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A new xanthone derivative, 3,5,8-trihydroxy-2,2-dimethyl-3,4,4-trihydro-2 H,6 H-pyrano[3,2- b]-xanthen-6one ( 1), together with three known compounds, 5,8-dihydroxy-2,2-dimethyl-2 H,6 H-pyrano[3,2- b]xanthen6-one ( 2), cyclo-( N- O-methyl-L-Trp-L-Ile-D-Pip-L-2-amino-8-oxo-decanoyl) ( 3), and cyclo-(Phe-Tyr) ( 4), was isolated from the mangrove endophytic fungus No. ZSU-H16 obtained from the South China Sea coast. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. Compound 1 exhibited cytotoxicity against KB and KBV 200 cells with IC50 values greater than 50 μg/mL, respectively. [ABSTRACT FROM AUTHOR]

A new naphtho- γ-pyrone, 5-hydroxy-6,8-dimethoxy-2-benzyl-4H-naphtho[2,3-b]-pyran-4-one ( 1), together with three known compounds 5,7-dihydroxy-2-methylbenzopyran-4-one ( 2), 3,5-dihydroxy-2,7dimethylbenzopyran-4-one ( 3) and cyclo(Tyr-Tyr) ( 4) were isolated from the mangrove endophytic fungus Phomopsis sp. ZSU-H26 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. Primary bioassays showed that 1 exhibited cytotoxicity against HEp-2 and HepG2 cells with IC50 values of 10 and 8 μg/mL, respectively. [ABSTRACT FROM AUTHOR]

A new polyketide, 2-(7′-hydroxyoxooctyl)-3-hydroxy-5-methoxybenzeneacetic acid ethyl ester ( 1), together with three known compounds dothiorelone A ( 2), B ( 3), and C ( 4) were isolated from the mangrove endophytic fungus Phomopsis sp. ZSU-H76 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. Primary bioassays showed that 1 exhibited cytotoxicity against HEp-2 and HepG2 cells with IC50 values of 25 and 30 μg/mL, respectively. [ABSTRACT FROM AUTHOR]

A new griseofulvin derivative, 7-chloro-2',5,6-trimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2) cyclohexene)3,4'-dione (1), together with the known 2-acetyl-7-methoxybenzofuran (2), was isolated from the marine-derived mangrove endophytic fungus Sporothrix sp. (No. 4335). The structure of new compound 1 was elucidated by analysis of spectroscopic data. [ABSTRACT FROM AUTHOR]