1. Perivascular fat attenuation index and high-risk plaque features evaluated by coronary CT angiography: relationship with serum inflammatory marker level.
- Author
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Dai X, Deng J, Yu M, Lu Z, Shen C, and Zhang J
- Subjects
- Adipose Tissue physiopathology, Adiposity, Adult, Aged, Aged, 80 and over, Biomarkers blood, Coronary Artery Disease blood, Coronary Artery Disease complications, Coronary Artery Disease physiopathology, Coronary Stenosis blood, Coronary Stenosis complications, Coronary Stenosis physiopathology, Coronary Vessels physiopathology, Female, Humans, Male, Middle Aged, Plaque, Atherosclerotic, Predictive Value of Tests, Prognosis, Risk Assessment, Risk Factors, Severity of Illness Index, Adipose Tissue diagnostic imaging, C-Reactive Protein analysis, Computed Tomography Angiography, Coronary Angiography methods, Coronary Artery Disease diagnostic imaging, Coronary Stenosis diagnostic imaging, Coronary Vessels diagnostic imaging, Inflammation Mediators blood, Multidetector Computed Tomography
- Abstract
The present study aimed to investigate the association between perivascular fat attenuation index (FAI), high-risk plaque features and serum level of high sensitive C-reactive protein (hs-CRP). Consecutive patients with intermediate pre-test probability of CAD, who were referred for coronary CT angiography (CCTA), were included. High-risk plaque features were assessed by CCTA and included low attenuation plaque (LAP), positive remodeling (PR), napkin-ring sign (NRS) and spotty calcification. Lesion specific perivascular FAI was also measured for all plaques located on major epicardial vessels with diameter ≧ 2 mm. Laboratory test results, including hs-CRP, were recorded. 199 patients with 260 lesions were finally included. NRS and LAP were more commonly present in the group with elevated hs-CRP (35.9% vs. 19.4% and 14.1% vs. 2.6%, both p < 0.05) and more severe stenosis extent was also noted for this group. However, there was no significant difference between the elevated hs-CRP and normal hs-CRP group with respect to other CT parameters, such as lesion length, PR, spotty calcification and focal calcium score. Perivascular FAI failed to show significant difference between the two groups (- 69.8 ± 10.3HU vs. - 70.0 ± 12.0HU, p = 0.953) and there was poor correlation between perivascular FAI and hs-CRP measurements (r = - 0.04, p = 0.510). In conclusion, LAP and NRS are more commonly present in CAD patients with elevated level of hs-CRP. However, perivascular FAI failed to show such correlation with serum level of hs-CRP.
- Published
- 2020
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