1. Eugenia Pohliana Leaves Essential Oil Inhibits Fungal Virulence and Restores Antibiotic Efficacy in Multidrug-Resistant Bacterial Strains.
- Author
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da Costa Silva JT, Almeida Menezes S, Pereira da Cruz R, Cortez Sombra Vandesmet L, Tereza Dos Santos Correia M, da Silva MV, Luiz Silva Pereira R, Figueirêdo Dos Santos MA, Rodrigues Costa A, da Silva VB, Gregorio de Oliveira M, Walber Gonçalves Castro J, Augusta de Sousa Fernandes P, da Silva Júnior EG, Douglas Melo Coutinho H, Mariana Gonçalves Lima C, Flaviana Bezerra Morais-Braga M, and Weverton Almeida-Bezerra J
- Subjects
- Candida albicans drug effects, Staphylococcus aureus drug effects, Drug Resistance, Multiple, Bacterial drug effects, Virulence drug effects, Candida tropicalis drug effects, Oils, Volatile pharmacology, Oils, Volatile chemistry, Oils, Volatile isolation & purification, Plant Leaves chemistry, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents isolation & purification, Microbial Sensitivity Tests, Eugenia chemistry, Antifungal Agents pharmacology, Antifungal Agents chemistry, Antifungal Agents isolation & purification
- Abstract
This study aims to investigate the essential oil from leaves of Eugenia pohliana (EOEP) in regard to its chemical composition, antimicrobial and drug-enhancing activity, as well as the reduction of fungal virulence capacity. Chemical characterization using GC-MS showed as major components the sesquiterpenes δ-cadinene, Epi-α-Muurolol, and bicyclogermacrene. The results of antibacterial tests indicated that Staphylococcus aureus was more sensitive to EOEP, that also enhanced the efficacy of gentamicin, erythromycin, and norfloxacin. EOEP exhibited antifungal properties against Candida albicans, in addition to potentiating the effectiveness of fluconazole against Candida tropicalis. It showed anti-virulence effects in all fungal strains. These findings underscore E. pohliana as a potential candidate for the prospection of novel therapeutic agents to treat infectious diseases caused by resistant microbes., (© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
- Published
- 2024
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