1. Effects of hydroxy-xanthones on dipalmitoylphosphatidylcholine lipid bilayers: A theoretical and experimental study.
- Author
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Sierra MB, Alarcón L, Gerbino D, Pedroni VI, Buffo FE, and Morini MA
- Subjects
- Chemical Phenomena drug effects, Temperature, 1,2-Dipalmitoylphosphatidylcholine chemistry, Lipid Bilayers chemistry, Molecular Dynamics Simulation, Xanthones chemistry, Xanthones pharmacology
- Abstract
Xanthones and derivatives are natural active compounds whose interest has been increased due to its several pharmacological effects. In this work, effects of hydroxy-xanthones on the physicochemical properties of dipalmitoylphosphatidylcholine (DPPC) liposomes have been investigated in terms of lipid bilayer fluidity, by means of molecular dynamics simulations and temperature dependence of zeta potential studies. Experimental results predict, in good agreement with simulations, that xanthones are able to be incorporated into DPPC liposomes with certain localization, fluidizing the bilayer. Both effects, localization and fluidity were found to be dependent of the number of hydroxilic substituents of the xanthone and the lipid phase state., (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Published
- 2017
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