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Your search keyword '"Rosa, Gennaro"' showing total 4 results
Start Over Author "Rosa, Gennaro" Topic multiple myeloma
4 results on '"Rosa, Gennaro"'

1. Tc99m-sestaMIBI uptake in nonsecretory multiple myeloma.

Author

Catalano L, Andretta C, Pace L, Del Vecchio S, Salvatore B, De Rosa G, Buonanno MT, Paone G, and Rotoli B

Subjects
Aged, Female, Humans, Male, Middle Aged, Monitoring, Physiologic, Multiple Myeloma therapy, Radiography, Radionuclide Imaging methods, Multiple Myeloma diagnostic imaging, Radiopharmaceuticals administration & dosage, Technetium Tc 99m Sestamibi administration & dosage
Abstract

Staging and monitoring of multiple myeloma (MM) is mainly based on monoclonal component quantification; the absence of such a parameter renders difficult follow up of patients with nonsecretory MM (nsMM). In this study our aims were to determine the specificity and sensitivity of Tc99m-sestaMIBI scintigraphy at diagnosis and during follow up of nsMM patients. Nine nsMM patients were prospectively studied at diagnosis and during treatment for a mean time of 33 months (range: 12-65+). Tc99m-sestaMIBI (MIBI) scintigraphy was compared to conventional imaging (CI: X ray with CAT or NMR details) at diagnosis and during follow up. At diagnosis, CI and MIBI were concordant in three patients; CI showed more focal lesions than MIBI in four patients, while MIBI revealed more focal lesions than CI in two patients. During the follow up, MIBI uptake was normal in the four patients who achieved remission. Five patients did not achieve remission: CI and MIBI were concordant in three, while MIBI was falsely negative in two patients. In conclusion, Tc99m-sestaMIBI scintigraphy has high sensitivity (no false positive cases) and 78% specificity (2/9 false negative cases) in tracing active nsMM lesions; it should be considered complementary to CI for monitoring this rare disease.

Published
2005
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2. Multiple myeloma cured by conventional chemotherapy: a report and a review.

Author

Notaro R, De Renzo A, De Rosa G, Karadimitris A, and Rotoli B

Subjects
Adult, Bone and Bones diagnostic imaging, Humans, Male, Multiple Myeloma diagnostic imaging, Radionuclide Imaging, Technetium Tc 99m Sestamibi, Multiple Myeloma drug therapy
Abstract

A young man presented with overt multiple myeloma at the age of 28, and received cyclophosphamide pulses every 3-4 weeks for more than 3 years. He has remained in continuous complete remission for the past 23 years without further treatment and without evidence of disease. Five cases of multiple myeloma cured by conventional chemotherapy reported in literature are reviewed here.

Published
2002
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3. Avid (67)Ga uptake in multiple myeloma relapsing after bone marrow transplant

Author

DE ROSA, GENNARO, PEZZULLO L., DEL VECCHIO S., De Rosa, G, Pezzullo, L, DEL VECCHIO, Silvana, DE ROSA, Gennaro, Pezzullo, L., and DEL VECCHIO, S.

Subjects
Adult, Male, Technetium Tc 99m Sestamibi, Fatal Outcome, Recurrence, Humans, Gallium Radioisotopes, Multiple Myeloma, Radionuclide Imaging, Bone and Bones, Bone Marrow Transplantation
Abstract

Technetium-99m-sestaMIBI is a reliable positive tracer of skeletal lesions in multiple myeloma (MM), while bone scintigraphy by 99mTc-MDP and 67Ga scanning are considered of negligible value. We report the case of a young patient with a 5-year history of light chain MM, which was not eradicated by chemotherapy, radiotherapy, allogeneic bone marrow transplantation, α-interferon and donor lymphocyte infusion. In the final phase of the disease a CT scan showed a 14 cm mediastinal mass (Figure 1A). The neoplastic tissue took up 67Ga more avidly than 99mTc-sesta MIBI (Figures 1B-C), and focal bone lesions showed 67Ga uptake even in areas negative by MIBI scan. The patient died of disease progression in a few months. It seems that a 67Ga scan can identify patients with very aggressive MM.

Published
2000

4. Tc99m-sestaMIBI uptake in nonsecretory multiple myeloma

Author

Lucio Catalano, Barbara Salvatore, Silvana Del Vecchio, Maria Teresa Buonanno, Gennaro De Rosa, Bruno Rotoli, Claudia Andretta, Leonardo Pace, Gaetano Paone, Catalano, L, Andretta, C, Pace, L, DEL VECCHIO, Silvana, Salvatore, B, De Rosa, G, Buonanno, Mt, Paone, G, Rotoli, B., Del Vecchio, S, and DE ROSA, Gennaro

Subjects
Male, Technetium Tc 99m Sestamibi, medicine.diagnostic_test, business.industry, conventional imaging, Hematology, Middle Aged, Scintigraphy, medicine.disease, Tc99m Sestamibi, Tc99m-sestaMIBI scintigraphy, Monoclonal component, Radiography, medicine, Humans, Female, Radiopharmaceuticals, Multiple Myeloma, Radionuclide Imaging, Nonsecretory multiple myeloma, Nuclear medicine, business, Multiple myeloma, Aged, Monitoring, Physiologic
Abstract

Staging and monitoring of multiple myeloma (MM) is mainly based on monoclonal component quantification; the absence of such a parameter renders difficult follow up of patients with nonsecretory MM (nsMM). In this study our aims were to determine the specificity and sensitivity of Tc99m-sestaMIBI scintigraphy at diagnosis and during follow up of nsMM patients. Nine nsMM patients were prospectively studied at diagnosis and during treatment for a mean time of 33 months (range: 12 - 65 þ ). Tc99m-sestaMIBI (MIBI) scintigraphy was compared to conventional imaging (CI: X ray with CAT or NMR details) at diagnosis and during follow up. At diagnosis, CI and MIBI were concordant in three patients; CI showed more focal lesions than MIBI in four patients, while MIBI revealed more focal lesions than CI in two patients. During the follow up, MIBI uptake was normal in the four patients who achieved remission. Five patients did not achieve remission: CI and MIBI were concordant in three, while MIBI was falsely negative in two patients. In conclusion, Tc99m-sestaMIBI scintigraphy has high sensitivity (no false positive cases) and 78% specificity (2/9 false negative cases) in tracing active nsMM lesions; it should be considered complementary to CI for monitoring this rare disease.

Published
2005

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