5 results on '"KOÇ, EMINE"'
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2. Sectoral and Quadrant Evaluation of the Peripapillary Retinal Nerve Fiber Layer and Ganglion Cell--inner Plexiform Layer Thickness in Patients with Multiple Sclerosis.
- Author
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Koç, Emine Rabia, Sarı, Esin Söğütlü, Yazıcı, Alper, Sarıdaş, Furkan, and Turan, Ömer Faruk
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RETINAL anatomy , *MULTIPLE sclerosis , *NEURONS , *RETINAL ganglion cells , *NEURAL pathways , *COMPARATIVE studies , *OPTIC nerve , *OPTICAL coherence tomography , *CENTRAL nervous system ,OCULAR radiography - Abstract
Objective: To evaluate the peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell--inner plexiform layer thickness (GC--IPL) in patients with multiple sclerosis (MS) by sector and quadrant. Materials and Methods: Seventy-eight eyes of 39 patients with MS and 82 eyes of 41 healthy participants were analyzed using spectral domain optical coherence tomography. Our study defined MS eyes with optic neuritis (ON) as MS ON eyes and those without ON as MS non-ON eyes. Comparisons of the GC-- IPL and pRNFL thicknesses were assessed and the measurements compared with healthy controls (HCs). Results: The comparison of the average and three quadrants (superior, inferior, and temporal) measurements of the pRNFL thickness and the average and six quadrant measurements of the GC--IPL thickness between the MS ON eyes and the MS non-ON eyes revealed statistically significant differences (P < 0.05). The average and four quadrants thickness of pRNFL and the average and six quadrants thickness of GC--IPL were significantly reduced in a comparison of MS ON vs. HC with MS non-ON vs. HC eyes (P < 0.05). Conclusion: The evaluation of pRNFL and GC--IPL thicknesses in MS ON and MS non-ON eyes may be beneficial in determining the central nervous system axonal integrity. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. D Vitamininin Fingolimod Tedavisi Alan Multipl Skleroz Hastaları Üzerine Etkisinin Araştırılması.
- Author
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SARIDAŞ, Furkan, LAZRAK, Sarra Hamide, KOÇ, Emine Rabia, and TURAN, Ömer Faruk
- Abstract
Copyright of Journal of Uludag University Medical Faculty / Uludağ Üniversitesi Tıp Fakültesi Dergisi is the property of Journal of Uludag University Medical Faculty and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2023
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- View/download PDF
4. Affective temperament profiles in patients with multiple sclerosis: Association with mood disorders
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Özkan, Adile, Altınbaş, Kürşat, Koç, Emine Rabia, Şen, Halil Murat, Karaman, Handan Işın Özışık, and Tıp Fakültesi
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Multiple Sclerosis ,Bipolarite ,Nörolojik Bilimler ,Multipl Skleroz ,Bipolarity ,Afektif Mizaç ,Affective Temperament ,Psikiyatri - Abstract
Koç, Emine Rabia (Balikesir Author), Amaç: Bu çalışmanın amacı bipolariteyi taramak ve Multipl Skleroz (MS) hastalarında afektif mizaç özelliklerini ve MS hastalarının klinik ve demografik özellikleri arasındaki olası ilişkiyi ve mizaç profillerini araş- tırmaktır. Yöntemler: Toplam 65 MS hastası ile 66 sağlıklı gönüllü HCl-32, Duygu Durum Bozuklukları Anketini (MDQ) ve Temperament Evaluation of Memphis, Pisa, Paris and San Diego-Autoquestionnaire (TEMPS-A) testlerini tamamlamıştır. HCl-32, MDQ ve TEMPS-A skorları hastalar ve sağlıklı gönüllu?ler arasında karşılaştırılmıştır. Bulgular: Kontrol grubuyla karşılaştırıldığında MS hastalarının TEMPS-A ölçeğinin depresif, siklotimik, irritabl ve anksiyöz alanlarında belirgin derecede yüksek skorları vardır. Sekonder progresif hastalarıyla kar- şılaştırıldığında relapsing remitting MS hastalarının MDQ ve TEMPS-A hipertimi skorları daha yüksektir. İnterferon beta 1-b tedavisi alan MS hastalarının MDQ skorları interferon beta 1-a, glitamer asetat ile tedavi edilen veya ilaç tedavisi görmeyen MS hastalarından belirgin derecede yüksektir. Genişletilmiş Özürlülük Durum Skalası (EDSS) skorları Temps-A depresif ve hipertimik mizaçla pozitif olarak ilişkilendirilmiştir. Sonuç: Bulgularımız, MS hastalarında afektif mizaç için yüksek skorların duygu durum bozukluklarının subklinik tablolarını belirtebileceğini önermektedir. RRMS grubunda saptanan yüksek hipertimi skorları ve manik semptomlar bipolarite ile multipl skleroz arasındaki ilişkiyi açıklığa kavuşturabilir. Dolayısıyla, MS hastalarında bipolarite ve afektif mizaç profillerinin taranması klinisyenlerin gelecek duygu durum epizodlarını öngörebilmelerine ve hastalığın şiddeti üzerindeki etkisinin azalmasına yardımcı olabilecektir., Introduction: The aim of the present study was to screen for bipolarity and to investigate the affective temperaments of patients with multiple sclerosis (MS) and the possible association between the clinical and demographic characteristics of MS patients and temperament profiles. Methods: A total of 65 patients with MS and 66 healthy volunteers completed the 32-item hypomania checklist (HCl-32), the Mood Disorder Questionnaire (MDQ), and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A) tests. The HCl-32, MDQ, and TEMPS-A scores were compared between the patients and healthy volunteers. Results: MS patients had significantly higher scores for the depressive, cyclothymic, irritable, and anxious domains of the TEMPS-A scale than the control group, whereas relapsing remitting MS (RRMS) patients had higher MDQ and TEMPS-A hyperthymia scores than secondary progressive MS patients. MS patients who were being treated with interferon beta 1-b therapy had significantly higher MDQ scores than those being treated with interferon beta 1-a, glatiramer acetate, or who were without medication. Expanded Disability Status Scale (EDSS) scores were positively correlated with TEMPS-A depressive and hyperthymic temperaments. Conclusion: Our results suggest that higher scores for affective temperament in MS patients indicate subclinical manifestations of mood disorders. Higher hyperthymia scores and manic symptoms detected in the RRMS group could shed light on the relationship between bipolarity and MS. Thus, the screening of bipolarity and affective temperament profiles in MS patients could help clinicians predict future mood episodes and decrease their impact on disease severity
- Published
- 2016
5. Multipl skleroz hastalarında otonom sinir sistemi ile ilişkili sempatik cilt yanıtlarının değerlendirilmesi ve yorgunluk skorları.
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Yetik, Şeyda Bayil, Koç, Emine Rabia, and Erdemoğlu, Ali Kemal
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FATIGUE (Physiology) , *SKIN physiology , *DYSAUTONOMIA , *QUALITY of life , *AUTONOMIC nervous system diseases ,MULTIPLE sclerosis research - Abstract
Objectives: In this study we aimed to investigate the effect of autonomic dysfunction on quality of life and symptoms of fatigue patients with MS. Materials and methods: The study included 30 patients with MS and 35 healthy subjects as control group. Disability was assessed using the Expanded Disability Status Scale (EDSS); autonomic functions were assessed by SSR; fatigue symptoms were assessed by Fatigue Descriptive Scale (FDS); effect of autonomic dysfunction on quality of life and fatigue symptoms was assessed by SF-36 scale. Results: There was no significant difference between the left hand SSR latency, mean amplitude and area between patient and control groups. Mean FDS value was significantly higher in MS group. SSR amplitude and area were significantly smaller in patients which received prophylactic treatment. There was no relation between the FDS scores and SSR values in patients receiving prophylaxis. In the patient group, a positive correlation was detected between EDSS and FDS score; and significantly negative correlation between pyramidal, cerebellar and spasticity; a significant positive correlation was found between amplitude and the size of area of the SSR and brain stem functions. There was no significant relationship between FDS with SSR area, latency and amplitude. Conclusions: SSR measurements are not sensitive in order to evaluate autonomic dysfunction in patients with multiple sclerosis. Symptoms of fatigue has a negatively affect on the activity of the patient's daily life. SSR test is not sufficient to show the relationship between fatigue and autonomic dysfunction. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
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