1. Interlayer-crosslinked micelles prepared from star-shaped copolymers via click chemistry for sustained drug release.
- Author
-
Zhang X, Wang H, and Dai Y
- Subjects
- Animals, COS Cells, Cell Survival, Chlorocebus aethiops, Dynamic Light Scattering, Methotrexate pharmacology, Particle Size, Polyethylene Glycols chemical synthesis, Polyethylene Glycols chemistry, Proton Magnetic Resonance Spectroscopy, Spectroscopy, Fourier Transform Infrared, Click Chemistry methods, Cross-Linking Reagents chemistry, Drug Liberation, Micelles, Polymers chemistry
- Abstract
To balance the stability and the particle size of polymeric micelles, star-shaped copolymers Hx-yne-N
3 -PEG containing both alkynyl and azido groups were synthesized from hyperbranched 2,2-bismethylolpropionic acid polyester (H20 with 16 hydroxyl, H30 with 32 hydroxyl, H40 with 64 hydroxyl) to develop interlayer-crosslinked micelles by click chemistry. The results of dynamic light scattering indicate that the crosslinking could enhance the stability of polymeric micelles. The crosslinked micelles are regular nanosized (approximately 20 nm) spheres observed by a transmission electron microscope. The crosslinked micelles have better drug loading capacity and more sustained drug release behavior than the un-crosslinked micelles.- Published
- 2017
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