group) and control group in the treatment of RA were collected. The Cochrane system was used to evaluate the quality of the literature. RevMan 5.3 software was used to conduct a meta-analysis of the eligible studies. Results. A total of 12 randomized controlled trials (RCTs) involving 834 patients with RA were included in this study. The meta-analysis results showed that morning stiffness (mean difference (MD) = −0.29, 95% confidential interval (CI) (−0.45, −0.12), P = 0.0005), tender joint count (MD = −1.51, 95% CI (−2.20, −0.83), P = 0.0001), swollen joint count (MD = -1.24, 95% CI (−1.59, −0.88), P = 0.0001), erythrocyte sedimentation rate (MD = −7.26, 95% CI (−9.92, −4.61), P = 0.0001), C-reactive protein (MD = −4.04, 95% CI (−4.93, −3.14), P = 0.0001), and rheumatoid factor (MD = −50.88, 95% CI (−72.30, −29.45), P = 0.0001) in the trial groups were lower than those in the control groups. The total effective rate in the trial group was better than that in the control group (risk ratio (RR) = 1.20, 95% CI (1.13, 1.28), P = 0.00001). However, there was no significant difference of adverse events (RR = 0.83, 95% CI (0.61, 1.13), P = 0.23) while comparing the trial groups with the control groups. Conclusion. Our results were found to be superior but limited evidence on the effectiveness of TG combined with LEF in the treatment of RA is available. [ABSTRACT FROM AUTHOR]
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- 2020
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14. Statins and Thyroid Carcinoma: a Meta-Analysis.
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Zhao, Junyu, Xu, Chunmei, Yao, Jinming, Yu, Changzhen, Liao, Lin, and Dong, Jianjun
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STATINS (Cardiovascular agents) ,ANTINEOPLASTIC agents ,CELL lines ,CONFIDENCE intervals ,LOVASTATIN - Abstract
Background/Aims: Experimental studies have reported the antineoplastic effects of statins in thyroid carcinoma; however, observational studies suggested that statins might increase the risk of thyroid carcinoma. Therefore, this study evaluated the antineoplastic effects of statins in both in vitro studies and animal models, as well as the epidemiological evidence.Methods: Databases—PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries— were searched. A meta-analysis was performed with sufficiently homogeneous studies. Eighteen articles were involved.Results: In in vitro studies, statins showed a concentration-dependent inhibition of cell line growth (weighted mean difference –34.68, 95% confidence interval –36.53 to –32.83). A significant efficacy of statin-induced apoptosis was observed (weighted mean difference [95% confidence interval]: 24 h, 57.50 [55.98–59.03]; 48 h, 23.43 [22.19–24.66]; 72 h, 51.29 [47.52–55.07]). Early apoptosis was increased in a dose- and time-dependent manner. In in vivo antitumor studies, lovastatin inhibited tumor growth, as shown by a reduction in tumor volume. However, two clinical studies showed discordant results from the experimental studies.Conclusion: Experimental studies revealed the antineoplastic efficacy of statins but statins were associated with thyroid carcinoma in clinical studies. This discrepancy may be due to the different concentrations of statins used and the effects of hyperlipidemia interventions, and thus further study is required. [ABSTRACT FROM AUTHOR]- Published
- 2018
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15. Physical exercise improves strength, balance, mobility, and endurance in people with cognitive impairment and dementia: a systematic review.
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Lam, Freddy MH, Huang, Mei-Zhen, Liao, Lin-Rong, Chung, Raymond CK, Kwok, Timothy CY, and Pang, Marco YC
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AEROBIC exercises ,CINAHL database ,COGNITION disorders ,CONFIDENCE intervals ,DEMENTIA ,POSTURAL balance ,EXERCISE physiology ,EXERCISE therapy ,EXPERIMENTAL design ,MEDICAL databases ,INFORMATION storage & retrieval systems ,PSYCHOLOGY information storage & retrieval systems ,LIFE skills ,RESEARCH methodology ,MEDLINE ,META-analysis ,PSYCHOLOGY of movement ,MUSCLE strength ,ONLINE information services ,PHYSICAL fitness ,PROBABILITY theory ,QUALITY of life ,REGRESSION analysis ,RESEARCH funding ,STATISTICAL hypothesis testing ,STRETCH (Physiology) ,THERAPEUTICS ,WALKING ,SYSTEMATIC reviews ,EVIDENCE-based medicine ,ACTIVITIES of daily living ,EFFECT sizes (Statistics) ,BODY movement ,BODY mass index ,RANDOMIZED controlled trials ,FUNCTIONAL training ,PUBLICATION bias ,DATA analysis software ,RESISTANCE training ,ODDS ratio ,EVALUATION - Abstract
Question Does physical exercise training improve physical function and quality of life in people with cognitive impairment and dementia? Which training protocols improve physical function and quality of life? How do cognitive impairment and other patient characteristics influence the outcomes of exercise training? Design Systematic review with meta-analysis of randomised trials. Participants People with mild cognitive impairment or dementia as the primary diagnosis. Intervention Physical exercise. Outcome measures Strength, flexibility, gait, balance, mobility, walking endurance, dual-task ability, activities of daily living, quality of life, and falls. Results Forty-three clinical trials (n = 3988) were included. According to the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) system, the meta-analyses revealed strong evidence in support of using supervised exercise training to improve the results of 30-second sit-to-stand test (MD 2.1 repetitions, 95% CI 0.3 to 3.9), step length (MD 5 cm, 95% CI 2 to 8), Berg Balance Scale (MD 3.6 points, 95% CI 0.3 to 7.0), functional reach (3.9 cm, 95% CI 2.2 to 5.5), Timed Up and Go test (–1 second, 95% CI –2 to 0), walking speed (0.13 m/s, 95% CI 0.03 to 0.24), and 6-minute walk test (50 m, 95% CI 18 to 81) in individuals with mild cognitive impairment or dementia. Weak evidence supported the use of exercise in improving flexibility and Barthel Index performance. Weak evidence suggested that non-specific exercise did not improve dual-tasking ability or activity level. Strong evidence indicated that exercise did not improve quality of life in this population. The effect of exercise on falls remained inconclusive. Poorer physical function was a determinant of better response to exercise training, but cognitive performance did not have an impact. Conclusion People with various levels of cognitive impairment can benefit from supervised multi-modal exercise for about 60 minutes a day, 2 to 3 days a week to improve physical function. [Lam FMH , Huang MZ, Liao LR, Chung RCK, Kwok TCY, Pang MYC (2018) Physical exercise improves strength, balance, mobility, and endurance in people with cognitive impairment and dementia: a systematic review. Journal of Physiotherapy 64: 4–15] [ABSTRACT FROM AUTHOR]
- Published
- 2018
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16. New agent to treat advanced or metastasized thyroid cancer, its efficacy, safety, and mechanism.
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Zhu, Huan‐gao, Zhao, Jun‐yu, Zhang, Rui, Liao, Lin, and Dong, Jian‐jun
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ACADEMIC medical centers ,CANCER cells ,DATABASES ,MEDICAL information storage & retrieval systems ,MEDLINE ,META-analysis ,METASTASIS ,ONLINE information services ,RESEARCH funding ,SAFETY ,SURVIVAL ,THYROID gland tumors ,SYSTEMATIC reviews ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,PHARMACODYNAMICS ,PROTEIN kinase inhibitors ,THERAPEUTICS - Abstract
Background Vandetanib is the first US Food and Drug Administration approved agent to treat advanced or metastasized thyroid cancer. To gain a better understanding of the drug, we conducted a systematic review of its efficacy and safety in patients with thyroid cancers. Methods Trial data was retrieved from Pubmed, EMBASE, Medline, China National Knowledge Infrastructure, and the Cochrane database without restrictions on language. A systematic review of the literature was performed to assess median progression-free survival ( PFS) and adverse events associated with vandetanib therapy for advanced or metastasized thyroid cancers. Results Vandetanib statistically prolonged PFS in comparison with the placebo (30.5 vs. 19.3 months, hazard ratio 0.46), It even prolonged PFS in surgically unresectable or metastatic differentiated thyroid cancer cases compared with the placebo (11.1 vs. 5.9 months, hazard ratio 0.63). Rash, diarrhea, neutropenia, and hypertension were the most frequent side effects. Conclusion Vandetanib can significantly improve PFS. Though it has some side effects, it is still a promising agent in the treatment of advanced or metastasized thyroid cancer, especially in those with metastasized or advanced medullary thyroid carcinoma. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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17. The effects of whole body vibration therapy on bone mineral density and leg muscle strength in older adults: a systematic review and meta-analysis.
- Author
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Lau, Ricky WK, Liao, Lin-Rong, Yu, Felix, Teo, Tilda, Chung, Raymond CK, and Pang, Marco YC
- Subjects
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ANALYSIS of variance , *CINAHL database , *INFORMATION storage & retrieval systems , *MEDICAL databases , *MEDICAL information storage & retrieval systems , *LEG , *MEDLINE , *META-analysis , *MUSCLE strength , *HEALTH outcome assessment , *PHYSICAL therapy , *RESEARCH funding , *VIBRATION (Mechanics) , *SYSTEMATIC reviews , *BONE density , *TREATMENT effectiveness , *DATA analysis software - Abstract
Objective: A systematic review and meta-analysis of randomized controlled trials was undertaken to determine whether whole body vibration improves bone mineral density and leg muscle strength in older adults.Data sources: Sources included MEDLINE, CINAHL, EMBASE, PEDro, PubMed, Science Citation Index and the reference list of each eligible article.Review methods: Article search and selection was performed independently by two researchers. The methodological quality of each selected article was rated by the PEDro scale.Results: Thirteen randomized trials (18 articles) totalling 896 subjects fulfilled the selection criteria. Four were considered to have good or excellent methodological quality and the rest were rated as fair. Meta-analyses revealed that whole body vibration has no significant effect on hip or lumbar spine bone mineral density in older women when compared with no intervention or active exercise (P > 0.05). Whole body vibration, however, had a significant treatment effect on knee extension dynamic strength (standardized mean difference = 0.63, P = 0.006), leg extension isometric strength (standardized mean difference = 0.57, P = 0.003), and functional measures of leg muscle strength such as jumping height (standardized mean difference = 0.51, P = 0.010) and performance in sit-to-stand (standardized mean difference = 0.72, P < 0.001) among older adults compared with no intervention.Conclusion: Whole body vibration is beneficial for enhancing leg muscle strength among older adults. However, the review suggests that whole body vibration has no overall treatment effect on bone mineral density in older women. No randomized trial has examined the effects of whole body vibration on bone mineral density in older men. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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