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Your search keyword '"Motoike, Toshiyuki"' showing total 4 results
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4 results on '"Motoike, Toshiyuki"'

3. A Neuropeptide Ligand of the G Protein-Coupled Receptor GPR103 Regulates Feeding, Behavioral Arousal, and Blood Pressure in Mice

Author

Takayasu, Shinobu, Sakurai, Takeshi, Iwasaki, Satoshi, Teranishi, Hitoshi, Yamanaka, Akihiro, Williams, S. Clay, Iguchi, Haruhisa, Kawasawa, Yuka Imamura, Ikeda, Yukio, Sakakibara, Iori, Ohno, Kousaku, Ioka, Ryoichi X., Murakami, Saori, Dohmae, Naoshi, Xie, Jian, Suda, Toshihiro, Motoike, Toshiyuki, Ohuchi, Takashi, Yanagisawa, Masashi, and Sakai, Juro

Published
2006
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4. Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice.

Author

Cera, Maria Rosaria, Prete, Annalisa Del, Vecchi, Annunciata, Corada, Monica, Martin-Padura, Ines, Motoike, Toshiyuki, Tonetti, Paolo, Bazzoni, Gianfranco, Vermi, William, Gentili, Francesca, Bernasconi, Sergio, Sato, Thomas N., Mantovani, Alberto, Dejana, Elisabetta, and Del Prete, Annalisa

Subjects
*JUNCTIONAL complexes (Epithelium), *LYMPH nodes, *CONTACT dermatitis, *CELL adhesion molecules, *IMMUNITY, *LABORATORY mice, *ANIMAL experimentation, *CELL motility, *COMPARATIVE studies, *DENDRITIC cells, *EPITHELIAL cells, *FLUORESCENT antibody technique, *MICE, *RESEARCH funding
Abstract

Junctional adhesion molecule-A (JAM-A) is a transmembrane adhesive protein expressed at endothelial junctions and in leukocytes. In the present work, we found that DCs also express JAM-A. To evaluate the biological relevance of this observation, Jam-A(-/-) mice were generated and the functional behavior of DCs in vitro and in vivo was studied. In vitro, Jam-A(-/-) DCs showed a selective increase in random motility and in the capacity to transmigrate across lymphatic endothelial cells. In vivo, Jam-A(-/-) mice showed enhanced DC migration to lymph nodes, which was not observed in mice with endothelium-restricted deficiency of the protein. Furthermore, increased DC migration to lymph nodes was associated with enhanced contact hypersensitivity (CHS). Adoptive transfer experiments showed that JAM-A-deficient DCs elicited increased CHS in Jam-A(+/+) mice, further supporting the concept of a DC-specific effect. Thus, we identified here a novel, non-redundant role of JAM-A in controlling DC motility, trafficking to lymph nodes, and activation of specific immunity. [ABSTRACT FROM AUTHOR]

Published
2004
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