1. The Significance of Mitochondrial Dysfunction in Cancer.
- Author
-
Luo Y, Ma J, and Lu W
- Subjects
- Apoptosis genetics, Energy Metabolism genetics, Humans, Mitochondria genetics, Mitochondria pathology, Mutation genetics, Neoplasms metabolism, Neoplasms pathology, Oxidation-Reduction, DNA, Mitochondrial genetics, Mitochondria metabolism, Neoplasms genetics, Oxidative Stress genetics
- Abstract
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in energy metabolism, maintenance of redox balance, and regulation of apoptosis. Mitochondrial dysfunction, either due to the TCA cycle enzyme defects, mitochondrial DNA genetic mutations, defective mitochondrial electron transport chain, oxidative stress, or aberrant oncogene and tumor suppressor signaling, has been observed in a wide spectrum of human cancers. In this review, we summarize mitochondrial dysfunction induced by these alterations that promote human cancers.
- Published
- 2020
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