1. Association of history of adverse childhood experiences with irritable bowel syndrome (IBS) in individuals with mood disorders.
- Author
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Rosenblat JD, Mansur RB, Brietzke E, Kennedy SH, Carvalho AF, Lee Y, Subramaniapillai M, Muzina DJ, Dale R, Tamura JK, Lui LMW, Park C, Phan L, Tuineag RM, and McIntyre RS
- Subjects
- Adult, Bipolar Disorder diagnosis, Bipolar Disorder psychology, Child, Cross-Sectional Studies, Depressive Disorder, Major diagnosis, Depressive Disorder, Major psychology, Female, Humans, Male, Middle Aged, Prevalence, Retrospective Studies, Sex Offenses psychology, Sex Offenses trends, Adverse Childhood Experiences trends, Irritable Bowel Syndrome diagnosis, Irritable Bowel Syndrome psychology, Mood Disorders diagnosis, Mood Disorders psychology
- Abstract
The objective of the current study was to assess the association between adverse childhood experiences (ACEs) and irritable bowel syndrome (IBS) in mood disorder patients. Self-report data from the International Mood Disorders Collaborative Project were cross-sectionally analyzed to compare rates of IBS in participants with confirmed diagnoses of major depressive disorder (MDD; n = 279) or bipolar disorder (BD; n = 219). Data was sub-grouped and compared based on history of ACEs. In total, 69 of the 498 participants reported a diagnosis of IBS (13.8%). BD was associated with significantly elevated rates of IBS compared to MDD (18.5% versus 10.1% respectively). After adjusting for age and sex, history of childhood sexual abuse was associated with increased rates of IBS in mood disorder participants [adjusted odds ratio (aOR) = 1.95]. In the MDD subgroup, ACEs (all categories and individual categories) were not associated with increased rates of IBS. In the BD subgroup, history of childhood sexual abuse was associated with significantly increased rates of IBS (38% versus 14%; aOR = 3.7). In summary, BD was associated with a higher prevalence of IBS compared to MDD. Additionally, history of sexual abuse was associated with an increased prevalence of IBS in BD, but not in MDD., (Copyright © 2020. Published by Elsevier B.V.)
- Published
- 2020
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