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1. Effect of potentiated antibodies to morphine on behavioral reactions in rats with morphine dependence.

Author

Vorob'eva TM, Berchenko OG, Geiko VV, Kolyadko SP, Bevzyuk DA, Pan IR, and Epstein OI

Subjects
Animals, Brain drug effects, Brain metabolism, Male, Morphine immunology, Rats, Self Stimulation drug effects, Antibodies pharmacology, Behavior, Animal drug effects, Morphine antagonists & inhibitors, Morphine Dependence
Abstract

We studied the effect of potentiated antibodies to morphine (10(-100) wt %) on self-stimulation of the lateral hypothalamus and behavioral reactions reflecting the severity of withdrawal syndrome in rats with morphine dependence. Repeated treatment with potentiated antibodies to morphine increased the rate of self-stimulation, suppressed active avoidance response, promoted freezing behavior after acoustic stimulation, and decreased tail-flick latency in rats after morphine withdrawal. Distilled water did not produce these changes.

Published
2003
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