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Measurements in the stray radiation field from a proton therapy pencil beam at energies 70 and 146 MeV were performed using microdosimetric tissueequivalent proportional counters (TEPCs). The detector volumes were filled with a propane-based tissue-equivalent gas at low pressure simulating a mean chord length of 2 mmin tissue. Investigations were performed with and without a beam range shifter, and with different air gaps between the range shifter and a solid water phantom. The absorbed dose, the dose-mean lineal energy, and the dose equivalent were determined for different detector positions using the variance-covariance method. The influence from beam energy, detector- and range-shifter positions on absorbed dose, LET, and dose equivalent were investigated. Monte Carlo simulations of the fluence, detector response, and absorbed dose contribution from different particles were performed with MCNP 6.2. The simulated dose response for protons, neutrons, and photons were compared with, and showed good agreement with, previously published experimental data. The simulations also showed that the TEPC absorbed dose agrees well with the ambient absorbed dose for neutron energies above 20 MeV. The results illustrate that changes in both dose and LET variations in the stray radiation field can be identified from TEPC measurements using the variance-covariance method. The results are in line with the changes seen in the simulated relative dose contributions from different particles associated with different proton energies and range-shifter settings. It is shown that the proton contribution scattered directly from the range shifter dominates in some situations, and although the LET of the radiation is decreased, the ambient dose equivalent is increased up to a factor of 3. [ABSTRACT FROM AUTHOR]

Radiation-induced bone diseases were frequently reported in radiotherapy patients. To study the diseases, microdosimeters were constructed with walls of A150-A150, A150-B100, B100-A150 and B100-B100 interfaces. Monte Carlo simulations of these microdosimeters were performed to determine the lineal energy spectra of an interface site at different depths in water for 230 MeV protons. Comparing these spectra with data of ICRU tissue and bone walls, better agreements were found at shallow depths for protons and delta-rays than deep depths for nuclear interactions. [ABSTRACT FROM AUTHOR]

The increase in the number of therapeutic proton and ion beam centres worldwide has prompted renewed interest in measuring and simulating microdosimetric spectra in order to help understand the complexity underlying the Relative Biological Effectiveness (RBE) of these treatment modalities. In this context we have studied the capability of the Geant4 toolkit to simulate microdosimetric spectra measured with a Tissue Equivalent Proportional Counter (TEPC) in a clinical carbon ion beam. The simulated spectra were compared with published experimental data obtained along the depth dose curve of a 194 MeV/u carbon beam at the GSI, Darmstadt (Gerlach et al., 2002). The initial beam energy and energy spread employed in the simulation were tuned to match the calculated and measured depth dose distributions. A good agreement was found at all depths after a shift of 4.025 mm was taken into account with agreement for the microdosimetric derived RBE values to within 0.4% and 11.9% for depths 40 and 66 mm in PMMA (Perspex). This work demonstrates that the Geant4 toolkit can accurately reproduce experimental microdosimetric data and can thus be used for independent calculation of lineal energy spectra from which RBE estimates can be derived using the equation of Pihet et al. (1990). The work highlights the difficulty in using experimental work to benchmark Monte Carlo simulations and the need for detailed descriptions of experimental setups used. [ABSTRACT FROM AUTHOR]

Abstract: In the past few years, miniaturized tissue-equivalent gas detectors (mini TEPCs) have been developed for application of microdosimetry in radiotherapy. These mini-TEPCs are characterised by millimetric dimensions. They are equipped neither with an internal calibration source nor with electric field tubes, which would properly define the sensitive volume hence the simulated site size. In spite of these lacks, mini TEPCs working in gas flow conditions have proven to be precise and reliable detectors. However, for future therapeutic plans including microdosimetric data, consistency between experimental and calculated data is important. Existing general-purpose Monte Carlo codes have proven to be very useful to calculate the energy deposition due to ionization in macroscopic targets, even in various complex radiation fields. However, theoretical models implemented in these codes for simulating electron transport and straggling are valid only for energies above a few keV. This restricts their applicability for simulating radiation transport at a micrometric level, where low-energy electrons play a dominant role. In this work, we calculate frequency distributions of deposited energy in a mini TEPC (with sizes equivalent to 1 and 2 μm) due to photons using the Monte Carlo code FLUKA. Comparisons between simulated and experimental data show a rather good agreement. Differences due to different FLUKA settings are discussed. [ABSTRACT FROM AUTHOR]

Abstract: Monte Carlo simulations of heavy ion interactions using the Geant4 toolkit were compared with measurements of energy deposition in a spherical tissue-equivalent proportional counter (TEPC). A spherical cavity with a physical diameter of 12.7mm was filled with propane-based tissue-equivalent gas surrounded by a wall of A-150 tissue-equivalent plastic that was 2.54mm to thick. Measurements and Monte Carlo simulations were used to record the energy deposition and the trajectory of the incident particle on an event-by-event basis for ions ranging in atomic number from 2 (4He) to 26 (56Fe) and in energy from 200MeV/nucleon to 1000MeV/nucleon. In the simulations, tracking of secondary electrons was terminated when the range of an electron was below a specified threshold. The effects of range cuts for electrons at 0.5μm, 1μm, 10μm, and 100μm were evaluated. To simulate an energy deposition influenced by large numbers of low energy electrons with large transverse momentum, it was necessary to track electrons down to range cuts of 10μm or less. The Geant4 simulated data closely matched the measured data acquired using a TEPC for incident particles traversing the center of the detector as well as near the gas-wall interface. Values of frequency mean lineal energy and dose mean lineal energy were within 8% of the measured data. The production of secondary particles in the aluminum vacuum chamber had no effect on the response of the TEPC for 56Fe at 1000MeV/nucleon. The results of this study confirm that Geant4 can simulate patterns of energy deposition for existing microdosimeters and is valuable for improving the design of a new generation of detectors used for space dosimetry and for characterizing particle beams used in hadron radiotherapy. [Copyright &y& Elsevier]

A comparison of two types of dose equivalent meters, a recombination chamber REM-2 and a tissue-equivalent proportional counter (TEPC) Homburg Area Neutron DosImeter (HANDI), were carried out at the CERN-EC high-energy reference field facility, CERF, in October 2001. Here, the mixed high-energy radiation field in commercial flight altitudes can be simulated with dose rates up to 2 orders of magnitude higher. The total absorbed dose and the dose equivalent have been measured at different radiation field intensities. Of particular interest for measuring in the CERF field is the assessment of the low LET-component, i.e. the γ and muon components of the field, which are not taken into account by existing Monte Carlo simulations modeling the radiation field. The new results for the estimation of the low LET-component are compared with previous ones delivered by REM-2 at CERF. The results show good agreement between the REM-2 chamber and the HANDI. [Copyright &y& Elsevier]

Cosmic ray neutrons are produced by the interaction of primary cosmic rays with the air molecules present in the atmosphere. At the ground level, these secondary neutrons are one of the important contributors of natural cosmic ray radiation background dose. With two major peaks around 1 MeV and 100 MeV, the neutron energies can extend up to 10 GeV. At the ground level, considerable presence of thermal neutrons can also be observed due to collisions and moderation of fast neutrons with the soil and other surrounding materials. A study on the evaluation of cosmic ray neutron spectra, and the resulting ambient dose equivalents was carried out at High Altitude Research Laboratory, Gulmarg, India (altitude 2650 m, N34.0484°, E74.3805°) considering the enhanced contribution of cosmic ray background in the region. Extended energy Bonner Sphere Spectrometer (BSS) was used for the continuous measurement of cosmic ray neutrons during the period of October 2018 to June 2019. Neutron spectra and ambient dose equivalents were unfolded from the BSS counts with the Monte Carlo generated response matrix and the FRUIT unfolding code. Along with Bonner sphere spectrometer, Tissue Equivalent Proportional Counter (TEPC) was also used for a limited period for independent measurement of cosmic ray dose equivalents and Linear Energy Transfer (LET) distribution. For comparison, neutron spectra and dose equivalent rates were also calculated using Monte Carlo code FLUKA and EXPACS software program. The ambient dose equivalent rates were found to vary in the range of 24–34 nSv. h−1 during the entire observation period of 9 months. No considerable seasonal variations were observed during the course of the study. Dose equivalent rates, estimated by the TEPC were slightly higher than the neutron dose equivalent rates measured by BSS. Experimentally measured values match reasonably well with theoretically simulated results. • Neutron spectra of cosmic rays. • Ambient dose equivalent H*(10). • Microdosimetric spectra. • Response matrix calculation using Monte Carlo code. • Unfolding of neutron spectra. [ABSTRACT FROM AUTHOR]

To study the agreement between proton microdosimetric distributions measured with a silicon-based cylindrical microdosimeter and a previously published analytical microdosimetric model based on Geant4-DNA in-water Monte Carlo simulations for low energy proton beams. Distributions for lineal energy (y) are measured for four proton monoenergetic beams with nominal energies from 2.0 MeV to 4.5 MeV, with a tissue equivalent proportional counter (TEPC) and a silicon-based microdosimeter. The actual energy for protons traversing the silicon-based microdosimeter is simulated with SRIM. Monoenergetic beams with these energies are simulated with Geant4-DNA code by simulating a water cylinder site of dimensions equal to those of the microdosimeter. The microdosimeter response is calibrated by using the distribution peaks obtained from the TEPC. Analytical calculations for y ‾ F and y ‾ D using our methodology based on spherical sites are also performed choosing the equivalent sphere to be checked against experimental results. Distributions for y at silicon are converted into tissue equivalent and compared to the Geant4-DNA simulated, yielding maximum deviations of 1.03% for y ‾ F and 1.17% for y ‾ D. Our analytical method generates maximum deviations of 1.29% and 3.33%, respectively, with respect to experimental results. Simulations in Geant4-DNA with ideal cylindrical sites in liquid water produce similar results to the measurements in an actual silicon-based cylindrical microdosimeter properly calibrated. The found agreement suggests the possibility to experimentally verify the calculated clinical y ‾ D with our analytical method. • Validation of analytical microdosimetric models for protons of low energy. • Silicon-based microdosimeter is calibrated and employed for experimental data. • Distributions and averages of lineal energy are compared. • We found agreement among experiments, Geant4-DNA and analytical results. [ABSTRACT FROM AUTHOR]