1. Coordination of Distal Carboxylate Anion Alters Metal Ion Specific Binding in Imidazo[1,2-a]pyridine Congeners.
- Author
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Divya, Dhakshinamurthy, Mala, Ramanjaneyulu, Nandhagopal, Manivannan, Narayanasamy, Mathivanan, and Thennarasu, Sathiah
- Subjects
IMIDAZOPYRIDINES ,METAL ions ,CHEMORECEPTORS ,TRANSITION metal ions ,ANIONS ,GROUNDWATER ,METAL detectors - Abstract
Imidazo[1,2-a]pyridine derivatives have excellent potential for chelation with transition metal ions. Two new imidazo[1,2-a]pyridine-8-carboxylates were synthesized and characterized by
1 H NMR,13 C NMR, HRMS, and single crystal-XRD techniques. Methyl carboxylate (probe 1) turns on fluorescence upon coordination with Zn2+ , while sodium carboxylate (probe 2) turns off its fluorescence upon coordination with Co2+ or Cu2+ ions present in aqueous acetonitrile medium.13 C NMR study revealed that the change in metal ion specific binding was due to the involvement of carboxylate anion in complex formation with Co2+ or Cu2+ ions. The carboxylate anion at 8-position also enhanced the sensitivity of detection of probe 2 by an order of magnitude (detection limits: 3.804 × 10–7 M, probe 1/Zn2+ ; 0.420 × 10–7 M, probe 2/Co2+ and 0.304 × 10–7 M, probe 2/Cu2+ ). The detection limits of probes 1 and 2 comply well with the World Health Organization (WHO) and US Environmental Protection Agency (US-EPA) guidelines for detection of heavy metal ions present in drinking water and ground water. Both the probes form a 1:1 complex with Zn2+ , Co2+ or Cu2+ , and the stoichiometry was verified by Job plot and ESI-mass analysis. The sensing mechanism is explained using13 C NMR experiments, ESI-mass analytical data and theoretical DFT calculations. The suitability of probes 1 and 2 for on-site detection and quantitative determination of Zn2+ , Co2+ and Cu2+ ions present in biological, environmental and industrial samples is demonstrated. In addition, both 1 and 2 are used for detection of intracellular contamination of Zn2+ , Co2+ or Cu2+ ions in onion epidermal cells. [ABSTRACT FROM AUTHOR]- Published
- 2023
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