1. Novel chaetospirolactone and orsellide F from an endophytic fungus <italic>Chaetomium</italic> sp.
- Author
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Xu, Qin-Lan, Xiao, Yong-Sheng, Shen, Ye, Wu, Hui-Min, Zhang, Xuan, Deng, Xin-Zhao, Wang, Ting-Ting, Li, Wei, Tan, Ren-Xiang, Jiao, Rui-Hua, and Ge, Hui-Ming
- Subjects
ORGANIC compound analysis ,ACETYLCHOLINESTERASE ,ALKALOIDS ,BIOLOGICAL assay ,CHOLINESTERASE inhibitors ,CHROMATOGRAPHIC analysis ,CRYSTALLOGRAPHY ,FUNGI ,MASS spectrometry ,MOLECULAR structure ,NUCLEAR magnetic resonance spectroscopy ,ORGANIC compounds ,RESEARCH funding ,DESCRIPTIVE statistics - Abstract
Chaetospirolactone (
1 ), a novel spiro-lactone bearing a rare 1-oxaspiro [4.4] non-7-ene-2,6-dione skeleton, and orsellide F (2 ), together with six known compounds (3-8 ), were isolated from an endophytic fungusChaetomium sp. NF00754. Their structures were determined by interpretation of spectroscopic data. The absolute configurations of1 and2 were established by analysis of single X-ray crystallographic data and CD spectra. Compounds3 ,4, and6 showed moderate acetylcholinesterase inhibitory activity with IC50 values of 7.34, 5.19, and 7.67 μM, respectively. [ABSTRACT FROM AUTHOR]- Published
- 2018
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