1. Disease stability over five years in people with multiple sclerosis treated with cladribine tablets: a plain language summary.
- Author
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Giovannoni G, Comi G, Rammohan K, Rieckmann P, Dangond F, Jack D, and Vermersch P
- Subjects
- Humans, Cladribine therapeutic use, Language, Immunosuppressive Agents therapeutic use, Tablets therapeutic use, Multiple Sclerosis drug therapy, Multiple Sclerosis, Relapsing-Remitting drug therapy
- Abstract
What Is This Summary About?: This is a summary of an article originally published in the journal Advances in Therapy . Cladribine tablets are approved for treating people with relapsing multiple sclerosis (shortened to MS). People with MS take cladribine tablets for 2 periods of 4 to 5 days per year. This analysis looks at the results from 2 studies called the CLARITY and CLARITY Extension studies. These studies looked at what effect a 2-year course of treatment with cladribine tablets had on disability over 5 years in people with MS., How Was the Analysis Carried Out?: In this analysis, researchers measured disability worsening at regular intervals during the 2-year treatment period in the CLARITY study and thereafter in the 2-year CLARITY Extension study. As many patients had a bridging interval between CLARITY and CLARITY extension, the researchers were able to assess disability over a 5-year timeframe., What Were the Results?: When measurements were taken at Year 5 of the study, disability remained stable in more than half of participants. Over the 5-year period, 70% of participants did not experience persistent disease worsening that lasted more than 6 months., What Do the Results Mean?: Researchers concluded that a 2-year course of cladribine tablets may provide long-term benefits on disability for up to 5 years. Clinical Trial Registration : NCT00213135 (ClinicalTrials.gov) Clinical Trial Registration : NCT00641537 (ClinicalTrials.gov).
- Published
- 2022
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