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Objective: To study the clinical course of multiple drug resistance in patients with tuberculous spondylitis in the Kyrgyz Republic. Methods: Analyzed 877 medical histories of patients with tuberculous spondylitis of the cervical, thoracic, lumbar and lumbosacral spine, which was on treatment in the Department of Bones and Joints Tuberculosis Surgery from 2013 to 2017. Results: It is established that 715 patients (81.5%) had a sensitive form of tuberculous spondylitis; 153 (17.4%) is primarily resistant and 9 (0.8%) is a secondarily resistant form. In the group of patients in the sensitive form of tuberculosis men were 370, women 345, and among the patients with the resistant form of tuberculous spondylitis of men and women were 86 and 76 people respectively. Conclusion: Over the period of 2013-2017 y., the Kyrgyz Republic marked the growth in multi-drug resistant forms of tuberculous spondylitis with the rapid development of formidable neurological complications, such as meningitis, paresis, paraparesis, paralysis, and dysfunctions of pelvic organs.