1. Red Light‐Triggered Intracellular Carbon Monoxide Release Enables Selective Eradication of MRSA Infection
- Author
-
Jinming Hu, Guihai Gan, Jian Cheng, Zhiqiang Shen, Lei Gao, and Guoying Zhang
- Subjects
Methicillin-Resistant Staphylococcus aureus ,Staphylococcus aureus ,Light ,Metal carbonyl ,010402 general chemistry ,Skin Diseases ,01 natural sciences ,Micelle ,Catalysis ,Mice ,chemistry.chemical_compound ,Escherichia coli ,Animals ,Red light ,Micelles ,Carbon Monoxide ,Wound Healing ,Photosensitizing Agents ,biology ,010405 organic chemistry ,General Medicine ,General Chemistry ,Antimicrobial ,biology.organism_classification ,Anti-Bacterial Agents ,0104 chemical sciences ,Drug Liberation ,chemistry ,Spectrophotometry ,Flavanones ,Biophysics ,Photooxygenation ,Oxidation-Reduction ,Bacteria ,Intracellular ,Carbon monoxide - Abstract
Carbon monoxide (CO) is an important gaseous signaling molecule. The use of CO-releasing molecules such as metal carbonyls enables the elucidation of the pleiotropic functions of CO. Although metal carbonyls show a broad-spectrum antimicrobial activity, it remains unclear whether the bactericidal property originates from the transition metals or the released CO. Here, we develop nonmetallic CO-releasing micelles via a photooxygenation mechanism of 3-hydroxyflavone derivatives, enabling CO release under red light irradiation (e.g., 650 nm). Unlike metal carbonyls that non-specifically internalize into both Gram-positive and Gram-negative bacteria, the nonmetallic micelles are selectively taken up by S. aureus instead of E. coli cells, exerting a selective bactericidal effect. Further, we demonstrate that the CO-releasing micelles can cure methicillin-resistant S. aureus (MRSA)-infected wounds, simultaneously eradicating MRSA pathogens and accelerating wound healing.
- Published
- 2021