1. Vitamin D and muscle health: insights from recent studies.
- Author
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Kuwabara A, Matsumoto M, Hatamoto Y, and Fujita S
- Subjects
- Humans, Dietary Supplements, Muscle Strength drug effects, Muscle Strength physiology, Animals, Vitamin D Deficiency physiopathology, Aged, Cross-Sectional Studies, Middle Aged, Observational Studies as Topic, Vitamin D analogs & derivatives, Sarcopenia prevention & control, Muscle, Skeletal metabolism, Muscle, Skeletal physiology
- Abstract
Purpose of Review: The purpose of this review is to critically evaluate the effects of vitamin D on muscle mass and physical/muscle function in middle-aged and older adults, based on recent human studies, including cross-sectional, observational, and intervention studies. Vitamin D, beyond its well established role in bone health, has shown potential in influencing muscle physiology, making it a nutrient of interest in the context of sarcopenia and related chronic conditions., Recent Findings: The review states how vitamin D affects muscle function, emphasizing its role in muscle cell proliferation, differentiation, and key signaling pathways. Additionally, the review of recent human studies revealed an inconsistent relationship between vitamin D and sarcopenia and related indices, with mixed results regarding muscle mass and strength. Variability in supplementation dose, duration, and baseline 25-hydroxyvitamin D levels may contribute to these inconsistencies., Summary: While animal studies indicate vitamin D's effectiveness in muscle growth, cross-sectional, observational, and intervention studies do not show clear benefits of maintaining efficient vitamin D levels on muscle mass or function in humans. Although vitamin D impacts muscle health, it is insufficient alone, emphasizing the need for a multifaceted approach to sarcopenia prevention and management., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
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