1. Effects of AIT-082, a purine derivative, on tremor induced by arecoline or oxotremorine in mice
- Author
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Zhang Shoulan, Lin Fusheng, Lei Guangqing, Gao Nan-nan, and Yang Runmei
- Subjects
Male ,Parkinson's disease ,Arecoline ,Pharmacology ,Muscarinic Agonists ,chemistry.chemical_compound ,Mice ,Intragastric administration ,Tremor ,medicine ,Oxotremorine ,Animals ,Aminobenzoates ,Hypoxanthine ,Mice, Inbred ICR ,Dose-Response Relationship, Drug ,General Medicine ,medicine.disease ,Dose–response relationship ,chemistry ,Hypoxanthines ,Purine derivative ,medicine.drug - Abstract
The effects of AIT-082, a hypoxanthine derivative, on tremor in mice were investigated. The mice received intragastric administration of AIT-082 for consecutive 60 days at doses of 150, 300 and 600 mg·kg–1. The results showed that AIT-082 not only effectively inhibited the tremor induced by arecoline or oxotremorine, but also alleviated the tremor intensity and significantly shortened the tremor durations. The inhibition of tremor was perhaps associated with the central cholinergic nerve depressant effects as well as the stimulation of proliferation and differentiation of nerve cells.
- Published
- 2006