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Objective: The main objective of this study was to evaluate the efficacy of tamsulosin or mirabegron on ureteral stent‐related symptoms. Patients and methods: This was a prospective, randomized, controlled, and single‐blinded study. In total, 180 patients who had undergone ureterolithotripsy and ureteral stent insertion were included. Patients were randomly divided into three groups as follows: Group 1 was the control group taking placebo; group 2 was administered tamsulosin (0.4 mg) once a day; and group 3 received mirabegron (50 mg) once a day. The Turkish version of the ureteral stent symptom questionnaire was filled out after 4 weeks. Results: After excluding patients who were lost to follow‐up, 161 patients were included in the final analysis. Analgesic usage doses were lower in the tamsulosin (5.1 ± 1.8) and mirabegron (4.5 ± 1.4) groups than in the control group (5.9 ± 2.1; P <.001). The urinary symptoms score was lower in tamsulosin group than it was in the control group (22.1 vs 27.8; P =.001); however, the other scores (body pain, general health, work performance, sexual matters, and other problems) were similar between the groups. Conclusions: Tamsulosin improves only urinary symptoms due to the ureteral stent and decreases the need for analgesics. Mirabegron has no effect on ureteral stent‐related symptoms, but it decreases analgesic need. [ABSTRACT FROM AUTHOR]