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Your search keyword '"Dielectric analyses"' showing total 2 results
Start Over Descriptor "Dielectric analyses" Topic molecular mobility
2 results on '"Dielectric analyses"'

1. Chain dynamics of human dermis by Thermostimulated currents: A tool for new markers of aging.

Author

Samouillan, V., Tang, R., Dandurand, J., Lacabanne, C., Lacoste‐Ferré, M.‐H., Villaret, A., Nadal‐Wollbold, F., and Schmitt, A.‐M.

Subjects
*DERMIS, *SKIN aging, *HYDRATION, *DEHYDRATION, *AGING, *CYTOSKELETAL proteins, *INTRINSIC factor (Physiology)
Abstract

Background/purpose: The purpose of this clinical study was to identify dielectric markers to complete a previous thermal and vibrational study on the molecular and organizational changes in human dermis during intrinsic and extrinsic aging. Methods: Sun‐exposed and non‐exposed skin biopsies were collected from 28 women devised in two groups (20‐30 and ≥60 years old). The dielectric relaxation modes associated with localized and delocalized dynamics in the fresh and dehydrated state were determined by the Thermostimulated currents technique (TSC). Results: Intrinsic and extrinsic aging induced significant evolution of some of the dielectric parameters of localized and delocalized dynamics of human skin. With photo‐aging, freezable water forms a segregated phase in dermis and its dynamics is close to free water, what evidences the major role of extrinsic aging on water organization in human skin. Moreover, TSC indicators highlight the restriction of localized mobility with intrinsic aging due to glycation, and the cumulative effect of chronological aging and photo‐exposition on the molecular mobility of the main structural proteins of the dermis at the mesoscopic scale. Conclusion: TSC is a well‐suited technique to scan the molecular mobility of human skin. It can be uses as a relevant complement of vibrational and thermal characterization to follow human skin modifications with intrinsic and extrinsic aging. [ABSTRACT FROM AUTHOR]

Published
2019
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2. Chain dynamics of human dermis by Thermostimulated currents: A tool for new markers of aging

Author

Aurélie Villaret, Florence Nadal-Wollbold, Valérie Samouillan, Rong Tang, Marie-Hélène Lacoste-Ferré, Colette Lacabanne, Jany Dandurand, Anne-Marie Schmitt, Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Laboratoires Pierre Fabre, Centre interuniversitaire de recherche et d'ingenierie des matériaux ( CIRIMAT ), Institut National Polytechnique [Toulouse] ( INP ) -Université Paul Sabatier - Toulouse 3 ( UPS ) -Centre National de la Recherche Scientifique ( CNRS ), Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Laboratoires Pierre Fabre (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), and Institut National Polytechnique de Toulouse - INPT (FRANCE)

Subjects
Adult, Matériaux, Biopsy, Biochimie, Biologie Moléculaire, Hydration, Human skin, Dermatology, Dielectric, 01 natural sciences, Molecular mobility, 010309 optics, Clinical study, 030207 dermatology & venereal diseases, 03 medical and health sciences, Delocalized electron, Young Adult, 0302 clinical medicine, Age Distribution, Dermis, 0103 physical sciences, medicine, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Dielectric analyses, Aged, Skin, Dermatologie, Chemistry, Dynamics (mechanics), Relaxation (NMR), Electric Conductivity, [CHIM.MATE]Chemical Sciences/Material chemistry, Middle Aged, Intrinsic and extrinsic aging, Skin Aging, medicine.anatomical_structure, Human skin aging, [ CHIM.MATE ] Chemical Sciences/Material chemistry, Biophysics, Sunlight, Thermodynamics, Female, [ SDV.MHEP.DERM ] Life Sciences [q-bio]/Human health and pathology/Dermatology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology, Biomarkers
Abstract

International audience; Abstract Background/purpose: The purpose of this clinical study was to identify dielectric markers to complete a previous thermal and vibrational study on the molecular and organizational changes in human dermis during intrinsic and extrinsic aging. Methods: Sun-exposed and non-exposed skin biopsies were collected from 28 women devised in two groups (20-30 and ≥60 years old). The dielectric relaxation modes associated with localized and delocalized dynamics in the fresh and dehydrated state were determined by the Thermostimulated currents technique (TSC). Results: Intrinsic and extrinsic aging induced significant evolution of some of the dielectric parameters of localized and delocalized dynamics of human skin. With photo-aging, freezable water forms a segregated phase in dermis and its dynamics is close to free water, what evidences the major role of extrinsic aging on water organization in human skin. Moreover, TSC indicators highlight the restriction of localized mobility with intrinsic aging due to glycation, and the cumulative effect of chronological aging and photo-exposition on the molecular mobility of the main structural proteins of the dermis at the mesoscopic scale. Conclusion: TSC is a well-suited technique to scan the molecular mobility of human skin. It can be uses as a relevant complement of vibrational and thermal characterization to follow human skin modifications with intrinsic and extrinsic aging.

Published
2018
Full Text
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