1. Neuromyelitis optica and multiple sclerosis in sisters.
- Author
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Cabrera-Gómez JA, Ramón-Pérez L, Saiz A, Llerena-Fernández P, Fernández-Fernández L, Ercilla G, Grass-Fernández D, Robinson-Agramonte MA, Romero-García K, Macías-Betancourt R, Galvizu-Sánchez R, Otero-Motolá C, Sojo-Gómez M, Aguilar-Arias C, Rodríguez-Cordero M, and González-Quevedo A
- Subjects
- Adult, Family Health, Female, Humans, Magnetic Resonance Imaging, Multiple Sclerosis ethnology, Multiple Sclerosis pathology, Neuromyelitis Optica ethnology, Neuromyelitis Optica pathology, Siblings, Venezuela, White People genetics, Histocompatibility Testing, Multiple Sclerosis genetics, Neuromyelitis Optica genetics
- Abstract
Introduction: The association of neuromyelitis optica (NMO) and multiple sclerosis (MS) has been reported, but details of the cases were not described. We report two Venezuelan Caucasian sisters with human leukocyte antigen (HLA) typing., Results: Patient 1 fulfilled McDonald, et al. criteria with HLA A*24; B*07,*15; DRB1*01,*16 (DR2 positive). Patient 2 fulfilled the NMO revised criteria of Wingerchuck, et al. with HLA A*02,*24; B*07,*40; DRB1*04,*08, similar to Canadian aboriginal NMO cases and the Yukpa population from Venezuela., Conclusion: These cases confirmed the coexistence of NMO and MS in sisters, and further studies are needed to understand the genetic linkage between these diseases.
- Published
- 2009
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