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Immune checkpoint blockade has become a paradigm-shifting treatment modality to combat cancer, while conventional administration of immune checkpoint inhibitors, such as anti-PD-L1 antibody (α-PD-L1), often shows unsatisfactory immune responses and lead to severe immune-related adverse effects (irAEs). Herein, we develop a PD-L1 aptamer-based spherical nucleic acids (SNAs), which consists of oxaliplatin (OXA) encapsulated in a metal-organic framework nanoparticle core and a dense shell of aptPD-L1 (denoted as M@O-A). Upon light irradiation, this nanosystem enables concurrent photodynamic therapy (PDT), chemotherapy, and enhanced immunotherapy in one shot to inhibit both primary colorectal tumors and untreated distant tumors in mice. Notably, M@O-A shows scarcely any systemic immunotoxicity in a clinical irAEs-mimic transgenic mouse model. Collectively, this study presents a novel strategy for priming robust photo-immunotherapy against cancer with enhanced safety., (© 2022 Wiley-VCH GmbH.)

Poly(3,4-ethylenedioxythiophene) (PEDOT) is introduced on the surface of a metal–organic framework material by solvothermal method to prepare nanorods (TE@Zn-MOFs) with both flame retardant and thermoelectric properties. Data from cone calorimeter and TG-IR show that TE@Zn-MOFs effectively improves the flame retardant and smoke suppression properties of epoxy-based coatings. At a high TE@Zn-MOFs content of 10 wt%, the coating oxygen index increased from 18.2% to 29.0%, the total smoke release decreased from 25.26 to 22.60 m2, and the V-0 level was achieved in vertical combustion classification. Moreover, PEDOT enables epoxy-based coatings to output a certain current value at different heating temperatures (50–200°C). This work demonstrates that MOFs with flexible and variable structures can serve as effective flame retardants for epoxy-based coatings and endow coatings with fire warning characteristics, providing a way to develop multifunctional coatings for different application scenarios.

A metal–organic framework (MOF) formed between Zn and p‐hydroxybenzoic acid (PHBA) is synthesized using a solvothermal method. These Zn‐PHBA nanorods, which are inexpensive and suitable for mass production, are added as a flame‐retardant into vinyl resin (430 LV, a material used in marine composites). Data from cone calorimetric test demonstrates that adding the Zn‐PHBA nanorods to 430 LV significantly improves flame retardation and smoke suppression. At a high Zn‐PHBA content of 10.0 wt%, the limiting oxygen index of 430 LV increases from 19.5% to 28.5%, and the material reaches the V‐0 rating in vertical burning tests (UL‐94). Moreover, the tensile and impact strengths of 430 LV containing 10 wt% Zn‐PHBA as flame‐retardant do not deteriorate and are even slightly improved. This work demonstrates that this MOF synthesized by a simple and efficient method may be used to produce nanocomposites with excellent flame retardation and mechanical properties, while keeping the material cost sufficiently low for marine applications. [ABSTRACT FROM AUTHOR]

Immune checkpoint blockade has become a paradigm‐shifting treatment modality to combat cancer, while conventional administration of immune checkpoint inhibitors, such as anti‐PD‐L1 antibody (α‐PD‐L1), often shows unsatisfactory immune responses and lead to severe immune‐related adverse effects (irAEs). Herein, we develop a PD‐L1 aptamer‐based spherical nucleic acids (SNAs), which consists of oxaliplatin (OXA) encapsulated in a metal–organic framework nanoparticle core and a dense shell of aptPD‐L1 (denoted as M@O‐A). Upon light irradiation, this nanosystem enables concurrent photodynamic therapy (PDT), chemotherapy, and enhanced immunotherapy in one shot to inhibit both primary colorectal tumors and untreated distant tumors in mice. Notably, M@O‐A shows scarcely any systemic immunotoxicity in a clinical irAEs‐mimic transgenic mouse model. Collectively, this study presents a novel strategy for priming robust photo‐immunotherapy against cancer with enhanced safety. [ABSTRACT FROM AUTHOR]

Metal–organic framework (MOF)-derived hybrids are promising electrode materials for electrochemical energy storage due to their high surface area, which provide plentiful redox sites and excellent electrical conductivity compared with fresh MOFs. Herein, different derivative strategies (oxidation, vulcanization, and phosphorization) were used to improve the energy storage performance of ZIF-67 metal–organic framework in the electrode of supercapacitor. The energy storage performance of the derived material is obviously improved compared with that of the untreated material through a series of analysis results, while the phosphating strategy has better modification ability than the oxidation and vulcanization strategy. Thanks to the good conductivity and suitable hole size of the phosphide, P-ZIF-67 shows the best charge storage ability, while the mass specific capacitance is 120.01 F g−1 under a current density of 1 A g−1. Besides, the fabricated P-ZIF-67//AC asymmetric device presented an energy density of 19.7 W h kg−1 at a power density of 500 W kg−1. This work provides experimental basis for the further application of ZIF-67 in supercapacitors. [ABSTRACT FROM AUTHOR]

A high-efficiency Ni-MOF-74/CdS/Co3O4 composite catalyst, the CdS co-boosting with Ni-MOF-74 and Co3O4, is successfully prepared. The maximum amount of hydrogen evolution reaches about 581 μmol for 5 h over the Ni-MOF-74/CdS/Co3O4 (10 wt% Co) photocatalyst under visible light irradiation, which is 16.2 times higher than that over pure CdS. The detailed physical and chemical inner mechanism of the Ni-MOF-74/CdS/Co3O4 composite catalyst is investigated by means of XRD, SEM, TEM, XPS, BET, UV-visible DRS etc. In the most valuable aspect, we investigate the photoelectron and hole transfer mechanism by photoluminescence spectroscopy, excited state electron decay, and photoelectrochemical experiments. The results show that the lower electron and hole pair recombination, larger electron transfer rate constant (KET = 0.2 × 109 s−1), larger electron injection efficiency (ηinj = 44.7%), smaller carrier charge resistance in the semiconductor film (Rfilm = 3523 Ω cm2), and smaller charge transfer and reaction resistance at the interface between the semiconductor and the electrolyte (Rct = 1.96 Ω cm2) together accelerate the charge separation and transfer, thereby enhancing photocatalytic performance. [ABSTRACT FROM AUTHOR]

A low-cost metal-organic framework suitable for high-efficiency production is synthesized by a solvothermal method using a transition element Zn and 4-hydroxybenzoic acid (HBA). These hollow Zn-HBA nanospheres are added to epoxy resin-based coating (E 51-LP 3) to form a flame-retardant and thermal insulation coating. Data obtained from cone calorimetric test demonstrates that the addition of Zn-HBA nanospheres effectively inhibits the combustion and smoke release of the coating. At Zn-HBA content of 50.0 vol%, the limiting oxygen index increases by 46% (from 21.5% to 31.5%) and UL 94 rating reaches V-0. Moreover, the thermal insulation performance of E 51-LP 3 containing 50 vol% Zn-HBA as flame-retardant is also significantly improved. This work demonstrates that these low-cost hollow Zn-HBA nanospheres, suitable for high-efficiency production, can be used as an additive to produce nanocoatings with both excellent flame-retardant and thermal insulation properties, while providing a solution for reducing the cost of multifunctional coatings. •A low-cost MOF (Zn-HBA nanospheres) for mass production was synthesized. • Zn HBA nanospheres can be used as efficient flame retardant for epoxy coatings. • Zn-HBA nanospheres improve thermal insulation performance of epoxy coatings. • This work may provide a solution for low-cost nano multifunctional coatings. [ABSTRACT FROM AUTHOR]

Upon light irradiation, the versatile M@O-A allows for robust photo-immunotherapy against cancer by combining photodynamic therapy, chemotherapy, and immunotherapy in one nanoplatform with reduced immunotoxicity. DNA Nanotechnology, Immunotherapy, Metal-Organic Frameworks, PD-L1 Aptamer, Spherical Nucleic Acids (SNAs) Keywords: DNA Nanotechnology; Immunotherapy; Metal-Organic Frameworks; PD-L1 Aptamer; Spherical Nucleic Acids (SNAs) EN DNA Nanotechnology Immunotherapy Metal-Organic Frameworks PD-L1 Aptamer Spherical Nucleic Acids (SNAs) 1 1 1 01/27/23 20230126 NES 230126 B PD-L1 aptamer-based spherical nucleic acids b (SNAs) were designed that consist of oxaliplatin (OXA) encapsulated in a metal-organic framework (MOF) nanoparticle core and a dense shell of PD-L1 aptamer (denoted as M@O-A), as reported by Zhengyu Jin, Jie Tian, Yang Du, and co-workers in their Research Article (e202214750). [Extracted from the article]

DNA Nanotechnology, Immunotherapy, Metal-Organic Frameworks, PD-L1 Aptamer, Spherical Nucleic Acids (SNAs) Back Cover: PD-L1 Aptamer-Functionalized Metal-Organic Framework Nanoparticles for Robust Photo-Immunotherapy against Cancer with Enhanced Safety (Angew. Keywords: DNA Nanotechnology; Immunotherapy; Metal-Organic Frameworks; PD-L1 Aptamer; Spherical Nucleic Acids (SNAs) EN DNA Nanotechnology Immunotherapy Metal-Organic Frameworks PD-L1 Aptamer Spherical Nucleic Acids (SNAs) 1 1 1 01/27/23 20230126 NES 230126 B PD-L1 aptamer-based spherical nucleic acids b (SNAs) were designed that consist of oxaliplatin (OXA) encapsulated in a metal-organic framework (MOF) nanoparticle core and a dense shell of PD-L1 aptamer (denoted as M@O-A), as reported by Zhengyu Jin, Jie Tian, Yang Du, and co-workers in their Research Article (e202214750). [Extracted from the article]

MOFs (ZIF-67) and g-C 3 N 4 catalyst-modified MoS 2 nanoparticles are prepared by means of doping g-C 3 N 4 in the process of ZIF-67 formation and then introducing MoS 2 nanoparticles on the surface of collaborative structure between MOFs and g-C 3 N 4 . The MOFs (ZIF-67) and g-C 3 N 4 catalyst-modified MoS 2 photocatalyst exhibits efficient hydrogen production with about 321 μmol under visible light irradiation in 4 h, which is almost about 30 times higher than that of over the pure g-C 3 N 4 photocatalyst. A series of characterization studies such as SEM, XRD, TEM, EDX, XPS, UV–vis DRS, FTIR, transient fluorescence and electro-chemistry show that the novel structure of g-C 3 N 4 and MOF is formed, the more active sites appears and the efficiency of photo-generated charge separation is improved. MoS 2 , as a narrow band semiconductor, is grafted on the surface of g-C 3 N 4 /MOF, which could effectively harvest visible light and swift charge separation. The results are well mutual corroboration with each other. In addition, a eosin Y-sensitized reaction mechanism is introduced. [ABSTRACT FROM AUTHOR]

The composite photocatalyst Ni x Mo 1−x S 2 /MOF-5@g-C 3 N 4 was successfully synthesized by means of hydrothermal with two step methods and the effective photocatalytic activity improvement was obtained. With the introduction of Ni x Mo 1−x S 2 , the H 2 production reached the maximum about 319 μmol under continuous visible light irradiation for 5 h, which was 30 times higher than that of pure g-C 3 N 4 photocatalyst. A series of characterization results shown that the MOF-5@g-C 3 N 4 on the surface of Ni x Mo 1−x S 2 provided the more active sites and improved the efficiency of photo-generated charge separation with SEM, XRD, TEM, EDX, XPS, UV–vis DRS, BET, FTIR, transient fluorescence and electro-chemistry etc. and the results of which were in good mutual corresponding with each other. Furthermore, the reaction mechanism over the compound catalyst Ni x -Mo 1−x S 2 /MOF-5@g-C 3 N 4 was proposed. [ABSTRACT FROM AUTHOR]