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Your search keyword '"François Kimmig"' showing total 4 results
Start Over Author "François Kimmig" Topic modeling and simulation
4 results on '"François Kimmig"'

1. Varying thin filament activation in the framework of the Huxley'57 model

Author

François Kimmig, Matthieu Caruel, Dominique Chapelle, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire Modélisation et Simulation Multi-Echelle (MSME), and Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel

Subjects
Sarcomeres, Applied Mathematics, Biomedical Engineering, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Cardiac modeling, Actins, Actin Cytoskeleton, Computational Theory and Mathematics, Thick and thin filament activation, Modeling and Simulation, Huxley'57 model, Calcium, Mathematical modeling, Molecular Biology, Software, Muscle Contraction
Abstract

International audience; Muscle contraction is triggered by the activation of the actin sites of the thin filament by calcium ions. It results that the thin filament activation level varies over time. Moreover, this activation process is also used as a regulation mechanism of the developed force. Our objective is to build a model of varying actin site activation level within the classical Huxley'57 two-state framework. This new model is obtained as an enhancement of a previously proposed formulation of the varying thick filament activation within the same framework [1]. We assume that the state of an actin site depends on whether it is activated and whether it forms a cross-bridge with the associated myosin head, which results in four possible states. The transitions between the actin site states are controlled by the global actin sites activation level and the dynamics of these transitions is coupled with the attachment-detachment process. A preliminary calibration of the model with experimental twitch contraction data obtained at varying sarcomere lengths is performed.

Published
2022
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2. Coupling reduced-order blood flow and cardiac models through energy-consistent strategies: modeling and discretization

Author

Sébastien Imperiale, François Kimmig, Federica Caforio, Philippe Moireau, Jessica Manganotti, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Karl-Franzens-Universität Graz, École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, and Institute of Mathematics and Scientific Computing, University of Graz

Subjects
Work (thermodynamics), Reduced-order models, Heart models, Discretization, Quantitative Biology::Tissues and Organs, 0206 medical engineering, 02 engineering and technology, 030204 cardiovascular system & hematology, Energy-preserving time-scheme, Reduced order, Systems engineering, Cardiovascular modelling, 03 medical and health sciences, Arterial segment, TA168, 0302 clinical medicine, Computational Science and Engineering, Engineering (miscellaneous), Physics, Coupling, Applied Mathematics, Mechanics of engineering. Applied mechanics, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Mechanics, Blood flow, TA349-359, Dicrotic notch, 020601 biomedical engineering, Computer Science Applications, Shallow-water models, Ageing, Modeling and Simulation, Energy (signal processing), [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract

In this work we provide a novel energy-consistent formulation for the classical 1D formulation of blood flow in an arterial segment. The resulting reformulation is shown to be suitable for the coupling with a lumped (0D) model of the heart that incorporates a reduced formulation of the actin-myosin interaction. The coupling being consistent with energy balances, we provide a complete heart-circulation model compatible with thermodynamics hence stable numerically and informative physiologically. These latter two properties are verified by numerical experiments.

Published
2021
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3. Hierarchical modeling of force generation in cardiac muscle

Author

Matthieu Caruel, François Kimmig, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire Modélisation et Simulation Multi-Echelle (MSME), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université Gustave Eiffel, École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris

Subjects
Sarcomeres, Process (engineering), Computer science, Calibration (statistics), media_common.quotation_subject, Fidelity, Context (language use), computer.software_genre, Models, Biological, 03 medical and health sciences, 0302 clinical medicine, model reduction, Humans, Computer Simulation, muscle modeling, Set (psychology), Microscale chemistry, 030304 developmental biology, media_common, Mechanical Phenomena, 0303 health sciences, Stochastic Processes, Hierarchy (mathematics), Mechanical Engineering, Myocardium, sliding filaments, Models, Cardiovascular, Experimental data, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Heart, Models, Theoretical, Myocardial Contraction, Modeling and Simulation, cross-bridges, Calibration, Calcium, Data mining, Stress, Mechanical, sarcomere, computer, 030217 neurology & neurosurgery, Algorithms, Biotechnology, Muscle Contraction
Abstract

International audience; Performing physiologically relevant simulations of the beating heart in clinical context requires to develop detailed models of the microscale force generation process. These models however may reveal difficult to implement in practice due to their high computational costs and complex calibration. We propose a hierarchy of three interconnected muscle contraction models-from the more refined to the more simplified-that are rigorously and systematically related with each other, offering a way to select, for a specific application, the model that yields a good trade-off between physiological fidelity, computational cost and calibration complexity. The three models families are compared to the same set of experimental data to systematically assess what physiological indicators can be reproduced or not and how these indicators constrain the model parameters. Finally, we discuss the applicability of these models for heart simulation.

Published
2020
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4. Thermodynamic properties of muscle contraction models and associated discrete-time principles

Author

Dominique Chapelle, Philippe Moireau, François Kimmig, Mathematical and Mechanical Modeling with Data Interaction in Simulations for Medicine (M3DISIM), Laboratoire de mécanique des solides (LMS), École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris-Saclay, École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Mines Paris - PSL (École nationale supérieure des mines de Paris)

Subjects
Large class, 74F25 ·74H15 · 65M12 ·35Q79 and 92C45, Discretization, 02 engineering and technology, Clausius–Duhem inequality, 01 natural sciences, lcsh:TA168, muscle contraction, 0203 mechanical engineering, medicine, Computational Science and Engineering, Statistical physics, 0101 mathematics, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], Engineering (miscellaneous), thermodynamically consistent time-discretization, Mathematics, Clausius-Duhem inequality, Continuum mechanics, Applied Mathematics, sliding filaments, Computer Science Applications, 010101 applied mathematics, 020303 mechanical engineering & transports, Discrete time and continuous time, lcsh:Systems engineering, Modeling and Simulation, medicine.symptom, lcsh:Mechanics of engineering. Applied mechanics, lcsh:TA349-359, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA], Muscle contraction
Abstract

International audience; Considering a large class of muscle contraction models accounting for actin-myosin interaction, we present a mathematical setting in which solution properties can be established, including fundamental thermodynamic balances. Moreover, we propose a complete discretization strategy for which we are also able to obtain discrete versions of the thermodynamic balances and other properties. Our major objective is to show how the thermodynamics of such models can be tracked after discretization, including when they are coupled to a macroscopic muscle formulation in the realm of continuum mechanics. Our approach allows to carefully identify the sources of energy and entropy in the system, and to follow them up to the numerical applications.

Published
2019
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