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Pharmaceutically active compounds risperidone has difficulty to be packaged into nanocarrier due to its positive charge. In this study, we encapsulated risperidone into chitosan-based nanocarrier via ionic interaction. The nanocarrier was consisted of chitosan:sodium TPP = 5.72:1 and prepared by ionic gelation method. Encapsulation efficiency was enhanced by modification of pH of chitosan, sodium tripolyphosphate (TPP), and the concentration as well as the surface charge of risperidone. The later was done by addition of SDS (Sodium Dodecyl Sulphate) minimum 0.005% (w/v). The particle size was in the range of 300-400 nm. Encapsulation efficiency of risperidone was reached up to 25.62% with addition of 0.050% SDS. Encapsulation of risperidone into chitosan-TPP nanocarrier was increased by modification of risperidone's charge with low concentration of SDS. Further amount of SDS higher than 0.1% increased the particle size to microparticles. Chitosan-based type nanocarrier was preferable for encapsulating anionic drugs via ionic interaction. [ABSTRACT FROM AUTHOR]