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Copyright of Journal of Uludag University Medical Faculty / Uludağ Üniversitesi Tıp Fakültesi Dergisi is the property of Journal of Uludag University Medical Faculty and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To evaluate the peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell--inner plexiform layer thickness (GC--IPL) in patients with multiple sclerosis (MS) by sector and quadrant. Materials and Methods: Seventy-eight eyes of 39 patients with MS and 82 eyes of 41 healthy participants were analyzed using spectral domain optical coherence tomography. Our study defined MS eyes with optic neuritis (ON) as MS ON eyes and those without ON as MS non-ON eyes. Comparisons of the GC-- IPL and pRNFL thicknesses were assessed and the measurements compared with healthy controls (HCs). Results: The comparison of the average and three quadrants (superior, inferior, and temporal) measurements of the pRNFL thickness and the average and six quadrant measurements of the GC--IPL thickness between the MS ON eyes and the MS non-ON eyes revealed statistically significant differences (P < 0.05). The average and four quadrants thickness of pRNFL and the average and six quadrants thickness of GC--IPL were significantly reduced in a comparison of MS ON vs. HC with MS non-ON vs. HC eyes (P < 0.05). Conclusion: The evaluation of pRNFL and GC--IPL thicknesses in MS ON and MS non-ON eyes may be beneficial in determining the central nervous system axonal integrity. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Uludag University Medical Faculty / Uludağ Üniversitesi Tıp Fakültesi Dergisi is the property of Journal of Uludag University Medical Faculty and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objectives: In this study we aimed to investigate the effect of autonomic dysfunction on quality of life and symptoms of fatigue patients with MS. Materials and methods: The study included 30 patients with MS and 35 healthy subjects as control group. Disability was assessed using the Expanded Disability Status Scale (EDSS); autonomic functions were assessed by SSR; fatigue symptoms were assessed by Fatigue Descriptive Scale (FDS); effect of autonomic dysfunction on quality of life and fatigue symptoms was assessed by SF-36 scale. Results: There was no significant difference between the left hand SSR latency, mean amplitude and area between patient and control groups. Mean FDS value was significantly higher in MS group. SSR amplitude and area were significantly smaller in patients which received prophylactic treatment. There was no relation between the FDS scores and SSR values in patients receiving prophylaxis. In the patient group, a positive correlation was detected between EDSS and FDS score; and significantly negative correlation between pyramidal, cerebellar and spasticity; a significant positive correlation was found between amplitude and the size of area of the SSR and brain stem functions. There was no significant relationship between FDS with SSR area, latency and amplitude. Conclusions: SSR measurements are not sensitive in order to evaluate autonomic dysfunction in patients with multiple sclerosis. Symptoms of fatigue has a negatively affect on the activity of the patient's daily life. SSR test is not sufficient to show the relationship between fatigue and autonomic dysfunction. [ABSTRACT FROM AUTHOR]