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Objective: To compare the efficacy of topical 0.05% Isotretinoin gel versus 0.1% Adapalene gel in treating mild to moderate acne vulgaris. Study Design: Quasi-Experimental study. Place and Duration of Study: Department of Dermatology, Pak Emirates Military Hospital (PEMH), Rawalpindi Pakistan, From Feb to Jul 2018. Methodology: A total of ninety-two patients aged 12 to 25 years with mild to moderate facial acne vulgaris were enrolled and divided into two treatment Groups, Group-A (0.05% Isotretinoin Gel) and Group-B (0.1% Adapalene Gel). Efficacy was measured at 12 weeks post-treatment. Results: Treatment was found efficacious in 84.8% (n=39/46) of patients in Group-A and 50.0% (n=23/46) of patients in Group-B (p= 0.001). There were similar results when treatment efficacy in both Groups was disease severity. In all cases, efficacy was better in Group-A (p<0.05). Conclusions: The efficacy of topical 0.05% Isotretinoin gel was better than topical 0.1% Adapalene gel for treating mild to moderate acne vulgaris. [ABSTRACT FROM AUTHOR]

Objective: To compare the reduction in mean pain score with local Methylcobalamin injection versus local Bupivacaine injection in patients with acute herpetic neuralgia. Study Design: Quasi experimental study. Place and Duration of Study: Dermatology Outpatient Department, Pak Emirates Military Hospital, Rawalpindi, from Jun to Dec 2019. Methodology: Total 100 patients, having pain score more than 3, fulfilling the selection criteria were divided into two groups. Group A was treated with daily subcutaneous injection Bupivacaine, whereas Group B was treated with daily subcutaneous injection Methycobalamin at the site of neuralgia. Patients were followed up for 4 weeks. The pain score was noted. All the data was entered and analyzed on SPSS version 21. Results: In this study mean age of patients in group A was 43.82 ± 15.76 years and in group B was 44.76 ± 16.92 years. The mean visual analogue pain score at 4th week in the group A patients was 1.14 ± 0.32 and in group B was 1.90 ± 0.97. Statistically significant difference was found in group A (local Bupivacaine) with visual analogue score (VAS) at 4th week (pvalue= 0.002). Conclusion: The local Bupivacaine injection showed significant reduction in mean pain score than local Methylcobalamin injection in patients with acute herpetic neuralgia. [ABSTRACT FROM AUTHOR]

Objective: To compare oral azithromycin with doxycycline in treatment of moderate acne vulgaris. Study Design: Randomized control trial. Place and Duration of Study: Department of Dermatology, Pak Emirates Military Hospital (PEMH), Rawalpindi, Aug 2017 to Jan 2018. Methodology: A total of 92 patients with moderate Acne were selected from Dermatology outpatient department (OPD) PEMH, after written informed consent. Patients were arbitrarily allocated by lottery method to one of the two treatment groups: group A/B. Group A was given Azithromycin 500 mg daily for four consecutive days each month for 03 months & group B was given Doxycycline 100 mg daily for 03 months. Patients were reviewed monthly for 03 months & acne severity index (ASI) was recorded at baseline, at 01 month and 03 months. Primary outcome measured was more than 50% decrease from baseline in acne severity index within 03 months of treatment, using global acne grading system (GAGS). Results: Total 92 patients equally divided in Azithromycin (A) and Doxycycline (B) groups were enrolled. Mean age of group A & B were 21.80 ± 4.64 and 21.61 ± 4.48 years respectively. In group A mean pre-treatment acne severity index was 24.83 + 3.15 & mean post-treatment ASI was 10.15 ± 1.7. In group B mean pre-treatment acne severity index was 25.30 ± 2.96 & mean post-treatment acne severity index was 9.86 ± 1.58. Conclusion: Azithromycin was found comparable to Doxycycline in terms of mean change in acne severity index, in treatment of moderate acne vulgaris. [ABSTRACT FROM AUTHOR]

Objective: To compare oral Montelukast with oral Doxycycline in the treatment of moderate Acne Vulgaris in terms of mean change in acne severity index. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Dermatology, Pak Emirates Military Hospital Rawalpindi, from Mar 2016 to Aug 2016. Methodology: A total of 84 patients were included in the study. They were randomly assigned to group A and B by consecutive non probability sampling technique. Group A was given 100mg Doxycycline with topical 10% benzoyl peroxide and group B was given 5mg Montelukast with topical 10% benzoyl peroxide. Acne severity index (ASI) was calculated at base line and after one month. Mean change in acne severity index was observed for both the groups. Results: Independent sample t-test was used to compare the means. Mean post treatment change in acne severity index of group A was 5.45 ± 1.29 and group B was 1.80 ± .59 respectively (p-value <0.001). On post stratification analysis for age and gender results were consistent. Conclusion: Efficacy of Doxycycline is significantly better in terms of mean change in Acne Severity Index, as compared to Montelukast. [ABSTRACT FROM AUTHOR]

Objective: To compare the frequency of success of intralesional vitamin D3 versus cryotherapy for management of patients with plantar warts. Study Design: Quasi experimental study. Place and Duration of Study: Department of Dermatology, Pak Emirates Military Hospital, Rawalpindi, from Aug 2016 to Feb 2017. Methodology: Total 60 patients, fulfilling the selection criteria, were included in the study. The patients were randomly divided in two groups by using lottery method. In group 1, Vitamin D3 was injected into the base of the warts after local anaesthetic agent, prilocaine. In group 2, cryotherapy was done by using a high-intensity regimen of one session every two weeks till 6 weeks. All patients were followed-up in Out-Patient Department (OPD) for 13 weeks. After 13 weeks, condition of warts was assessed. In case of complete resolution of warts, the success was labeled. Results: In this study success rate of intralesional D3 was 63.3% and for cryotherapy success rate was 43.3% (p-value=0.121). Stratification of age and gender did not show any statistically significant difference between success rates of both treatment modalities. However patients with history of shorter duration ranging in between 11-15 days showed significant higher success rate for intralesional vitamin-D3 as compared to cryotherapy. Conclusion: Frequency of success of intralesional vitamin-D3 was more than that of cryotherapy for treating planter warts. [ABSTRACT FROM AUTHOR]