1. The Impact of Diffusion Tensor Imaging Fiber Tracking of the Corticospinal Tract Based on Navigated Transcranial Magnetic Stimulation on Surgery of Motor-Eloquent Brain Lesions.
- Author
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Raffa G, Conti A, Scibilia A, Cardali SM, Esposito F, Angileri FF, La Torre D, Sindorio C, Abbritti RV, Germanò A, and Tomasello F
- Subjects
- Adult, Aged, Brain Mapping methods, Brain Neoplasms surgery, Case-Control Studies, Craniotomy methods, Female, Humans, Karnofsky Performance Status, Male, Middle Aged, Motor Cortex surgery, Pyramidal Tracts surgery, Retrospective Studies, Brain Neoplasms diagnostic imaging, Diffusion Tensor Imaging methods, Intraoperative Neurophysiological Monitoring methods, Motor Cortex diagnostic imaging, Pyramidal Tracts diagnostic imaging, Transcranial Magnetic Stimulation methods
- Abstract
Background: Navigated transcranial magnetic stimulation (nTMS) enables preoperative mapping of the motor cortex (M1). The combination of nTMS with diffusion tensor imaging fiber tracking (DTI-FT) of the corticospinal tract (CST) has been described; however, its impact on surgery of motor-eloquent lesions has not been addressed., Objective: To analyze the impact of nTMS-based mapping on surgery of motor-eloquent lesions., Methods: In this retrospective case-control study, we reviewed the data of patients operated for suspected motor-eloquent lesions between 2012 and 2015. The patients underwent nTMS mapping of M1 and, from 2014, nTMS-based DTI-FT of the CST. The impact on the preoperative risk/benefit analysis, surgical strategy, craniotomy size, extent of resection (EOR), and outcome were compared with a control group., Results: We included 35 patients who underwent nTMS mapping of M1 (group A), 35 patients who also underwent nTMS-based DTI-FT of the CST (group B), and a control group composed of 35 patients treated without nTMS (group C). The patients in groups A and B received smaller craniotomies (P = .01; P = .001), had less postoperative seizures (P = .02), and a better postoperative motor performance (P = .04) and Karnofsky Performance Status (P = .009) than the controls. Group B exhibited an improved risk/benefit analysis (P = .006), an increased EOR of nTMS-negative lesions in absence of preoperative motor deficits (P = .01), and less motor and Karnofsky Performance Status worsening in case of preoperative motor deficits (P = .02, P = .03) than group A., Conclusion: nTMS-based mapping enables a tailored surgical approach for motor-eloquent lesions. It may improve the risk/benefit analysis, EOR and outcome, particularly when nTMS-based DTI-FT is performed. more...
- Published
- 2018
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