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Start Over Descriptor "NDUFS3 SUBUNIT" Topic mitochondrial complex i
2 results on '"NDUFS3 SUBUNIT"'

1. Mitochondrial proteome analysis reveals depression of the Ndufs3 subunit and activity of complex I in diabetic rat brain

Author

Taurino, Federica, Stanca, Eleonora, Siculella, Luisa, Trentadue, Raffaella, Papa, Sergio, Zanotti, Franco, and Gnoni, Antonio

Subjects
*MITOCHONDRIAL proteins, *PROTEOMICS, *DIABETES, *NADH dehydrogenase, *LABORATORY rats, *HYPERGLYCEMIA, *BRAIN physiology
Abstract

Abstract: Type-1 diabetes resulting from defective insulin secretion and consequent hyperglycemia, is associated with “diabetic encephalopathy.” This is characterized by brain neurophysiological and structural changes resulting in impairment of cognitive function. The present proteomic analysis of brain mitochondrial proteins from streptozotocin-induced type-1 diabetic rats, shows a large decrement of the Ndufs3 protein subunit of complex I, decreased level of the mRNA and impaired catalytic activity of the complex in the diabetic rats as compared to controls. The severe depression of the expression and enzymatic activity of complex I can represent a critical contributing factor to the onset of the diabetic encephalopathy in type-1 diabetes. [Copyright &y& Elsevier]

Published
2012
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2. Mitochondrial proteome analysis reveals depression of the Ndufs3 subunit and activity of complex I in diabetic rat brain

Author

Raffaella Trentadue, Antonio Gnoni, Federica Taurino, Luisa Siculella, Eleonora Stanca, Sergio Papa, Franco Zanotti, Taurino, F, Stanca, Eleonora, Siculella, Luisa, Trentadue, R, Papa, S, Zanotti, F, and Gnoni, A.

Subjects
Male, medicine.medical_specialty, Diabetic encephalopathy, Proteome, Diabetic rat, Protein subunit, Biophysics, Down-Regulation, Mitochondrial complex I, Biology, Models, Biological, Biochemistry, Streptozocin, Diabetes Mellitus, Experimental, Mitochondrial Proteins, Internal medicine, Diabetes mellitus, Type-1 diabete, medicine, Animals, Rats, Wistar, Depression (differential diagnoses), Brain Chemistry, chemistry.chemical_classification, Type 1 diabetes, Messenger RNA, Electron Transport Complex I, Brain Diseases, Metabolic, Brain, NADH Dehydrogenase, Brain mitochondrial proteome, medicine.disease, Ndufs3 subunit, Rats, Enzyme Activation, Protein Subunits, Diabetes Mellitus, Type 1, Enzyme, Endocrinology, chemistry
Abstract

Type-1 diabetes resulting from defective insulin secretion and consequent hyperglycemia, is associated with “diabetic encephalopathy.” This is characterized by brain neurophysiological and structural changes resulting in impairment of cognitive function. The present proteomic analysis of brain mitochondrial proteins from streptozotocin-induced type-1 diabetic rats, shows a large decrement of the Ndufs3 protein subunit of complex I, decreased level of the mRNA and impaired catalytic activity of the complex in the diabetic rats as compared to controls. The severe depression of the expression and enzymatic activity of complex I can represent a critical contributing factor to the onset of the diabetic encephalopathy in type-1 diabetes.

Published
2012

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