1. Epigallocatechin-3-gallate (EGCG), A Green Tea Polyphenol, Suppresses Hepatic Gluconeogenesis through 5′-AMP-activated Protein Kinase
- Author
-
Michael J. Quon, Qu Fan Collins, Zhenqi Liu, Jingbo Pi, Hui Yu Liu, and Wenhong Cao
- Subjects
AMP-Activated Protein Kinases ,Protein Serine-Threonine Kinases ,Pharmacology ,Models, Biological ,complex mixtures ,Biochemistry ,Article ,Antioxidants ,Catechin ,5'-AMP-Activated Protein Kinase ,Mice ,AMP-activated protein kinase ,Multienzyme Complexes ,Animals ,Insulin ,heterocyclic compounds ,RNA, Small Interfering ,Protein kinase A ,Molecular Biology ,chemistry.chemical_classification ,Reactive oxygen species ,Tea ,biology ,Kinase ,Gluconeogenesis ,food and beverages ,AMPK ,Hydrogen Peroxide ,Cell Biology ,Liver ,chemistry ,Hepatocytes ,biology.protein ,sense organs ,Signal transduction ,Reactive Oxygen Species ,Signal Transduction - Abstract
Epigallocatechin-3-gallate (EGCG), a main catechin of green tea, has been suggested to inhibit hepatic gluconeogenesis. However, the exact role and related mechanism have not been established. In this study, we examined the role of EGCG in hepatic gluconeogenesis at concentrations that are reachable by ingestion of pure EGCG or green tea, and are not toxic to hepatocytes. Our results show in isolated hepatocytes that EGCG at relatively low concentrations (
- Published
- 2007