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(a-c) Minimal inhibitory concentration (MIC), fractional inhibitory concentration index (FICI) and dose reduction index (DRI) of the combination effect of (a) narasin and N-acetylcysteine (NAC), (b) narasin and Tris-EDTA and (c) narasin and disodium EDTA (a-c) Minimal inhibitory concentration (MIC), fractional inhibitory concentration index (FICI) and dose reduction index (DRI) of the combination effect of (a) monensin and N-acetylcysteine (NAC), (b) monensin and Tris-EDTA and (c) monensin and disodium EDTA for various bacterial isolates (a-c) Minimal inhibitory concentration (MIC), fractional inhibitory concentration index (FICI) and dose reduction index (DRI) of the combination effect of (a) monensin and N-acetylcysteine (NAC), (b) monensin and Tris-EDTA and (c) monensin and disodium EDTA for various bacterial isolates (a-c) Minimal inhibitory concentration (MIC), fractional inhibitory concentration index (FICI) and dose reduction index (DRI) of the combination effect of (a) monensin and N-acetylcysteine (NAC), (b) monensin and Tris-EDTA and (c) monensin and disodium EDTA for various bacterial isolates. [Extracted from the article]

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Antimicrobial resistance and antimicrobial stewardship are of ever-increasing importance in veterinary medicine. Multidrug-resistant infections of the canine skin and ear continue to emerge, but the use of antibiotic classes of critical importance to human medicine may not represent good antimicrobial stewardship. Repurposing of old drugs that are not used in human medicine is one approach that addresses both these issues. In this study, the minimal inhibitory concentration (MIC) of monensin for 111 bacterial and yeast canine otitis isolates was determined using microdilution methodology according to Clinical Laboratory Standards Institute (CLSI) guidelines. Monensin was effective against all Gram-positive bacteria including the multidrug-resistant staphylococcal strains with MICs ranging from 1 to 4 μg/ml, but lacked antimicrobial activity against Gram-negative bacteria and yeast isolates. Monensin has potential to be incorporated as one of the main components in an otic formulation. [ABSTRACT FROM AUTHOR]