7 results on '"Jansen, Robin W."'
Search Results
2. Advances in Imaging in Ocular Oncology: A Radiologist’s Perspective
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de Graaf, Pim, Jansen, Robin W., Galluzzi, Paolo, de Jong, Marcus C., Chawla, Bhavna V., editor, and Aronow, Mary E., editor
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- 2022
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3. The Prediction of Biological Features Using Magnetic Resonance Imaging in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
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van der Hulst, Hedda J., Jansen, Robin W., Vens, Conchita, Bos, Paula, Schats, Winnie, de Jong, Marcus C., Martens, Roland M., Bodalal, Zuhir, Beets-Tan, Regina G. H., van den Brekel, Michiel W. M., de Graaf, Pim, and Castelijns, Jonas A.
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DIGITAL image processing , *META-analysis , *GENETICS , *SYSTEMATIC reviews , *MAGNETIC resonance imaging , *HEAD & neck cancer , *PAPILLOMAVIRUS diseases , *DESCRIPTIVE statistics , *TUMOR markers , *PREDICTION models , *TRANSCRIPTION factors , *SQUAMOUS cell carcinoma , *PERFUSION , *DISEASE complications - Abstract
Simple Summary: This systematic review evaluates the potential of magnetic resonance imaging (MRI) to predict tumor biology in primary squamous cell carcinoma of the head and neck (HNSCC). Fifty-eight articles were analyzed, examining the relationship between MRI parameters and biological features. Most studies focused on HPV status associations, revealing that HPV-positive tumors consistently exhibited lower diffusion-weighted metrics. Moreover, lower diffusion values were also with a high Ki-67 proliferation index, indicating high cellularity. Several perfusion parameters describing the vascularity were significantly associated with HIF-1α. Analysis results of other biological factors (VEGF, EGFR, tumor cell count, p53, and MVD) were inconclusive. Larger datasets are needed to develop and validate radiomic-based prediction models, which already show promising results in capturing diverse tumor biology features. Overall, MRI holds potential for non-invasive and rapid tumor biology characterization, enhancing future clinical outcome predictions and personalized patient management for HNSCC. Magnetic resonance imaging (MRI) is an indispensable, routine technique that provides morphological and functional imaging sequences. MRI can potentially capture tumor biology and allow for longitudinal evaluation of head and neck squamous cell carcinoma (HNSCC). This systematic review and meta-analysis evaluates the ability of MRI to predict tumor biology in primary HNSCC. Studies were screened, selected, and assessed for quality using appropriate tools according to the PRISMA criteria. Fifty-eight articles were analyzed, examining the relationship between (functional) MRI parameters and biological features and genetics. Most studies focused on HPV status associations, revealing that HPV-positive tumors consistently exhibited lower ADCmean (SMD: 0.82; p < 0.001) and ADCminimum (SMD: 0.56; p < 0.001) values. On average, lower ADCmean values are associated with high Ki-67 levels, linking this diffusion restriction to high cellularity. Several perfusion parameters of the vascular compartment were significantly associated with HIF-1α. Analysis of other biological factors (VEGF, EGFR, tumor cell count, p53, and MVD) yielded inconclusive results. Larger datasets with homogenous acquisition are required to develop and test radiomic-based prediction models capable of capturing different aspects of the underlying tumor biology. Overall, our study shows that rapid and non-invasive characterization of tumor biology via MRI is feasible and could enhance clinical outcome predictions and personalized patient management for HNSCC. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Screening for pineal trilateral retinoblastoma revisited: a meta-analysis
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de Jong, Marcus C, Kors, Wijnanda A, Moll, Annette C, de Graaf, Pim, Castelijns, Jonas A, Jansen, Robin W, Gallie, Brenda, Soliman, Sameh E, Shaikh, Furqan, Dimaras, Helen, Kivelä, Tero T, HUS Head and Neck Center, Silmäklinikka, Department of Ophthalmology and Otorhinolaryngology, University of Helsinki, and Helsinki University Hospital Area
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endocrine system ,AGED 0-5 YEARS ,MRI-BASED ASSESSMENT ,PINEALOBLASTOMA ,screening ,CHILDREN ,lead time ,eye diseases ,retinoblastoma ,period at risk ,HIGH-DOSE CHEMOTHERAPY ,GLAND ,STEM-CELL RESCUE ,trilateral retinoblastoma ,INTRAARTERIAL ,3125 Otorhinolaryngology, ophthalmology ,LARGE POPULATION ,pineoblastoma ,MRI - Abstract
TOPIC: To determine the age up to which children are at risk of trilateral retinoblastoma (TRb) developing, whether its onset is linked to the age at which intraocular retinoblastomas develop, and the lead time from a detectable pineal TRb to symptoms.CLINICAL RELEVANCE: Approximately 45% of patients with retinoblastoma-those with a germline RB1 pathogenic variant-are at risk of pineal TRb developing. Early detection and treatment are essential for survival. Current evidence is unclear regarding the usefulness of screening for pineal TRb and, if useful, the age up to which screening should be continued.METHODS: We conducted a study according to the Meta-analysis of Observational Studies in Epidemiology guidelines for reporting meta-analyses of observational studies. We searched PubMed and Embase between January 1, 1966, and February 27, 2019, for published literature. We considered articles reporting patients with TRb with survival and follow-up data. Inclusion of articles was performed separately and independently by 2 authors, and 2 authors also independently extracted the relevant data. They resolved discrepancies by consensus.RESULTS: One hundred thirty-eight patients with pineal TRb were included. Of 22 asymptomatic patients, 21 (95%) were diagnosed before the age of 40 months (median, 16 months; interquartile range, 9-29 months). Age at diagnosis of pineal TRb in patients diagnosed with retinoblastoma at 6 months or younger versus older than 6 months were comparable (P = 0.44), suggesting independence between the ages at diagnosis of intraocular retinoblastoma and pineal TRb. The laterality of intraocular retinoblastoma and its treatment were not associated with the age at which pineal TRb was diagnosed. The lead time from asymptomatic to symptomatic pineal TRb was approximately 1 year. By performing a screening magnetic resonance imaging scan every 6 months after the diagnosis of heritable retinoblastoma (median age, 6 months) until 36 months of age, at least 311 and 776 scans would be required to detect 1 case of asymptomatic pineal TRb and to save a single life, respectively.CONCLUSIONS: Patients with retinoblastoma are at risk of pineal TRb developing for a shorter period than previously assumed, and the age at diagnosis of pineal TRb is independent of the age at diagnosis of retinoblastoma. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) level of evidence for these conclusions remains low.
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- 2020
5. Asynchronous pineoblastoma is more likely after early diagnosis of retinoblastoma: a meta‐analysis.
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de Jong, Marcus C., Shaikh, Furqan, Gallie, Brenda, Kors, Wijnanda A., Jansen, Robin W., Dommering, Charlotte, de Graaf, Pim, Moll, Annette C., Dimaras, Helen, Shroff, Manohar, Kivelä, Tero T., and Soliman, Sameh E.
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EARLY diagnosis ,RETINOBLASTOMA ,MEDICAL screening ,MAGNETIC resonance imaging - Abstract
Purpose: To determine the risk of patients with an early diagnosis of heritable retinoblastoma being diagnosed with TRb (or pineoblastoma) asynchronously in a later stage and its effect on screening. Methods: We updated the search (PubMed and Embase) for published literature as performed by our research group in 2014 and 2019. Trilateral retinoblastoma (TRb) patients were eligible for inclusion if identifiable as unique and the age at which TRb was diagnosed was available. The search yielded 97 new studies. Three new studies and eight new patients were included. Combined with 189 patients from the previous meta‐analysis, the database included 197 patients. The main outcome was the percentage of asynchronous TRb in patients diagnosed before and after preset age thresholds of 6 and 12 months of age at retinoblastoma diagnosis. Results: Seventy‐nine per cent of patients with pineoblastoma are diagnosed with retinoblastoma before the age of 12 months. However, baseline MRI screening at time of retinoblastoma diagnosis fails to detect the later diagnosed pineal TRb in 89% of patients. We modelled that an additional MRI performed at the age of 29 months picks up 53% of pineoblastomas in an asymptomatic phase. The detection rate increased to 72%, 87% and 92%, respectively, with 2, 3 and 4 additional MRIs. Conclusions: An MRI of the brain in heritable retinoblastoma before the age of 12 months misses most pineoblastomas, while retinoblastomas are diagnosed most often before the age of 12 months. Optimally timed additional MRI scans of the brain can increase the asymptomatic detection rate of pineoblastoma. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Full-width postlaminar optic nerve tumor invasion of retinoblastoma as risk-factor for leptomeningeal spread of retinoblastoma. A case report and review of the literature.
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de Jong, Marcus C., Van Der Valk, Paul, Jansen, Robin W., Abbink, Floor, Bosscha, Machteld, Castelijns, Jonas A., Moll, Annette C., and de Graaf, Pim
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OPTIC nerve ,LITERATURE reviews ,OPHTHALMIC artery ,CANCER invasiveness ,METASTASIS ,TUMORS - Abstract
We present a 6-year-old boy with unilateral retinoblastoma of the left eye. MRI showed an intraocular tumor that extended into the optic nerve beyond the lamina cribrosa. The affected eye was enucleated and the optic nerve resection margin proved to be free. Following protocol, this patient received six courses of adjuvant systemic chemotherapy. Unfortunately, after 5 months this patient returned with the leptomeningeal spread of the tumor and died quickly thereafter. Histopathologic analysis of the enucleated eye and distal optic nerve revealed that the postlaminar tumor cells occupied the entire width of the optic nerve, extending all the way up to the pia mater, whereas, more often the tumor invasion is restricted to the center of the optic nerve. This was also visible on the MR images where contrast enhancement occupied the entire nerve width. A resection margin with tumor cells is recognized as a risk factor for metastasis, but perhaps the proximity of tumor cells to the leptomeninges should also be judged with caution as a potential increased risk for metastatic spread. [ABSTRACT FROM AUTHOR]
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- 2020
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7. MR Imaging Features to Differentiate Retinoblastoma from Coats' Disease and Persistent Fetal Vasculature.
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Jansen, Robin W., de Bloeme, Christiaan M., Brisse, Hervé J., Galluzzi, Paolo, Cardoen, Liesbeth, Göricke, Sophia, Maeder, Philippe, Cassoux, Nathalie, Gauthier, Arnaud, Schlueter, Sabrina, Hadjistilianou, Theodora, Munier, Francis L., Castelijns, Jonas A., van der Valk, Paul, Moll, Annette C., de Jong, Marcus C., and de Graaf, Pim
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RETINAL disease diagnosis , *CYTOCHEMISTRY , *DIFFERENTIAL diagnosis , *EYE abnormalities , *MAGNETIC resonance imaging , *RETINOBLASTOMA , *TELANGIECTASIA , *RETROSPECTIVE studies , *DESCRIPTIVE statistics - Abstract
Simple Summary: Retinoblastoma is a rare cancer that develops in the retina of children. Accurate differentiation between retinoblastoma and conditions that show similarities with retinoblastoma (pseudoretinoblastoma or retinoblastoma mimickers) is vital for guiding treatment. The most common pseudoretinoblastoma conditions are Coats' disease and persistent fetal vasculature (PFV). In this study, we aimed to improve pretreatment differentiation between these diseases on MR imaging. We compared pre-treatment MR images of retinoblastoma, Coats' disease and PFV on 20 predefined MR imaging features. An assessment strategy was proposed incorporating MR imaging features that best differentiate retinoblastoma from pseudoretinoblastoma, including three newly identified MR imaging features. Retinoblastoma mimickers, or pseudoretinoblastoma, are conditions that show similarities with the pediatric cancer retinoblastoma. However, false-positive retinoblastoma diagnosis can cause mistreatment, while false-negative diagnosis can cause life-threatening treatment delay. The purpose of this study is to identify the MR imaging features that best differentiate between retinoblastoma and the most common pseudoretinoblastoma diagnoses: Coats' disease and persistent fetal vasculature (PFV). Here, six expert radiologists performed retrospective assessments (blinded for diagnosis) of MR images of patients with a final diagnosis based on histopathology or clinical follow-up. Associations between 20 predefined imaging features and diagnosis were assessed with exact tests corrected for multiple hypothesis testing. Sixty-six patients were included, of which 33 (50%) were retinoblastoma and 33 (50%) pseudoretinoblastoma patients. A larger eye size, vitreous seeding, and sharp-V-shaped retinal detachment were almost exclusively found in retinoblastoma (p < 0.001–0.022, specificity 93–97%). Features that were almost exclusively found in pseudoretinoblastoma included smaller eye size, ciliary/lens deformations, optic nerve atrophy, a central stalk between optic disc and lens, Y-shaped retinal detachment, and absence of calcifications (p < 0.001–0.022, specificity 91–100%). Additionally, three newly identified imaging features were exclusively present in pseudoretinoblastoma: intraretinal macrocysts (p < 0.001, 38% [9/24] in Coats' disease and 20% [2/10] in PFV), contrast enhancement outside the solid lesion (p < 0.001, 30% [7/23] in Coats' disease and 57% [4/7] in PFV), and enhancing subfoveal nodules (38% [9/24] in Coats' disease). An assessment strategy was proposed for MR imaging differentiation between retinoblastoma and pseudoretinoblastoma, including three newly identified differentiating MR imaging features. [ABSTRACT FROM AUTHOR]
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- 2020
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