1. More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis.
- Author
-
Pittaluga E, Costa G, Krasnowska E, Brunelli R, Lundeberg T, Porpora MG, Santucci D, and Parasassi T
- Subjects
- Acetylcysteine pharmacology, Animals, Antioxidants pharmacology, Cell Differentiation drug effects, Cell Differentiation genetics, Cell Movement drug effects, Cell Movement genetics, Cell Proliferation drug effects, Cytostatic Agents pharmacology, Cytostatic Agents therapeutic use, Drug Evaluation, Preclinical, Endometriosis genetics, Endometriosis metabolism, Endometriosis pathology, Female, Inflammation genetics, Inflammation Mediators metabolism, Mice, Inbred BALB C, Peritoneal Diseases genetics, Peritoneal Diseases metabolism, Peritoneal Diseases pathology, Acetylcysteine therapeutic use, Antioxidants therapeutic use, Disease Models, Animal, Endometriosis drug therapy, Mice, Peritoneal Diseases drug therapy
- Abstract
N-acetyl-L-cysteine exerts a complex action on endometrial cells, involving regulation of gene expression and protein activity and location, all converging into a decreased proliferation and a switch toward a differentiating, less invasive, and less inflammatory phenotype. Also considering the lack of undesired side effects, including unaffected fertility potential, this suggests a beneficial use of NAC in endometriosis clinical treatment., (Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Published
- 2010
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