1. Molecularly imprinted nanotubes for enantioselective drug delivery and controlled release.
- Author
-
Yin J, Cui Y, Yang G, and Wang H
- Subjects
- Animals, Cell Survival drug effects, Delayed-Action Preparations chemical synthesis, Delayed-Action Preparations pharmacokinetics, Delayed-Action Preparations toxicity, Drug Carriers toxicity, Hep G2 Cells, Humans, Models, Molecular, Molecular Conformation, Nanotubes toxicity, Propranolol chemistry, Propranolol pharmacokinetics, Rats, Stereoisomerism, Substrate Specificity, Delayed-Action Preparations chemistry, Drug Carriers chemical synthesis, Drug Carriers chemistry, Molecular Imprinting methods, Nanotubes chemistry
- Abstract
Molecularly imprinted nanotubes for enantioselective drug delivery and controlled release are fabricated by the combination of template synthesis and ATRP grafting. The release of R-propranolol from the imprinted nanotubes in rats is restricted while the release of pharmacologically active S-enantiomer is greatly promoted.
- Published
- 2010
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