1. Sex-dependent differences in macaque brain mitochondria.
- Author
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Guerrero I, Yoval-Sánchez B, Konrad C, Manfredi G, Wittig I, and Galkin A
- Subjects
- Animals, Male, Female, Macaca mulatta, Electron Transport Complex IV metabolism, Sex Characteristics, Oxidative Phosphorylation, Ketoglutarate Dehydrogenase Complex metabolism, Electron Transport Complex I metabolism, Energy Metabolism, Mitochondria metabolism, Brain metabolism
- Abstract
Mitochondrial bioenergetics in females and males is different. However, whether mitochondria from male and female brains display differences in enzymes of oxidative phosphorylation remains unknown. Therefore, we characterized mitochondrial complexes from the brains of male and female macaques (Macaca mulatta). Cerebral tissue from male macaques exhibits elevated content and activity of mitochondrial complex I (NADH:ubiquinone oxidoreductase) and higher activity of complex II (succinate dehydrogenase) compared to females. No significant differences between sexes were found in the content of α-ketoglutarate dehydrogenase or in the activities of cytochrome c oxidase and F
1 Fo ATPase. Our results underscore the need for further investigations to elucidate sex-related mitochondrial differences in humans., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)- Published
- 2024
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