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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2008.07.004 Byline: Tamara B. Horwich (a), Adrian F. Hernandez (b), David Dai (b), Clyde W. Yancy (c), Gregg C. Fonarow (a) Abstract: In chronic heart failure (HF), lower total cholesterol (TC) levels have been associated with increased mortality. However, the relationship between lipid levels and outcomes in acute HF has not been studied. This study investigates the relationship between cholesterol levels and in-hospital mortality in patients hospitalized with acute HF. Author Affiliation: (a) Ahmanson-UCLA Cardiomyopathy Center, University of California, Los Angeles, CA (b) Duke Clinical Research Institute, Durham, NC (c) Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX Article History: Received 22 May 2008; Accepted 5 July 2008 Article Note: (footnote) This study was funded by the American Heart Association (Dallas, TX) with support from an unrestricted educational grant from GlaxoSmithKline (Philadelphia, PA). Dr Horwich is supported by the National Institutes of Health 1K23HL085097 (Bethesda, MD). Dr Hernandez is a recipient of an American Heart Association Pharmaceutical Roundtable grant (0675060N) and a research support from GlaxoSmithKline. Dr Horwich has no funding/support to disclose; Dr Dai is an employee of Duke Clinical Research Institute (Durham, NC); Drs Yancy and Fonarow engage in research and are consultants in GlaxoSmithKline and received honorarium from the same company; Dr Fonarow is the chair of the Get With the Guidelines Steering Committee, and holds the Eliot Corday Chair in Cardiovascular Medicine and Science.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2008.04.030 Byline: Christopher M. O'Connor (a), William T. Abraham (b), Nancy M. Albert (c), Robert Clare (d), Wendy Gattis Stough (e)(f), Mihai Gheorghiade (g), Barry H. Greenberg (h), Clyde W. Yancy (i), James B. Young (c), Gregg C. Fonarow (j) Abstract: Patients with heart failure (HF) are at high risk for mortality and rehospitalization in the early period after hospital discharge. We developed clinical models predictive of short-term clinical outcomes in a broad patient population discharged after hospitalization for HF. Author Affiliation: (a) Duke University Medical Center/Duke Clinical Research Institute, Durham, NC (b) The Ohio State University, Columbus, OH (c) George M. and Linda H. Kaufman Center for Heart Failure, Cleveland Clinic Foundation, Cleveland, OH (d) Duke Clinical Research Institute, Durham, NC (e) Duke University Medical Center, Durham, NC (f) Department of Clinical Research, Campbell University School of Pharmacy, Research Triangle Park, NC (g) Northwestern University, Chicago, IL (h) University of California San Diego-Hillcrest Medical Center, San Diego, CA (i) Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, TX (j) University of California-Los Angeles Medical Center, Los Angeles, CA Article History: Received 19 November 2007; Accepted 16 April 2008 Article Note: (footnote) The OPTIMIZE-HF registry is registered: http://www.clinicaltrials.gov, study number NCT00344513., The OPTIMIZE-HF registry was supported by GlaxoSmithKline (Philadelphia, PA).

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2008.04.003 Byline: Jason Swindle (a), Thomas E. Burroughs (a), Mark A. Schnitzler (a), Paul J. Hauptman (a)(b) Abstract: The use of implantable cardiac devices in the management of heart failure has increased, but patient selection and inhospital outcomes in clinical practice have not been critically explored. Therefore, we evaluated the inhospital mortality and costs associated with patients with heart failure who received an implantable cardioverter defibrillator, cardiac resynchronization device, or device lead. Author Affiliation: (a) Center for Outcomes Research, Saint Louis University School of Medicine, St Louis, MO (b) Division of Cardiology, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO Article History: Received 7 January 2008; Accepted 3 April 2008 Article Note: (footnote) The study is supported in part by National Institutes of Health RO1-AG021515 (Dr P Hauptman)., Dr Hauptman: Grant support from the National Institutes of Health; local site coinvestigator on the SCD-HeFT trial. Mr Swindle: No relevant financial relationships. Dr Burroughs: No relevant financial relationships. Dr Schnitzler: No relevant financial relationships.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2007.11.030 Byline: Jean-Michel Tartiere (a), Jean-Yves Tabet (b), Damien Logeart (b), Lamia Tartiere-Kesri (b), Florence Beauvais (b), Christophe Chavelas (b), Alain Cohen Solal (b) Abstract: The left ventricular (LV) developed pressure is a marker of contractility, associated with a poor prognosis during systolic heart failure. The maximal first derivative or slope of the radial pulse wave (Rad dP/dt) has been proposed as a marker of LV systolic function. This study sought to assess the prognostic value of the baseline dP/dt of the radial pulse in patients with heart failure. Author Affiliation: (a) Department of Physiology, Lariboisiere Hospital, Assistance Publique, Paris, France (b) Department of Cardiology, Lariboisiere Hospital, Assistance Publique, Paris, France Article History: Received 3 July 2007; Accepted 12 November 2007 Article Note: (footnote) This study was supported by a grant from the French Society of Cardiology.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2007.04.002 Byline: Morten Schou (a), Finn Gustafsson (b), Pernille Corell (a), Caroline N. Kistorp (a), Andreas Kjaer (c)(d), Per R. Hildebrandt (e) Abstract: N-terminal pro-brain natriuretic peptide (NT-proBNP) carries prognostic information in patients with chronic heart failure and predicts risk for mortality and cardiovascular events. It is unknown whether NT-proBNP predicts risk for hospitalization for any cause. Furthermore, a clinically useful algorithm for risk stratification based on NT-proBNP as a continuous variable has not yet been described. We therefore evaluated NT-proBNP as a risk marker for mortality and hospitalization and developed a simple algorithm for risk stratification based on NT-proBNP as a continuous variable. Author Affiliation: (a) Department of Cardiology and Endocrinology, Clinic E, Frederiksberg University Hospital, Frederiksberg, Denmark (b) Department of Cardiology, The Heart Centre, Rigshospitalet University Hospital, Copenhagen, Denmark (c) Department of Clinical Physiology and Nuclear Medicine, The PET Centre, Rigshospitalet University Hospital, Copenhagen, Denmark (d) Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark (e) Department of Cardiology, Roskilde University Hospital, Roskilde, Denmark Article History: Received 17 January 2007; Accepted 1 April 2007 Article Note: (footnote) Dr Hildebrandt has received honoraria for lectures on N-terminal pro-brain natriuretic peptide from Roche Diagnostics, Basel, Switzerland., Dr Schou is supported by research grant 200207135A-321 from the Copenhagen Hospital Corporation, Copenhagen, Denmark.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2007.03.043 Byline: Wei Jiang (a)(b), Maragatha Kuchibhatla (c), Greg L. Clary (d), Michael S. Cuffe (a), Eric J. Christopher (a)(b), Jude D. Alexander (e), Robert M. Califf (a), Ranga R. Krishnan (b), Christopher M. O'Connor (a) Abstract: Depression is prevalent in patients with heart failure (HF) and is associated with short-term poor prognosis. However, the long-term effect of depression and the use of self-administered depression evaluation on HF prognosis remained unknown. The study sought to assess the association of depressive symptoms and long-term mortality of patients with HF and to explore the prognostic predictability of the Beck Depression Inventory (BDI) scale for patients with HF. Author Affiliation: (a) Department of Medicine, Duke University Medical Center, Durham, NC (b) Department of Psychiatry & Behavioral Sciences, Duke University Medical Center, Durham, NC (c) Aging Center, Duke University Medical Center, Durham, NC (d) Grace Hospital, Morganton, NC (e) Medicine/Psychiatry Services, Shady Grove Adventist Hospital, Rockville, MD Article History: Received 6 November 2006; Accepted 23 March 2007 Article Note: (footnote) The study was supported in part by National Institutes of Mental Health grants R01MH51191 and R01MH63211-Minority Supplement Award (WJ), and the APIRE/Merck & Co. Early Academic Career Research Award, 2004 (WJ).

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2007.03.016 Byline: Francois Alla (e), Ahmad Y. Al-Hindi (a)(b), Craig R. Lee (c), Todd A. Schwartz (d), J. Herbert Patterson (c), Kirkwood F. Adams (a)(b) Abstract: Previous studies indicate a survival advantage for women over men with chronic heart failure associated with reduced or preserved ejection fraction. Whether women with chronic heart failure are at less risk for hospitalization for worsening heart failure has not been well investigated. Author Affiliation: (a) Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC (b) Department of Radiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC (c) School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC (d) Department of Biostatistics, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC (e) Department of Epidemiology, University Hospital of Nancy, Nancy, France Article History: Received 26 July 2006; Accepted 7 March 2007

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.05.018 Byline: Eldrin F. Lewis (a), Anne S. Hellkamp (b), Marc A. Pfeffer (a), Arnold J. Greenspon (c), Christian Machado (d), Steven Singh (e), Eleanor Schron (f), Kerry L. Lee (b), Gervasio A. Lamas (g) Abstract: Patient and physician preferences as well as cost favor an increasingly higher threshold for hospital admission for heart failure (HF) treatment. This trend risks masking the severity and prevalence of HF as hospitalization for HF may decrease. Author Affiliation: (a) Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (b) Duke Clinical Research Center and Duke Medical School, Durham, NC (c) Thomas Jefferson University Hospital, Philadelphia, PA (d) Providence Hospital, Southfield, MI (e) Veterans Affairs Medical Center, Washington, DC (f) Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD (g) Mount Sinai Medical Center-Miami Heart Institute, Miami Beach, FL Article History: Received 26 October 2004; Accepted 2 May 2005 Article Note: (footnote) This study was supported by grants U01 HL 49804 (Dr Lamas), U01 HL53973 (Dr Lee), and 1 F32 HL71449-01 (Dr Lewis) from the National Heart, Lung, and Blood Institute of the National Institutes of Health, Bethesda, Md. Medtronic Inc, Guidant Corp, and St Jude Medical donated additional support for study meetings and ancillary studies.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.04.022 Byline: Kathy A. Hebert (a), Ronald L. Horswell (b), Sydney Dy (c), Ira J. Key (d), Michael K. Butler (d), Frederick P. Cerise (e), Lee M. Arcement (f) Abstract: Heart failure (HF) produces significant morbidity and mortality. Although HF disease management (HFDM) programs have been shown to decrease this morbidity, there is still a paucity of data on their effect on mortality. The objective of this study was to determine whether participation in an HFDM program would reduce mortality in an indigent population from rural Louisiana. Author Affiliation: (a) Leonard J. Chabert Medical Center, Houma, LA (b) Department of Public Health and Preventive Medicine, Louisiana State University Health Sciences Center, New Orleans, LA (c) Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD (d) Health Care Services Division, Louisiana State University Health Sciences Center, New Orleans, LA (e) Earl K. Long Medical Center, Baton Rouge, LA (f) Ochsner Medical Foundation, New Orleans, LA Article History: Received 1 October 2004; Accepted 26 April 2005 Article Note: (footnote) This study was supported in part by grants from the Agency for Healthcare Quality and Research and the Baton Rouge Area Foundation.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.03.066 Byline: Ali Ahmed (a)(b), Wilbert S. Aronow (c), Jerome L. Fleg (d) Abstract: The association between higher New York Heart Association (NYHA) class and outcomes in patients with heart failure and preserved systolic function is not well known. Author Affiliation: (a) Division of Gerontology and Geriatric Medicine, Departments of Medicine and Epidemiology, University of Alabama at Birmingham, Birmingham, AL (b) Section of Geriatrics, Veterans Affairs Medical Center, Birmingham, AL (c) Cardiology Division, Department of Medicine, New York Medical College, Valhalla, NY (d) National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD Article History: Received 1 November 2004; Accepted 26 March 2005 Article Note: (footnote) Ahmed is supported by a National Institutes of Health Mentored Patient-Oriented Research Career Development Award 1-K23-AG19211-01.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.03.009 Byline: Tobias T. Lee, Jersey Chen, David J. Cohen, Lana Tsao Abstract: The association between low blood pressure and prognosis in the general population has been controversial, with some reports suggesting an increased mortality for patients with the lowest blood pressures. Whereas many standard heart failure therapies decrease blood pressure, the relationship between mortality and blood pressure in patients with heart failure has not been previously evaluated. Author Affiliation: Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA Article History: Received 6 October 2004; Accepted 1 March 2005

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.01.049 Byline: Sonia Ralli, Tamara B. Horwich, Gregg C. Fonarow Abstract: Anemia has been associated with worse symptoms and increased mortality in patients with advanced HF. The association between anemia and biomarkers of increased HF risk is unknown. This study aimed to evaluate the relationship between hemoglobin (Hb), cardiac troponin I (cTnI), B-type natriuretic peptide (BNP), and mortality in patients with advanced heart failure (HF). Author Affiliation: UCLA Division of Cardiology, Ahmanson-UCLA Cardiomyopathy Center, Los Angeles, CA Article History: Received 30 June 2004; Accepted 10 January 2005 Article Note: (footnote) This research was supported by the Ahmanson Foundation, Los Angeles, Calif. Doctor Horwich was funded by NIH training grant 401357JI30608. Doctor Fonarow holds the Eliot Corday Chair in Cardiovascular Medicine and Science.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.02.036 Byline: John S. Rumsfeld (a)(b), Philip G. Jones (c)(d), Mary A. Whooley (e)(f), Mark D. Sullivan (g), Bertram Pitt (h), William S. Weintraub (i), John A. Spertus (c)(d) Abstract: To evaluate whether depressive symptoms are independently predictive of mortality and hospitalization among patients with acute myocardial infarction (AMI) complicated by heart failure. Author Affiliation: (a) Section of Cardiology, Denver VA Medical Center, Denver, Colo (b) Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colo (c) Cardiovascular Outcomes Research, Mid-America Heart Institute, Kansas City, Mo (d) Department of Medicine, University of Missouri-Kansas City, Kansas City, Mo (e) Section of General Internal Medicine, San Francisco VA Medical Center, San Francisco, Calif (f) Department of Medicine, University of California, San Francisco, San Francisco, Calif (g) Department of Psychiatry, University of Washington School of Medicine, Seattle, Wash (h) Division of Cardiology, University of Michigan School of Medicine, Ann Arbor, Mich (i) Emory Center for Outcomes Research, Emory University School of Medicine, Atlanta, Ga Article History: Received 23 December 2004; Accepted 21 February 2005 Article Note: (footnote) [star] Funding for this study was provided by Pharmacia Corporation. Dr. Rumsfeld was supported by a VA Health Services Research Advanced Career Development Award (ARCD 98341-2).

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2004.08.039 Byline: JoAnn Lindenfeld Abstract: In patients with chronic kidney disease, the adverse cardiovascular effects of anemia have been well established. New data are emerging to suggest anemia may represent an important treatable cause of cardiac morbidity and mortality in patients with heart failure. To improve the understanding of the problem of anemia in heart failure, it is important to assess the factors that influence the prevalence of anemia and to assess the consistency of the association of anemia and mortality in various populations of patients with heart failure. Author Affiliation: Cardiac Transplantation Program and the Center for Women's Health Research, University of Colorado Health Sciences Center, Denver, Colo Article History: Received 25 May 2004; Accepted 26 August 2004 Article Note: (footnote) Support for this literature review and preparation of the manuscript provided by Amgen Inc.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2004.10.002 Byline: Christian Torp-Pedersen (a), Philip A. Poole-Wilson (b), Karl Swedberg (c), John G.F. Cleland (d), Andrea Di Lenarda (e), Peter Hanrath (f), Michel Komajda (g), Beatrix Lutiger (h), Marco Metra (j), Willem J. Remme (k), Armin Scherhag (h)(i), Allan Skene (l) Abstract: [beta]-Blockers with different receptor bindings reduce mortality in patients with chronic heart failure. We compared the effects of the [beta].sub.1-blocker metoprolol tartrate and the [beta].sub.1-, [beta].sub.2-, and [alpha].sub.1-blocker carvedilol. Author Affiliation: (a) Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark (b) National Heart and Lung Institute, Imperial College London, United Kingdom (c) Department of Medicine, Sahlgrenska University Hospital/Astra, Goteborg, Sweden (d) Department of Cardiology, University of Hull, Kingston upon Hull, United Kingdom (e) Department of Cardiology, Ospedale di Cattinara, Trieste, Italy (f) Medizinische Klinik 1, University Hospital, Aachen, Germany (g) Department of Cardiology, La Pitie-Salpetriere Hospital, Paris, France (h) F Hoffmann-La Roche, Basel, Switzerland (i) I. Medical Clinic, University Hospital Mannheim, University of Heidelberg, Germany (j) Cattedra di Cardiologia, Universita di Brescia, Italy (k) Sticares Cardiovascular Research Foundation, Rhoon, The Netherlands (l) Nottingham Clinical Research Group (NCRG), Nottingham, UK Article History: Received 9 May 2004; Accepted 9 October 2004

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2008.12.010 Byline: Quynh A. Truong (a), Christopher P. Cannon (b), Neil A. Zakai (c), Ian S. Rogers (a), Robert P. Giugliano (b), Stephen D. Wiviott (b), Carolyn H. McCabe (b), David A. Morrow (b), Eugene Braunwald (b) Abstract: TIMI (Thrombolysis in Myocardial Infarction) Risk Index (TRI) is a simple bedside score that predicts 30-day mortality in patients with ST-elevation myocardial infarction (MI). We sought to evaluate whether TRI was predictive of long-term mortality and clinical events. Author Affiliation: (a) Division of Cardiology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (b) TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (c) Departments of Medicine and Pathology, University of Vermont College of Medicine, Burlington, VT Article History: Received 5 November 2008; Accepted 10 December 2008 Article Note: (footnote) The TIMI 2 trial was supported by research contracts from the National Heart, Lung, and Blood Institute (Bethesda, MD). Drs Truong and Rogers received support from National Institutes of Health (Bethesda, MD) grant L30HL093896 and T32HL076136.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.10.008 Byline: Shervin Eshaghian (a), Tamara B. Horwich (b), Gregg C. Fonarow (b) Abstract: In diabetes, poor glycemic control, as indexed by hemoglobin A1.sub.c (HbA.sub.1c), is associated with increased risk of cardiovascular events and new-onset heart failure (HF). However, in patients with diabetes and HF, the relationship between glucose control and survival has not been investigated. Our study aimed to evaluate the relationship between HbA.sub.1c levels and mortality in patients with diabetes and advanced systolic HF. Author Affiliation: (a) Cedars Sinai Medical Center, Los Angeles, CA (b) Ahmanson-UCLA Cardiomyopathy Center, Los Angeles, CA Article History: Received 17 June 2005; Accepted 16 October 2005 Article Note: (footnote) The research was supported by the Ahmanson Foundation, Los Angeles, CA. Dr Horwich was funded by NIH training grant 401357JI30608. Dr Fonarow holds the Eliot Corday Chair in Cardiovascular Medicine and Science.