1. The role of microbiota in the development of colorectal cancer.
- Author
-
Dai Z, Zhang J, Wu Q, Chen J, Liu J, Wang L, Chen C, Xu J, Zhang H, Shi C, Li Z, Fang H, Lin C, Tang D, and Wang D
- Subjects
- Carcinogenesis genetics, Colorectal Neoplasms genetics, Colorectal Neoplasms therapy, Epigenesis, Genetic, Fecal Microbiota Transplantation methods, Fecal Microbiota Transplantation trends, Host-Pathogen Interactions, Humans, Intestines pathology, Colorectal Neoplasms microbiology, Feces microbiology, Gastrointestinal Microbiome physiology, Intestines microbiology, Microbiota physiology
- Abstract
Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely related to the intestinal microbiota. Many reports and clinical studies have shown that intestinal microbial behavior may lead to pathological changes in the host intestines. The changes can be divided into epigenetic changes and carcinogenic changes at the gene level, which ultimately promote the production and development of colorectal cancer. This article reviews the pathways of microbial signaling in the intestinal epithelial barrier, the role of microbiota in inflammatory colorectal tumors, and typical microbial carcinogenesis. Finally, by gaining a deeper understanding of the intestinal microbiota, we hope to achieve the goal of treating colorectal cancer using current microbiota technologies, such as fecal microbiological transplantation., (© 2018 UICC.)
- Published
- 2019
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