1. Aptamers: Functional-Structural Studies and Biomedical Applications.
- Author
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Troisi, Romualdo and Sica, Filomena
- Subjects
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APTAMERS , *MOLECULAR biology , *NON-coding RNA , *BLOOD coagulation factors , *VASCULAR dementia - Abstract
Aptamers are synthetic molecules of different natures (mostly, DNA or RNA) that recognize a target molecule with high affinity and specificity. Indeed, since the development of the systematic evolution of ligands by exponential enrichment (SELEX) procedure in the 1990s, several aptamers have been selected as biomedical agents or for the development of analytical methods. Finally, potential applications of aptamers for personalized gene therapy have recently been proposed including the use of functional RNA aptamers containing both lipid raft-targeting motif and a therapeutic motif to selectively introduce RNAs into exosomes [[10]]. [Extracted from the article]
- Published
- 2022
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