1. Mitochondria and Antibiotics: For Good or for Evil?
- Author
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Carmen J Pastor-Maldonado, José Antonio Sánchez-Alcázar, Suleva Povea-Cabello, Mónica Álvarez-Córdoba, Irene Villalón-García, Juan M. Suárez-Rivero, Alejandra Suárez-Carrillo, Marta Talaverón-Rey, Manuel Munuera-Cabeza, Ministerio de Sanidad (España), European Commission, Ministerio de Educación, Cultura y Deporte (España), Ministerio de Economía, Industria y Competitividad (España), Junta de Andalucía, Ministerio de Economía y Competitividad (España), Asociación de Enfermos de Patologías Mitocondriales (España), Asociación de Enfermos de Neurodegeneración con Acumulación Cerebral de Hierro (España), Federación Española de Enfermedades Raras, Fundación Merck Salud, and Real e Ilustre Colegio de Farmacéuticos de Sevilla
- Subjects
0301 basic medicine ,obesity ,Aging ,medicine.medical_specialty ,medicine.drug_class ,Antibiotics ,Transplants ,Global problem ,Context (language use) ,Review ,Biochemistry ,Microbiology ,antibiotics ,03 medical and health sciences ,0302 clinical medicine ,Antibiotic resistance ,Neoplasms ,medicine ,Humans ,cancer ,Intensive care medicine ,Molecular Biology ,mitochondrial diseases ,diabetes ,business.industry ,Mental Disorders ,neurodegeneration ,Neurodegenerative Diseases ,unfolded protein response ,QR1-502 ,Anti-Bacterial Agents ,Gastrointestinal Microbiome ,Clinical Practice ,mitochondria ,030104 developmental biology ,Muscle Fatigue ,Life expectancy ,business ,030217 neurology & neurosurgery - Abstract
© 2021 by the authors., The discovery and application of antibiotics in the common clinical practice has undeniably been one of the major medical advances in our times. Their use meant a drastic drop in infectious diseases-related mortality and contributed to prolonging human life expectancy worldwide. Nevertheless, antibiotics are considered by many a double-edged sword. Their extensive use in the past few years has given rise to a global problem: antibiotic resistance. This factor and the increasing evidence that a wide range of antibiotics can damage mammalian mitochondria, have driven a significant sector of the medical and scientific communities to advise against the use of antibiotics for purposes other to treating severe infections. Notwithstanding, a notorious number of recent studies support the use of these drugs to treat very diverse conditions, ranging from cancer to neurodegenerative or mitochondrial diseases. In this context, there is great controversy on whether the risks associated to antibiotics outweigh their promising beneficial features. The aim of this review is to provide insight in the topic, purpose for which the most relevant findings regarding antibiotic therapies have been discussed., This work was supported by FIS PI16/00786 (2016) and FIS PI19/00377 (2019) grants, Ministerio de Sanidad, Spain and Fondo Europeo de Desarrollo Regional (FEDER Unión Europea), Spanish Ministry of Education, Culture and Sport. This activity has been co-financed by the European Regional Development Fund (ERDF) and by the Regional Ministry of Economic Transformation, Industry, Knowledge and Universities of the Junta de Andalucía, within the framework of the ERDF Andalusia operational program 2014–2020 Thematic objective “01—Reinforcement of research, technological develop-ment and innovation” through the reference research project CTS-5725 and PY18-850. We acknowledge the support of “Ayudas para la Formación de Profesorado Universitario” (FPU/MINECO), AEPMI (Asociación de Enfermos de Patología Mitocondrial), ENACH (Asociación de enfermos de Neurodegeneración con Acumulación Cerebral de Hierro), FEDER (Federación Española de Enfermedades Raras), Yo Nemálínica Association, KAT6A Association, Fundación MERCK Salud and Fundación MEHUER/Colegio Oficial de Farmacéuticos de Sevilla.
- Published
- 2021