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Your search keyword '"Pariani S"' showing total 2 results
Start Over Author "Pariani S" Topic mutagens
2 results on '"Pariani S"'

1. Cyclophosphamide increases the frequency of sister chromatid exchange in direct preparations of human chorionic villi in the absence of supplementary enzymatic activation systems.

Author

Pariani S, Buscaglia M, Piantanida M, and Simoni G

Subjects
Biotransformation, Cyclophosphamide metabolism, Female, Humans, Mitomycin toxicity, Mutagenicity Tests methods, Mutagens metabolism, Pregnancy, Chorionic Villi drug effects, Cyclophosphamide toxicity, Mutagens toxicity, Sister Chromatid Exchange drug effects
Abstract

A study was performed to evaluate the effect on the frequency of sister chromatid exchange in first trimester chorionic villi of two chemical compounds, mitomycin C and cyclophosphamide. Mitomycin C is generally known to induce an increase in sister chromatid exchange both in vivo and in vitro standard conditions. Cyclophosphamide is a compound requiring additional enzymatic enrichment of the culture medium to express its mutagenic activity under in vitro conditions. We exposed chorionic villi samples to these chemicals without the use of conventional cell cultures and without adding enzymatic extracts to the medium. The results indicate a statistically significant increase in the frequency of sister chromatid exchange after exposure to both compounds and also at lower dosages.

Published
1992
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2. Cyclophosphamide increases the frequency of sister chromatid exchange in direct preparations of human chorionic villi in the absence of supplementary enzymatic activation systems

Author

M. Piantanida, Giuseppe Simoni, Mauro Buscaglia, and Pariani S

Subjects
Mitomycin, Sister chromatid exchange, Mutagen, Biology, medicine.disease_cause, In vivo, Pregnancy, Genetics, medicine, Humans, Cyclophosphamide, Genetics (clinical), Biotransformation, chemistry.chemical_classification, Mutagenicity Tests, Mitomycin C, Molecular biology, In vitro, Enzyme, medicine.anatomical_structure, chemistry, Biochemistry, Cell culture, embryonic structures, Chorionic villi, Female, Chorionic Villi, Sister Chromatid Exchange, Research Article, Mutagens
Abstract

A study was performed to evaluate the effect on the frequency of sister chromatid exchange in first trimester chorionic villi of two chemical compounds, mitomycin C and cyclophosphamide. Mitomycin C is generally known to induce an increase in sister chromatid exchange both in vivo and in vitro standard conditions. Cyclophosphamide is a compound requiring additional enzymatic enrichment of the culture medium to express its mutagenic activity under in vitro conditions. We exposed chorionic villi samples to these chemicals without the use of conventional cell cultures and without adding enzymatic extracts to the medium. The results indicate a statistically significant increase in the frequency of sister chromatid exchange after exposure to both compounds and also at lower dosages.

Published
1992

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