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As an alternative to chemotherapy, emerging gas therapy is considered a "green" treatment due to its minimal side effects. However, even typical gas molecules like nitric oxide (NO) face challenges such as a very short half-life (1.5-6 min), poor targeting, and limited therapeutic effects. This study employs a one-pot method to simultaneously encapsulate the NO donor L-arginine (L-Arg) and the H 2 O 2 precursor Vitamin K3 (VK3) into the pores of zeolitic imidazolate framework-8 (ZIF-8), achieving their co-delivery to tumor sites to address these issues. Furthermore, ZIF-8 is functionalized with hyaluronic acid (HA) to impart active targeting properties to tumor tissues. In the acidic tumor microenvironment, pH-sensitive ZIF-8 degrades, releasing VK3 and L-Arg. Under the action of the NAD(P)H quinone oxidoreductase-1 (NQO1) enzyme, VK3 generates H 2 O 2 , increasing oxidative stress levels in the tumor microenvironment, and reacts with L-Arg to produce NO, thereby achieving tumor oxidative stress-based gas therapy. Both in vitro and in vivo experiments showed good tumor treatment effects, with a tumor inhibition rate of up to 90.5 % and minimal impact on normal tissues and organs. This approach demonstrates efficient loading, controlled release, and significant anti-tumor performance, offering new insights into gas and reactive oxygen species (ROS) synergistic therapy., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Antibiotics are crucial for treating and preventing bacterial infections. However, the widespread use of antibiotics has led to serious antibiotic resistance issues. To address the growing threat of antibiotic-resistant bacterial infections, we designed and synthesized an antibacterial composite material, CCM@ZIF-8@PDA, through a one-pot method and surface modification strategy. This material combines the antibacterial properties of the natural product curcumin, the advantages of ZIF-8, and the photothermal conversion capability of PDA. It exhibits three antibacterial mechanisms against S. aureus : chemical antibacterial, ionic antibacterial, and photothermal antibacterial effects. At a low concentration of 100 ppm, CCM@ZIF-8@PDA achieves a 100% antibacterial rate. This multi-modal antibacterial strategy provides insights for developing new antibacterial materials to combat antibiotic resistance.

Mass transfer of bulky molecules, e.g ., bioenzymes, particularly for cross-scale multibiomolecules, imposes serious challenges for microporous metal-organic frameworks (MOFs). Here, we create a hierarchically porous MOF heterostructure featuring highly region-ordered micro-, meso-, and macro-pores by growing a microporous ZIF-8 shell onto a hollow Prussian blue core through an epitaxial growth strategy. This allows for localized loading of large bioenzyme glucose oxidase (GOx) and small drug 5-fluorouracil (5-FU) within specific pores simultaneously and triggers unique guest-carrier cooperative anticancer capabilities. The stable ZIF-8 outer layer effectively blocks the core pores, preventing the undesired leakage of GOx into normal tissues. The acidity-induced ZIF-8 degradation gradually releases Zn 2+ and loaded 5-FU for chemotherapy under acidic tumor microenvironments. With the loss of the shielding effect of the ZIF-8 coating, the released GOx depletes intratumoral glucose (Glu) for starvation therapy. Notably, an accelerated cascade reaction occurs between ZIF-8 decomposition and GOx release, facilitated by the modulator factor of Glu. This culminates in the realization of synergistic cancer therapy, as comprehensively demonstrated by in vitro and in vivo experiments, as well as transcriptome sequencing analyses. Our work not only introduces a hierarchically porous MOF heterostructure with highly region-ordered pores but also provides a perspective for guest-carrier cooperative anticancer therapy.

Chemodynamic therapy (CDT) relying on Fenton reaction has emerged as a promising strategy for tumor treatment. However, its clinical efficacy is hindered by the inadequate reactive oxygen species (ROS) and the potential cytotoxicity towards normal cells. To address these challenges, we have successfully developed a multistage augmented cancer therapy system based on bimetallic metal-organic framework (BMOF) that amplifies ROS and facilitates tumor-specific therapeutic effects. By employing a simple one-pot self-assembly approach, we synthesized SVK3@ZnCo-ZIF in which sulfonated vitamin K3 (SVK3) was encapsulated within ZnCo-ZIF BMOF. The results revealed that the incorporation of Zn atoms significantly diluted the Fenton activity of Co atoms towards normal cells. Notably, SVK3@ZnCo-ZIF underwent pH-controlled decomposition triggered by the tumor microenvironment (TME), thus releasing SVK3, Co 2+ and Zn 2+ . Specifically, the H 2 O 2 levels in tumors was effectively elevated by the interaction of SVK3 with NAD(P)H quinone oxidoreductase-1 (NQO-1). It thus enhanced the Fenton activity of Co 2+ . Moreover, the release of Zn 2+ ions can induce cellular dysfunction and mitochondrial damage, thereby promoting the generation of ROS and subsequent cell death. The synergistic combination of CDT, SVK3 chemotherapy, and Zn 2+ -interfered therapy greatly facilitated apoptosis of tumor cells. Collectively, our investigations demonstrate the efficacy of such system in selectively inducing toxicity in cancer cells while minimizing detrimental effects on normal cells., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)

Cancer is still one of the most life-threatening diseases in the world. Among the various cancer therapeutic strategies, photothermal therapy (PTT) has attracted considerable attention due to its high treatment efficacy, low invasive burden, and minor side effects. Microporous metal-organic frameworks (MOFs) are potential materials for photothermal tumor treatment thanks to their high surface areas, suitable pore geometry, and easy functionalization. Through designating organic linkers, encapsulating PTT agents and fabricating MOF hybrids, MOF-based treatment platforms have great potential in PTT. In this review, we mainly summarize the recent advances of MOFs in photothermal combined cancer therapy. The present challenges and possible future prospects in this field are also explored.

Chemotherapy is still an important and effective clinical treatment for cancer. However, individual drugs hardly achieve precise controlled release and targeted therapy, thus resulting in unavoidable side effects. Fortunately, the emergence of drug carriers is expected to solve the above problems. In this work, the MOF-on-MOF strategy was adopted to encapsulate DOX into double-layer NH 2 -MIL-88B to fabricate a core-shell-structured DOX@NH 2 -MIL-88B-On-NH 2 -MIL-88B (DMM) and then realize the pH and GSH dual-responsive controlled DOX release. Because of the core-shell structure, the drug-loading capacity of DMM reached 14.4 wt %, which was nearly twice that of DOX@NH 2 -MIL-88B (DM), and the controlled release performance of DMM was also improved at the same time, greatly improving the kinetics equilibrium time of DOX from 2 h (DM) to 16 h (DMM) at pH 5.0. Moreover, we found that DMM also possessed peroxidase-like catalytic activity under acidic conditions, which could catalyze H 2 O 2 to produce • OH, exhibiting the potential chemodynamical treatment of cancer. Cell experiments showed that DMM had a significant inhibitory effect against 4T1 cancer cells, and the survival rate of 4T1 cells was less than 20% at 100 ppm.

Asthma is a common chronic disorder, and the decreased hydrogen sulfide (H 2 S) production in the lung has been considered as an early detection biomarker for asthma. However, the detection of H 2 S in biological systems remains a challenge; because it requires the designed sensors to have the following features: nanoscale size, good biocompatibility, real-time detection, high selectivity/sensitivity, and good water stability. Here, we propose the potential of using nanoscale fluorescent metal-organic framework (MOF) composites Eu 3+ /Ag + @UiO-66-(COOH) 2 (hereafter denoted as EAUC) as a logic platform for tentative diagnosis of asthma by detecting the biomarker H 2 S. This INHIBIT logic gate based on Eu 3+ @UiO-66-(COOH) 2 (EUC) can be produced by choosing Ag + and H 2 S as inputs and by monitoring the fluorescent signal (I 615 ) as an output. Our fluorescent studies indicate that the EAUC exhibits excellent selectivity, extreme sensitivity (limit of detection: 23.53 μM), and real-time in situ detection of H 2 S. Further, MTT analysis in PC12 cells shows that the EAUC possesses low cytotoxicity and favourable biocompatibility that are suitable for the detection of biomarker H 2 S in vivo, as demonstrated by the successful detection of spiked H 2 S in the diluted serum samples. This work represents the possibility of using MOF-based logic platform for tentative diagnosis of asthma in clinical medicine., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Drug delivery carriers with a high drug loading capacity and biocompatibility, especially for controlled drug release, are urgently needed due to the side effects and frequently dose in the traditional therapeutic method. In our work, a Zr-based metal-organic framework named ZJU-801, which is isoreticular with NU-801, has been designed and further demonstrated as an excellent drug delivery system (DDS) with a high drug loading of 41.7 %. Such a high drug loading capacity may be ascribed to the appropriate match of the size and the large pore volume of this kind of Zr MOF material. Compared with DS@NU-801, this DDS has successfully achieved on-command heating-activated drug release, which was probably attributed to the bulkier ligand, the better stability, and the intense π-π interaction between ZJU-801 and diclofenac sodium (DS) demonstrated comprehensively by SEM, powder X-ray diffraction (PXRD), FTIR and 13 C solid-state NMR spectroscopy as well as computer simulations. It is worth noting that premature drug release was avoided effectively without any complicated post-modifications. The low cytotoxicity and good biocompatibility of our DDS were certificated by the in vitro favorable results from an MTT assay, a WST-1 assay, and confocal microscopy imaging., (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

In addition to drugs, natural compounds such as functional food factors have demonstrated great potential for cancer therapy due to their low cost, mild side effects, and common raw materials. However, their short half‐life period, easy decomposition, and lack of targeting severely limit their further development. Metal‐organic frameworks (MOFs) are a new type of porous crystalline materials that are created by combining metal clusters and organic linkers. MOFs have enormous applications, particularly in the biomedical field, due to their ability for pre‐functional design and post‐functional modification. In this mini‐review, we summarize recent research progress on combining MOFs with natural compounds for anti‐cancer performance, which will provide new insights for future research in the biomedical field. [ABSTRACT FROM AUTHOR]

Designing metal‐organic framework (MOF)‐based catalysts with superior oxygen evolution reaction (OER) activity and robust durability simultaneously is highly required yet very challenging due to the limited intrinsic activity and their elusive evolution under harsh OER conditions. Herein, a steady self‐reconstructed MOF heterojunction is constructed via redox electrochemistry and topology‐guided strategy. Thanks to the inhibiting effect from hydrogen bonds of Ni‐BDC‐1 (BDC=1,4‐benzenedicarboxylic acid), the obatained MOF heterojunction shows greatly improved OER activity with low overpotential of 225 mV at 10 mA cm−2, relative to the totally reconstructed Ni‐BDC‐3 (332 mV). Density function theory calculations reveal that the formed built‐in electric field in the MOF heterojunction remarkably optimizes the ad/desorption free energy of active Ni sites. Moreover, such MOF heterojunction shows superior durability attributed to the shielding effect of the surface‐evolved NiOOH coating. [ABSTRACT FROM AUTHOR]

Cancer is still one of the most life-threatening diseases in the world. Among the various cancer therapeutic strategies, photothermal therapy (PTT) has attracted considerable attention due to its high treatment efficacy, low invasive burden, and minor side effects. Microporous metal–organic frameworks (MOFs) are potential materials for photothermal tumor treatment thanks to their high surface areas, suitable pore geometry, and easy functionalization. Through designating organic linkers, encapsulating PTT agents and fabricating MOF hybrids, MOF-based treatment platforms have great potential in PTT. In this review, we mainly summarize the recent advances of MOFs in photothermal combined cancer therapy. The present challenges and possible future prospects in this field are also explored. [ABSTRACT FROM AUTHOR]

Separation of acetylene from carbon dioxide remains a daunting challenge because of their very similar molecular sizes and physical properties. We herein report the first example of using copper(I)‐alkynyl chemistry within an ultra‐microporous MOF (CuI@UiO‐66‐(COOH)2) to achieve ultrahigh C2H2/CO2 separation selectivity. The anchored CuI ions on the pore surfaces can specifically and strongly interact with C2H2 molecule through copper(I)‐alkynyl π‐complexation and thus rapidly adsorb large amount of C2H2 at low‐pressure region, while effectively reduce CO2 uptake due to the small pore sizes. This material thus exhibits the record high C2H2/CO2 selectivity of 185 at ambient conditions, significantly higher than the previous benchmark ZJU‐74a (36.5) and ATC‐Cu (53.6). Theoretical calculations reveal that the unique π‐complexation between CuI and C2H2 mainly contributes to the ultra‐strong C2H2 binding affinity and record selectivity. The exceptional separation performance was evidenced by breakthrough experiments for C2H2/CO2 gas mixtures. This work suggests a new perspective to functionalizing MOFs with copper(I)‐alkynyl chemistry for highly selective separation of C2H2 over CO2. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is becoming an important cancer treatment in recent years. However, at present, the therapeutic effect of PDT is limited due to insufficient penetration depth of light. In this study, a new photodynamic system (d‐Lu)PCN‐224 is constructed by porphyrin‐based metal‐organic framework (MOF) PCN‐224 and bioluminescent molecule d‐fluorescein (d‐Lu). The bioluminescence (BL) spectrum of the reaction overlaps with the absorption spectrum of PCN‐224, so it is speculated that bioluminescence resonance energy transfer (BRET) between the MOF and d‐Lu which indicates inner light can be gained and used for PDT. Confocal imaging analysis and cytotoxicity assays have demonstrated that (d‐Lu)PCN‐224 can produce singlet oxygen and decrease the cell viability of SKOV‐3. This system provides a possibility of PDT for deep‐level organization without an external light source. [ABSTRACT FROM AUTHOR]

Hypochlorite/hypochlorous acid has been commonly regarded as one of the most vital reactive oxygen species in various physiological and pathological processes. However, the highly efficient detection of OCl − still remains a challenging work. Here, we fabricated a fluorescent MOF-based OCl − probe (ZIF-90-BA) by post-functionally modifying ZIF-90 with the Schiff base group. ZIF-90-BA features water stability, porous structures and functional sites. This probe was successfully used for OCl − turn-on fluorescence sensing. The Schiff base group on the ZIF-90-BA could be oxidized by OCl − and the flexible alkyl chain would put off, resulting in the turn-on fluorescence behavior. ZIF-90-BA exhibited high selectivity over other potentially interfering species, and it showed high sensitivity (detection limit: 6.25 μM) and fast response (15 s). It is anticipated that ZIF-90-BA can be a promising material for OCl − fluorescence sensing. [ABSTRACT FROM AUTHOR]

AlN homoepitaxy is a promising way to obtain high-quality AlN and Al-rich AlGaN and thus deep ultraviolet devices. The defect evolution in homoepitaxial AlN grown by high-temperature metal–organic chemical vapor deposition on AlN/sapphire templates was studied here. The schematic defect evolution model was given and the driving force of the dislocation motion was analyzed. Experimental results revealed that the dislocation line deflection angles changed differently for different types of threading dislocation at the interface of the AlN/sapphire template and the epilayer. The interface stress was considered to be the driving force of dislocation motion. The driving force needed for the change of deflection angles followed the sequence of pure screw dislocation ＞ mixed dislocation ＞ pure edge dislocation. The defect density exhibited a strong relationship with the strain states, indicating that the control of interface stress was an effective way to control the quality of homoepitaxial AlN. These results can not only provide deeper understanding of the AlN homoepitaxy mechanism, but also offer a way to grow high-quality AlN. [ABSTRACT FROM AUTHOR]

Efficient separation of the small gas molecules especially the hydrocarbons is essential to social economy. The microporous metal-organic frameworks (MOFs) are taking precedence in this respect by virtue of their irreplaceable advantages. Herein, the new organic linker 5-(5-carboxypyridin-3-yl)isophthalic acid simplified as H 3 L-N has been excavated to construct successfully the novel Zn-based heterocycle metal-organic framework ZnL·(DMF) 1.5 ·(H 2 O) 6.0 ( ZJU-197 , ZJU = Zhejiang University, DMF = N,N-dimethylformamide). ZJU-197 has been structurally characterized and explored in details for gas separation. It is commendable that the activated ZJU-197a has exhibited excellent C 2 H 2 /C 2 H 4 , CO 2 /CH 4 and CO 2 /N 2 separations simultaneously with IAST selectivity of 137.8, 53.0 and 514.1 respectively at ambient conditions. [ABSTRACT FROM AUTHOR]

Drug delivery carriers with a high drug loading capacity and biocompatibility, especially for controlled drug release, are urgently needed due to the side effects and frequently dose in the traditional therapeutic method. In our work, a Zr-based metal-organic framework named ZJU-801, which is isoreticular with NU-801, has been designed and further demonstrated as an excellent drug delivery system (DDS) with a high drug loading of 41.7 %. Such a high drug loading capacity may be ascribed to the appropriate match of the size and the large pore volume of this kind of Zr MOF material. Compared with DS@NU-801, this DDS has successfully achieved on-command heating-activated drug release, which was probably attributed to the bulkier ligand, the better stability, and the intense π-π interaction between ZJU-801 and diclofenac sodium (DS) demonstrated comprehensively by SEM, powder X-ray diffraction (PXRD), FTIR and 13C solid-state NMR spectroscopy as well as computer simulations. It is worth noting that premature drug release was avoided effectively without any complicated post-modifications. The low cytotoxicity and good biocompatibility of our DDS were certificated by the in vitro favorable results from an MTT assay, a WST-1 assay, and confocal microscopy imaging. [ABSTRACT FROM AUTHOR]

The precise and real-time monitoring of localized pH changes is of great importance in many engineering and environmental fields, especially for monitoring small pH changes in biological environments and living cells. Metal–organic frameworks (MOFs) with their nanoscale processability show very promising applications in bioimaging and biomonitoring, but the fabrication of nanoscale MOFs is still a challenge. In this study, we synthesized a nanoscale mixed-lanthanide metal–organic framework by a microemulsion method. The morphology and size of the NMOF can be simply adjusted by the addition of different amounts of the CTAB surfactant. This NMOF exhibits significant pH-dependent luminescence emission, which can act as a self-referenced pH sensor based on two emissions of Tb3+ at 545 nm and Eu3+ at 618 nm in the pH range from 3.00 to 7.00. The MTT assay and optical microscopy assay demonstrate the low cytotoxicity and good biocompatibility of the nanosensor. [ABSTRACT FROM AUTHOR]

A highly stable amino-coordinated metal–organic framework ZJU-198 has been synthesized and structurally characterized, exhibiting high CO2 uptake of 105.8 cm3 cm−3 while blocking off N2 adsorption at 1.0 bar and 298 K, attributed to the unique pore window sizes. [ABSTRACT FROM AUTHOR]

Two zinc-based porous metal-organic frameworks, ZJU-64 and ZJU-64-CH3, sharing the same crystal structure, have been synthesized from zinc ions, the biomolecular linker adenine, and carboxylate-based ligands, resulting in 3D frameworks with 1D channels (approximately 1.6 nm×1.9 nm). The materials ZJU-64 and ZJU-64-CH3 exhibit low toxicity by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay, microscopy images, and cell-cycle analysis; this indicates their potential applications for human health care. The anticancer drug methotrexate (MTX) is successfully loaded into MOFs by a simple impregnation method and the drug payloads reach approximately 13.45 and 10.63 wt % for ZJU-64 and ZJU-64-CH3, respectively. The sustainable drug-release behavior of MTX from MTX-loaded ZJU-64 and ZJU-64-CH3 is detected for several days. The temperature-responsive deliveries of ZJU-64 and ZJU-64-CH3 reveal that hyperthermia can control the drug release and open up a new treatment which combines drug therapy and thermal therapy to kill more cancer cells with fewer side effects; this reveals the practical value of ZJU-64 and ZJU-64-CH3 as 'smart' drug carriers with more therapeutic efficacy. [ABSTRACT FROM AUTHOR]

The development of new materials for separating ethylene (C2H4) from ethane (C2H6) by adsorption is of great importance in the petrochemical industry, but remains very challenging owing to their close molecular sizes and physical properties. Using isoreticular chemistry in metal–organic frameworks (MOFs) enables the precise design and construction of target materials with suitable aperture sizes and functional sites for gas separations. Herein, it is described that fine‐tuning of pore size and π‐complexation simultaneously in microporous copper(I)‐chelated MOFs can remarkably boost the C2H4/C2H6 adsorption selectivity. The judicious choice of organic linkers with a different number of carboxyl groups in the UiO‐66 framework not only allows the fine tuning of the pore size but also immobilizes copper(I) ions onto the framework. The tailor‐made adsorbent, CuI@UiO‐66‐(COOH)2, thus possesses the optimal pore window size and chelated Cu(I) ions to form π‐complexation with C2H4 molecules. It can rapidly adsorb C2H4 driven by the strong π‐complexation interactions, while effectively reducing C2H6 uptake due to the selective size‐sieving. Therefore, this material exhibits an ultrahigh C2H4/C2H6 selectivity (80.8), outperforming most previously described benchmark materials. The exceptional separation performance of CuI@UiO‐66‐(COOH)2 is validated by breakthrough experiments for 50/50 v/v C2H4/C2H6 mixtures under ambient conditions. [ABSTRACT FROM AUTHOR]

Baicalein (BA) is a natural compound with broad-spectrum antibacterial effects, achieved by disrupting bacterial cell membranes or inhibiting enzyme activity. However, the antibacterial efficacy of berberine is limited, and long-term use may lead to the development of resistance. Here, we have successfully developed a novel antibacterial nanoplatform, BA&ICG@ZIF-8, through in situ self-assembly. BA&ICG@ZIF-8 demonstrates excellent photothermal conversion capability, and the synergistic antibacterial effect between BA and ZIF-8 significantly enhances the antibacterial ability of BA. Under the condition of additional near-infrared laser, the combined action of BA, indocyanine green (ICG), and ZIF-8 further enhances the antibacterial performance of BA&ICG@ZIF-8. This study provides insights for the rational design of antibacterial nanoplatforms based on the in situ self-assembly strategy and the improvement of antibacterial properties of natural products. [Display omitted] • A novel MOF-based antibacterial platform BA&ICG@ZIF-8 has been fabricated. • BA&ICG@ZIF-8 demonstrates enhanced synergistic antibacterial performance. • The antibacterial efficacy of BA has been improved [ABSTRACT FROM AUTHOR]

Photodynamic therapy(PDT) has become an important cancer treatment method in recent years and is widely used in skin cancers and melanoma treatments. At present, PDT faces one of the most important obstacles, that is, the therapeutic field is limited due to insufficient penetration depth of light. In this study, a novel photodynamic system based on metal-organic framework (MOF) with integrated inner light, Lu@CoTCPP(Pd), was designed and synthesized. The system has selectivity as it only works in H 2 O 2 abundant areas such as melanoma, colorectal and ovarian tumors. This research may greatly expand the cure range of photodynamic therapy (PDT) through the inner chemiluminescence resonance energy transfer (CRET) induced singlet oxygen production. Schematic illustration of inner light photodynamic system, where Lu@CoTCPP(Pd) use endogenous hydrogen peroxide to generate singlet oxygen to kill cancer cells. Image 1 • A photodynamic system with integrated inner light (Lu@CoTCPP(Pd)) was successfully established. • This system can differentiate cancerous sites and normal cells through H 2 O 2. • Co cluster in MOFs can catalyze the chemiluminescence of luminol- H 2 O 2. • The established system can effectively eliminate tumor cells. • Introduction. [ABSTRACT FROM AUTHOR]

The cover picture shows the new metal–organic frameworks (MOFs) ZJU‐64 and ZJU‐64‐CH3, which exhibit low totoxicity, high stability, and temperature‐controlled drug‐release behaviors. The findings provide a strategy to enhance the therapeutic efficacy of these MOFs because of their capacity for combining drug and thermal therapies. More details can be found in the Full Paper by Guodong Qian and co‐workers on page 804 in Issue 8, 2016 (DOI: 10.1002/cplu.201600142). [ABSTRACT FROM AUTHOR]

• ZJU-194a features the unique flexible-robust network. • ZJU-194a affords high adsorptive C 2 H 2 /C 2 H 4 selectivity. • The distinct host–guest affinity accounts for different gate open-close states. The removal of trace acetylene (C 2 H 2) from raw ethylene (C 2 H 4) stream is critical for production of polymer-grade chemicals. We herein report a perchlorate-coordinated metal–organic framework (ZJU-194) featuring flexible-robust network for efficient C 2 H 2 /C 2 H 4 separation. The distinct-different host–guest affinity accounts for two-step gate-opening adsorption of C 2 H 2 , but gate-close of C 2 H 4. It thus affords very high adsorptive selectivity (28.9) at ambient conditions, endowing ZJU-194 among one of the top-performing porous materials for C 2 H 2 /C 2 H 4 separation. [ABSTRACT FROM AUTHOR]

A novel metal-organic framework (MOF) fluorescent probe UiO-66-PSM is obtained by the copper-catalyzed azide-alkyne click (CuAAC) reaction of UiO-66-N 3 with phenylacetylene. The click-generated triazole unit can act as the metal binding site to coordinate with Hg 2+ , which exhibits the most pronounced fluorescence response (rapid response, excellent selectivity, and high sensitivity) over other metal ions. Moreover, it is capable of detecting Hg 2+ in environmental water samples without any structural disintegration of the framework, indicating its high potential in practical applications. [ABSTRACT FROM AUTHOR]

A porous metal-organic framework Zn-TBDA (TBDA = 4′-(1H-tetrazol-5-yl) -[1,1′-biphenyl]-3,5-dicarboxylic acid) with one-dimensional channels has been synthesized from zinc ions and bifunctional ligands. The negligible cytotoxicity of Zn-TBDA is confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium (MTT) assay and microscopy observation. The anticancer drug methotrexate (MTX) is loaded into Zn-TBDA successfully via in-situ encapsulation and the loading capability reaches about 12.59 wt% in resulting composite MTX-encapsulated Zn-TBDA. Under different physiological microenvironments, MTX-encapsulated Zn-TBDA exhibits sensitive pH and temperature dual-responsive release manners, revealing its practical value as a smart drug carrier with controlled release in certain site and improved therapeutic efficacy without any additional external fields. [ABSTRACT FROM AUTHOR]

A low cytotoxic porphyrin-based metal–organic framework (MOF) PCN-221, which exhibited high PC12 cell viability via 3-(4,5-dimethylthiazol-2-yl)−2,5-diphenyl tetrazolium (MTT) assay, was selected as an oral drug carrier. Methotrexate (MTX) was chosen as the model drug molecule which was absorbed into inner pores and channels of MOFs by diffusion. PCN-221 showed high drug loading and sustained release behavior under physiological environment without “burst effect”. The controlled pH-responsive release of drugs by PCN-221 revealed its promising application in oral drug delivery. [ABSTRACT FROM AUTHOR]

An organic linker H 2 FBDA (H 2 FBDA = (2E, 2′E)-3,3'-(2-fluoro-1,4-phenylene) diacrylic acid) with the electron-withdrawing fluoro-group, has been applied to construct a Zr-based metal-organic framework, the ZJU-800 (ZJU = Zhejiang University). ZJU-800 , derived from UiO-66 and isostructural with NU-801, is explored for high-pressure methane storage capacity of 10.0 mmol/g at 65 bar and room temperature, with good thermal and water stability. It is shown that the amount of methane uptake is 61.2% higher than that of UiO-66 at 35 bar. A microporous Zr-based metal-organic framework (MOF) with the electron-withdrawing fluoro-group and high porosity has been prepared. It exhibits a high-pressure methane storage capacity of 10 mmol/g at 65 bar and 298 K. Image 1 • A Zr-based MOF ZJU-800 with fluoro-functional group was synthesized and characterized. • ZJU-800 has two types of polyhedral cages and exhibits high porosity and stability. • ZJU-800 shows high CH 4 adsorption capacity of 10.0 mmol/g at 65 bar and 298 K. [ABSTRACT FROM AUTHOR]

• The zinc-adeninate MOF ZJU-64-NH 2 has been synthesized for the first time. • The Ca2+-responsive PA delivery make it a promising candidate as a carrier. • The biocompatibility of ZJU-64-NH 2 has been thoroughly demonstrated. An anionic zinc-adeninate MOF ZJU-64-NH 2 has been successfully fabricated by solvothermal method. The high crystallinity of ZJU-64-NH 2 was confirmed through powder X-ray diffraction (PXRD) analysis. The cationic model drug procainamide (PA) was efficiently encapsulated into ZJU-64-NH 2 through electrostatic interaction, and its loading capacity was determined to be 12.97 wt%. The drug delivery system PA@ZJU-64-NH 2 exhibited Ca2+-triggered drug release due to ion exchange, indicating promising potential for bone tumor therapy. The excellent biocompatibility of ZJU-64-NH 2 was demonstrated through MTT assay and confocal microscopy imaging. [ABSTRACT FROM AUTHOR]

Hydrogen sulfide (H 2 S) has been commonly viewed as a gas signaling molecule in various physiological and pathological processes. However, the highly efficient H 2 S detection still remains challenging. Herein, we designed a new robust nano metal-organic framework (MOF) UiO-66-CH=CH 2 as a fluorescent probe for rapid, sensitive and selective detection of biological H 2 S. UiO-66-CH=CH 2 was prepared by heating ZrCl 4 and 2-vinylterephthalic acid via a simple method. UiO-66-CH=CH 2 displayed fluorescence quenching to H 2 S and kept excellent selectivity in the presence of biological relevant analytes especially the cysteine and glutathione. This MOF-based probe also exhibited fast response (10 s) and high sensitivity with a detection limit of 6.46 μM which was within the concentration range of biological H 2 S in living system. Moreover, this constructed MOF featured water-stability, nanoscale (20–30 nm) and low toxicity, which made it a promising candidate for biological H 2 S sensing. [ABSTRACT FROM AUTHOR]