1. Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques.
- Author
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Barcia C, Ros CM, Ros-Bernal F, Gómez A, Annese V, Carrillo-de Sauvage MA, Yuste JE, Campuzano CM, de Pablos V, Fernández-Villalba E, and Herrero MT
- Subjects
- Animals, Female, Macaca fascicularis, Male, Microglia metabolism, Microglia pathology, Parkinson Disease metabolism, Parkinson Disease pathology, Phagocytes metabolism, Phagocytes pathology, Substantia Nigra metabolism, Substantia Nigra pathology, Time Factors, Microglia immunology, Parkinson Disease immunology, Phagocytes immunology, Phagocytosis immunology, Substantia Nigra immunology
- Abstract
Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, but it is thought that this persistent microglial activation may contribute to the degeneration of dopaminergic neurons. In this study, we report the microanatomical details of microglia and the relationship between microglia and neurons in the substantia nigra pars compacta of Parkinsonian monkeys years after insult with MPTP. We observed that microglial cells appear polarized toward dopaminergic neurons in MPTP-treated macaques compared to untreated animals and present clear phagocytic characteristics, such as engulfing gliaptic contacts, an increase in Golgi apparatus protein machinery and ball-and-chain phagocytic buds. These results demonstrate that activated microglia maintain phagocytic characteristics years after neurotoxin insult, and phagocytosis may be a key contributor to the neurodegenerative process., (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Published
- 2013
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