Drought, characterized by frequent occurrences, an extended duration, and a wide range of destruction, has become one of the natural disasters posing a significant threat to both socioeconomic progress and agricultural livelihoods. Large-scale geographical environments often exhibit obvious spatial heterogeneity, leading to significant spatial differences in drought's development and outcomes. However, traditional drought monitoring models have not taken into account the impact of regional spatial heterogeneity on drought, resulting in evaluation results that do not match the actual situation. In response to the above-mentioned issues, this study proposes the establishment of ecological–geographic zoning to adapt to the spatially stratified heterogeneous characteristics of large-scale drought monitoring. First, based on the principles of ecological and geographical zoning, an appropriate index system was selected to carry out ecological and geographical zoning for Yunnan Province. Second, based on the zoning results and using data from NASA's Moderate Resolution Imaging Spectroradiometer (MODIS) and the Tropical Rainfall Measuring Mission (TRMM) 3B43, the vegetation condition index (VCI), the temperature condition index (TCI), the precipitation condition index (TRCI), and three topographic factors including the digital elevation model (DEM), slope (SLOPE), and aspect (ASPECT) were selected as model parameters. Multiple linear regression models were then used to establish integrated drought monitoring frameworks at different eco–geographical zoning scales. Finally, the standardized precipitation evapotranspiration index (SPEI) was used to evaluate the monitoring effects of the model, and the spatiotemporal variation patterns and characteristics of winter and spring droughts in Yunnan Province from 2008–2019 were further analyzed. The results show that (1) compared to the traditional non-zonal models, the drought monitoring model constructed based on ecological–geographic zoning has a higher correlation and greater accuracy with the SPEI and (2) Yunnan Province experiences periodic and seasonal drought patterns, with spring being the peak period of drought occurrence and moderate drought and light drought being the main types of drought in Yunnan Province. Therefore, we believe that ecological–geographic zoning can better adapt to geographical spatial heterogeneity characteristics, and the zonal drought monitoring model constructed can more effectively identify the actual occurrence of drought in large regions. This research finding can provide reference for the formulation of drought response policies in large-scale regions. [ABSTRACT FROM AUTHOR]