23 results on '"Flachskampf, Frank A."'
Search Results
2. Changes in global longitudinal strain and left ventricular ejection fraction during the first year after myocardial infarction: results from a large consecutive cohort.
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Baron T, Christersson C, Hjorthén G, Hedin EM, and Flachskampf FA
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- Aged, Cohort Studies, Echocardiography, Female, Humans, Male, Middle Aged, Retrospective Studies, Ventricular Function, Left physiology, Myocardial Infarction diagnostic imaging, Myocardial Infarction physiopathology, Stroke Volume physiology, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left physiopathology
- Abstract
Aims: To determine changes of global longitudinal strain (GLS) and their predictors in relation to classical echocardiographic parameters of left ventricular (LV) function, over 1 year, in consecutive patients with myocardial infarction (MI) and initially normal or impaired LV ejection fraction (EF)., Methods and Results: A total of 285 patients with MI prospectively included in the REBUS (RElevance of Biomarkers for future risk of thromb-oembolic events in UnSelected post-myocardial infarction patients) study underwent echocardiography within 72 h from admission and after 1 year. At baseline, 213 (74.7%) of MI patients had a normal EF (≥52% in men or ≥54% in women), but in 70.4% of them, an impaired GLS ( ≥ -18.0%) was observed. During 1-year follow-up, in patients with normal EF at baseline, GLS improved from -15.8% to - 17.4% (10.1% relative change); EF decreased from 62.5% to 59.9% (4.0% relative change); indexed end-diastolic volume, indexed end-systolic volume, and indexed stroke volume increased with 15.6%, 24.8%, and 10.0% of relative change, respectively (P < 0.001 for all the comparisons). In the whole cohort, initial impairment of LV function [by EF, wall motion score index (WMSI), or GLS], male gender, non-smoking, and treatment with beta-blockers were the independent predictors of GLS improvement. In the group with initially impaired EF, over 1 year GLS improved from -11.9% to - 14.8% (24.4% relative change) and EF from 44.6% to 52.6% (18.2% relative change) (P < 0.001 for both). Improvement in GLS significantly correlated with EF increase in the group with impaired EF (r = -0.41, P = 0.001) but not in the patients with normal EF (r = -0.14, P = ns)., Conclusions: Despite diveregent evolution of GLS compared with EF and ventricular volumes, one year after MI GLS significantly improved in patients with initially both normal and impaired EF. Initial impairment of LV function (by EF, WMSI, or GLS), male gender, non-smoking, and treatment with beta-blockers were independent predictors of GLS improvement. LV remodelling was present even in patients with normal EF at baseline and during follow-up, confirming limited functional assessment by EF alone.
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- 2018
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3. Early diagnosis of acute coronary syndrome.
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Katus H, Ziegler A, Ekinci O, Giannitsis E, Stough WG, Achenbach S, Blankenberg S, Brueckmann M, Collinson P, Comaniciu D, Crea F, Dinh W, Ducrocq G, Flachskampf FA, Fox KAA, Friedrich MG, Hebert KA, Himmelmann A, Hlatky M, Lautsch D, Lindahl B, Lindholm D, Mills NL, Minotti G, Möckel M, Omland T, and Semjonow V
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- Angina Pectoris etiology, Biomarkers metabolism, Early Diagnosis, Female, Humans, Male, Risk Assessment, Sensitivity and Specificity, Troponin metabolism, Acute Coronary Syndrome diagnosis, Myocardial Infarction diagnosis
- Abstract
The diagnostic evaluation of acute chest pain has been augmented in recent years by advances in the sensitivity and precision of cardiac troponin assays, new biomarkers, improvements in imaging modalities, and release of new clinical decision algorithms. This progress has enabled physicians to diagnose or rule-out acute myocardial infarction earlier after the initial patient presentation, usually in emergency department settings, which may facilitate prompt initiation of evidence-based treatments, investigation of alternative diagnoses for chest pain, or discharge, and permit better utilization of healthcare resources. A non-trivial proportion of patients fall in an indeterminate category according to rule-out algorithms, and minimal evidence-based guidance exists for the optimal evaluation, monitoring, and treatment of these patients. The Cardiovascular Round Table of the ESC proposes approaches for the optimal application of early strategies in clinical practice to improve patient care following the review of recent advances in the early diagnosis of acute coronary syndrome. The following specific 'indeterminate' patient categories were considered: (i) patients with symptoms and high-sensitivity cardiac troponin <99th percentile; (ii) patients with symptoms and high-sensitivity troponin <99th percentile but above the limit of detection; (iii) patients with symptoms and high-sensitivity troponin >99th percentile but without dynamic change; and (iv) patients with symptoms and high-sensitivity troponin >99th percentile and dynamic change but without coronary plaque rupture/erosion/dissection. Definitive evidence is currently lacking to manage these patients whose early diagnosis is 'indeterminate' and these areas of uncertainty should be assigned a high priority for research., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com.)
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- 2017
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4. Usefulness of traditional echocardiographic parameters in assessment of left ventricular function in patients with normal ejection fraction early after acute myocardial infarction: results from a large consecutive cohort.
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Baron T, Flachskampf FA, Johansson K, Hedin EM, and Christersson C
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- Aged, Biomarkers blood, Comorbidity, Electrocardiography, Female, Humans, Male, Myocardial Infarction complications, Myocardial Infarction physiopathology, Prospective Studies, Stroke Volume, Troponin blood, Ventricular Dysfunction, Left physiopathology, Echocardiography, Myocardial Infarction diagnostic imaging, Ventricular Dysfunction, Left diagnostic imaging
- Abstract
Aims: The aim of this study was to assess the frequency of left ventricular (LV) systolic function impairment using classical echocardiographic parameters and their relation to myocardial damage in patients hospitalized for acute myocardial infarction (MI) with normal LV ejection fraction (LVEF ≥52% in males or ≥54% in females)., Methods and Results: All 421 consecutive patients with MI included in the REBUS (RElevance of Biomarkers for future risk of thromboembolic events in UnSelected post-myocardial infarction patients) study underwent two-dimensional and Doppler echocardiography within 72 h after admission. A normal LVEF was present in 262 (73.8%) of the 355 patients ultimately enrolled in the study. Patients with normal LVEF more often presented with non-ST-elevation myocardial infarction and had less comorbidities when compared with those with impaired LVEF. No differences in demographic factors or relevant medications were observed. Higher value of mean annular plane systolic excursion (MAPSE), lower wall motion score index (WMSI), lower LV as well as left atrial volumes characterized patients with normal LVEF. Impaired MAPSE was present in 64.4%, WMSI >1 in 72.1%, and dilated left atrium in 33.6% of those patients. Maximal cardiac troponin concentration reflecting infarct size showed the strongest association with WMSI (β = 0.35), followed by LVEF (β = -0.29), MAPSE (β = -0.25), and indexed LV end-systolic volume (β = 0.19; P < 0.001 for all the models)., Conclusion: In two-third of patients with MI and normal LVEF, at least one of the other markers of systolic function was outside of the normal range. WMSI reflected the size of MI better than global LV function parameters as LVEF or MAPSE., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.)
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- 2016
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5. Relation of functional echocardiographic parameters to infarct scar transmurality by magnetic resonance imaging.
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Rost C, Rost MC, Breithardt OA, Schmid M, Klinghammer L, Stumpf C, Daniel WG, and Flachskampf FA
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- Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prospective Studies, Reproducibility of Results, Severity of Illness Index, Echocardiography, Doppler methods, Magnetic Resonance Imaging, Cine methods, Myocardial Infarction diagnosis, Myocardium pathology
- Abstract
Background: Identification of viable but dysfunctional myocardium after myocardial infarction is important for management, including the decision for revascularization. Assessment of infarct transmurality (TRM) by late contrast enhancement on magnetic resonance imaging (MRI) is frequently used for this task but has several limitations, particularly its availability. The goal of this study was to compare the value of several simple echocardiographic parameters measured at rest at the bedside for the identification of three degrees of infarct TRM, with contrast-enhanced MRI as the gold standard., Methods: In a prospective, single-center study, 41 patients (33 men; mean age, 62 ± 10 years; 32 with ST-segment elevation infarctions) underwent resting echocardiography and contrast-enhanced MRI <5 days after infarction. Wall motion score, preejection velocity by tissue Doppler, and longitudinal, circumferential, and radial peak systolic strain by speckle-tracking-based strain imaging were assessed, and the findings were compared with infarct TRM stratified by contrast-enhanced MRI (no scar, 0% TRM; nontransmural scar, 1%-50% TRM; and transmural scar, 51%-100% TRM)., Results: Four hundred segments showed no scar, 125 showed nontransmural scar, and 213 showed transmural scar on contrast-enhanced MRI. The sensitivity and specificity of visual wall motion scoring to detect any scar versus no scar were 71% and 81%, respectively, similar to values for circumferential strain (sensitivity and specificity both 81% with a cutoff of -14.5%). Longitudinal and radial strain performed less well, and the presence of preejection velocity performed distinctly worse (45% and 90%, respectively). The sensitivity and specificity for identifying nontransmural versus transmural infarction was better for circumferential strain (78% and 75%, respectively, with a cutoff of -10.5%) than for the other strain types, preejection velocity (52% and 67%, respectively), or visual wall motion scoring (50% and 81%, respectively, for a score > 2)., Conclusion: Visual wall motion analysis alone is able to detect infarcted myocardium but cannot differentiate sufficiently between transmural and nontransmural infarction. This is best achieved at the bedside using speckle-tracking-based circumferential strain., (Copyright © 2014 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.)
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- 2014
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6. A patient with ischaemic cardiomyopathy.
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Schmid M and Flachskampf FA
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- Cardiomyopathy, Dilated drug therapy, Cardiotonic Agents therapeutic use, Chest Pain etiology, Echocardiography, Electrocardiography, Humans, Male, Middle Aged, Myocardial Infarction drug therapy, Cardiomyopathy, Dilated diagnosis, Myocardial Infarction diagnosis
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- 2014
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7. Mild therapeutic hypothermia after out-of-hospital cardiac arrest complicating ST-elevation myocardial infarction: long-term results in clinical practice.
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Zimmermann S, Flachskampf FA, Schneider R, Dechant K, Alff A, Klinghammer L, Rittger H, and Achenbach S
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- Aged, Coronary Angiography, Female, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction diagnosis, Myocardial Infarction mortality, Myocardial Infarction therapy, Nervous System physiopathology, Neurologic Examination, Odds Ratio, Out-of-Hospital Cardiac Arrest diagnosis, Out-of-Hospital Cardiac Arrest etiology, Out-of-Hospital Cardiac Arrest mortality, Out-of-Hospital Cardiac Arrest physiopathology, Percutaneous Coronary Intervention instrumentation, Platelet Aggregation Inhibitors therapeutic use, Recovery of Function, Retrospective Studies, Risk Factors, Stents, Time Factors, Time-to-Treatment, Treatment Outcome, Hypothermia, Induced adverse effects, Hypothermia, Induced mortality, Myocardial Infarction complications, Out-of-Hospital Cardiac Arrest therapy
- Abstract
Background: Recently, mild therapeutic hypothermia (MTH) has been integrated into the European resuscitation guidelines to improve outcomes after out-of-hospital cardiac arrest (OHCA). Data on long-term results are limited, especially in patients with acute ST-elevation myocardial infarction (STEMI)., Hypothesis: Invasive MTH influences long-term prognosis after OHCA due to STEMI., Methods: We analyzed 48 patients who underwent emergency coronary angiography for STEMI after witnessed OHCA. In 24 consecutive patients, MTH was performed via intravascular cooling (CoolGard System, 34°C maintained for 24 hours) after initialization by rapid infusion of cold saline. Clinical, procedural, and mortality data were compared to 24 historical controls. Neurological recovery was assessed using the Cerebral Performance Category score (CPC) at 30-day and 1-year follow-up., Results: Median time delay until arrival of emergency medical service was 6 minutes (MTH group) vs 6.5 minutes (controls) (P = 0.16). Initial rhythm was ventricular fibrillation in 75% vs 66.7% (P = 0.75). There were no differences regarding baseline characteristics, angiographic findings, and success of cardiac catheterization procedures. MTH was not associated with a higher frequency of bleeding complications or of pneumonia. Thirty-day mortality was 33.3% in both groups. One-year mortality was 37.5% (MTH group) vs 50% (controls) (P = 0.56). At 1 year, favorable neurological outcome (CPC ≤2) was significantly more frequent in the MTH group (58.3% vs 20.8%, P = 0.017). Multivariate analysis identified MTH as independent predictor of favorable neurological outcome (P < 0.02, odds ratio: 12.73)., Conclusions: MTH via intravascular cooling improves neurological long-term prognosis after OHCA due to STEMI and is safe in clinical practice., (© 2013 Wiley Periodicals, Inc.)
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- 2013
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8. Out-of-hospital cardiac arrest and percutaneous coronary intervention for ST-elevation myocardial infarction: long-term survival and neurological outcome.
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Zimmermann S, Flachskampf FA, Alff A, Schneider R, Dechant K, Klinghammer L, Stumpf C, Zopf Y, Loehr T, Brand G, Ludwig J, Daniel WG, and Achenbach S
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- Aged, Female, Humans, Male, Middle Aged, Myocardial Infarction diagnosis, Nervous System Diseases diagnosis, Nervous System Diseases prevention & control, Out-of-Hospital Cardiac Arrest diagnosis, Retrospective Studies, Survival Rate trends, Survivors, Time Factors, Treatment Outcome, Myocardial Infarction mortality, Myocardial Infarction therapy, Nervous System Diseases mortality, Out-of-Hospital Cardiac Arrest mortality, Out-of-Hospital Cardiac Arrest therapy, Percutaneous Coronary Intervention mortality
- Abstract
Background: Predictors of long-term outcome after ST-elevation myocardial infarction (STEMI) complicated by out-of-hospital cardiac arrest (OHCA) are incompletely understood, including the influence of successful coronary reperfusion., Methods: We analysed clinical and procedural data as well as 1-year outcome of 72 consecutive patients who underwent primary coronary intervention (PCI) after witnessed OHCA and STEMI and compared the results with 695 patients with STEMI and PCI, but without OHCA. Neurological recovery after OHCA was assessed using the Cerebral Performance Category (CPC) scale., Results: PCI was successful in 83.3% after OHCA vs. 84.3% in the non-OHCA group (p=0.87). One-year mortality was 34.7% vs. 9.5% (p<0.001). 58.3% of the OHCA-patients showed complete neurological recovery (CPC 1) or moderate neurological disability (CPC 2). Another 6.9% showed severe cerebral disability (CPC 3) or permanent vegetative status (CPC 4). Delay from collapse until start of Advanced Cardiopulmonary Life Support (ACLS) was shorter for survivors with CPC status ≤2 (median 1 min, range 0-11 min) compared to non-survivors or survivors with CPC status >2 (median 8 min, range 0-13 min), p<0.0001. Age-adjusted multivariate analysis identified 'unsuccessful PCI', 'vasopressors on admission' and 'start of ACLS after >6 min' as independent predictors of negative long-term outcome (death or CPC >2)., Conclusions: Mortality is high in patients with STEMI complicated by OHCA - even though PCI was performed with the same success rate as in patients without OHCA. The majority of survivors had favourable neurological outcomes at 1 year, especially if advanced life support had been started within ≤6 min and PCI was successful., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)
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- 2013
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9. Cardiac imaging after myocardial infarction.
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Flachskampf FA, Schmid M, Rost C, Achenbach S, DeMaria AN, and Daniel WG
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- Cardiac Volume physiology, Coronary Angiography methods, Diastole physiology, Echocardiography methods, Humans, Magnetic Resonance Angiography methods, Mitral Valve Insufficiency diagnosis, Mitral Valve Insufficiency etiology, Myocardial Infarction pathology, Myocardial Infarction physiopathology, Myocardial Ischemia etiology, Myocardial Reperfusion methods, Myocardium pathology, Necrosis pathology, Patient Selection, Stress, Physiological physiology, Stroke Volume physiology, Thrombosis diagnosis, Thrombosis etiology, Tomography, X-Ray Computed methods, Ventricular Dysfunction, Left pathology, Ventricular Dysfunction, Left physiopathology, Ventricular Remodeling physiology, Diagnostic Imaging methods, Myocardial Infarction complications
- Abstract
After myocardial infarction, optimal clinical management depends critically on cardiac imaging. Remodelling and heart failure, presence of inducible ischaemia, presence of dysfunctional viable myocardium, future risk of adverse events including risk of ventricular arrhythmias, need for anticoagulation, and other questions should be addressed by cardiac imaging. Strengths and weaknesses, recent developments, choice, and timing of the different non-invasive techniques are reviewed for this frequent clinical scenario.
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- 2011
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10. Raised diastolic pressure as an early predictor of left ventricular remodeling after infarction: should echocardiography or natriuretic peptides be used for assessment?
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Flachskampf FA
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- Diastole, Humans, Myocardial Infarction physiopathology, Predictive Value of Tests, Time Factors, Ultrasonography, Myocardial Infarction blood, Myocardial Infarction diagnostic imaging, Natriuretic Peptides blood, Ventricular Remodeling
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- 2010
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11. Short-term prognosis of contemporary interventional therapy of ST-elevation myocardial infarction: does gender matter?
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Zimmermann S, Ruthrof S, Nowak K, Alff A, Klinghammer L, Schneider R, Ludwig J, Pfahlberg AB, Daniel WG, and Flachskampf FA
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- Aged, Aged, 80 and over, Coronary Artery Disease complications, Female, Follow-Up Studies, Hospitalization, Humans, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction mortality, Myocardial Infarction pathology, Prognosis, Retrospective Studies, Risk Factors, Sex Factors, Time Factors, Angioplasty, Balloon, Coronary, Coronary Angiography, Myocardial Infarction therapy
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Background: A higher mortality risk for women with acute ST-elevation myocardial infarction (STEMI) has been a common finding in the past, even after acute percutaneous coronary intervention (PCI). We set out to analyze whether there are gender differences in real-world contemporary treatment and outcomes of STEMI., Patients and Methods: A retrospective analysis of all consecutive patients with STEMI and acute coronary angiography with the intention of performing a PCI at our center 6/1999-6/2006 was carried out (n = 566). Data were examined for gender-specific differences regarding patients' characteristics, referral patterns, timing of acute symptoms, angiographic findings, procedural details, and adverse events at 30 days after PCI., Results: Women (n = 161) were on average 8 years older than men (n = 405), had higher co-morbidity, were more often transported to the hospital by ambulance and presented less often to the emergency room on their own (4.2% vs. 12.6% in men, P = 0.02). The pre-hospital delay from symptom onset to admission was significantly longer for women (median 185 vs. 135 min, P < 0.02). There was no gender difference in time from admission to PCI (median 46 min vs. 48 min, P = 0.42). Both genders received PCI with similar frequency (88.8% vs. 92.4%, P = 0.19), with similar success rates (83.2% vs. 85.3%, P = 0.68). Thirty-day overall mortality for women was not significantly higher than for men (8.7% vs. 7.2%, P = 0.6). Re-infarction or stroke within 30 days were rare for both genders without gender-specific differences whereas bleeding necessitating blood replacement was significantly more frequent in women (16.8% vs. 5.9%, P < 0.001). In multivariate analysis, female gender was not independently associated with a higher risk of 30-day mortality (OR 0.964, P = 0.93)., Conclusions: Women underwent PCI therapy for STEMI with the same frequency and the same angiographic success as men. Despite their more advanced age and the higher prevalence of co-morbidities, they did not have a significantly higher 30-day mortality rate than men. Female gender was not an independent risk factor of 30-day mortality. Longer pre-hospital delays before hospital admission in women indicate that awareness of risk from coronary artery disease should be further raised in women.
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- 2009
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12. Apical transverse motion as surrogate parameter to determine regional left ventricular function inhomogeneities: a new, integrative approach to left ventricular asynchrony assessment.
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Voigt JU, Schneider TM, Korder S, Szulik M, Gürel E, Daniel WG, Rademakers F, and Flachskampf FA
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- Aged, Case-Control Studies, Feasibility Studies, Humans, Middle Aged, Reproducibility of Results, Stress, Mechanical, Ventricular Dysfunction, Left physiopathology, Ventricular Remodeling physiology, Bundle-Branch Block physiopathology, Myocardial Contraction physiology, Myocardial Infarction physiopathology, Ventricular Dysfunction, Left diagnosis
- Abstract
Aims: Left ventricular (LV) asynchrony assessment is mostly based on delays between regional myocardial velocity peaks. Regional function is barely considered. We propose apical transverse motion (ATM) as a new parameter integrating both temporal and functional information, which was tested in different conduction delays., Methods and Results: We examined 67 patients, 11 patients with post-infarct ischaemic left bundle branch blocks (iLBBB) and 25 patients with non-ischaemic left bundle branch block (nLBBB), 12 patients with right bundle branch block (RBBB), and 19 normal healthy volunteers (NORM). Longitudinal colour tissue Doppler data were used to calculate the total transverse apex motion (ATM), the transverse motion in the four-chamber view plane alone (ATM(4CV)) as well as regional myocardial deformation and conventional LV asynchrony parameters. Median ATM was 1.8 mm in NORM, 1.5 mm in RBBB (P = 0.999), 2.4 mm in iLBBB (P = 0.183), and 4.3 mm in nLBBB (P < 0.001 vs. NORM and RSB). ATM(4CV) behaved similarly, showed a good correlation with regional deformation data, and distinguished well between NORM and LBBB (AUC = 0.87)., Conclusion: Apical transverse motion is a new and simple parameter integrating information on both regional and temporal function inhomogeneities of the LV. It has a potential role in assessing LV asynchrony in the clinical context.
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- 2009
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13. Outcomes of contemporary interventional therapy of ST elevation infarction in patients older than 75 years.
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Zimmermann S, Ruthrof S, Nowak K, Klinghammer L, Ludwig J, Daniel WG, and Flachskampf FA
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- Acute Disease, Age Factors, Aged, Aged, 80 and over, Female, Humans, Length of Stay, Logistic Models, Male, Middle Aged, Multivariate Analysis, Myocardial Infarction drug therapy, Myocardial Infarction mortality, Prognosis, Risk Factors, Stroke Volume, Time Factors, Treatment Outcome, Angioplasty, Balloon, Coronary, Coronary Angiography, Myocardial Infarction therapy
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Background: Data on contemporary real-world outcomes of interventional revascularization in patients > or = 75 y of age with ST elevation infarction (STEMI) are limited., Methods: We analyzed all 504 consecutive patients who underwent angiography for acute STEMI between 1999 and 2005 at our center, and followed them up over one year. Outcomes in patients > or = 75 y of age were compared with younger patients., Results: Patients > or = 75 y of age (n = 115) were majority females (55% versus 21%, p < 0.001), more cases of diabetes (42% versus 27%, p = 0.004), hypertension (78% versus 65%, p = 0.03) and a history of coronary events (25% versus 15%, p = 0.002). Younger patients were more often smokers (63% versus 30%, p < 0.001). After coronary angiography patients > or = 75 y of age underwent less frequent intervention (PCI; 84% versus 93%, p = 0.01). However, if PCI was performed, technical success rates were similar to younger patients (84% versus 86%). The 30-d mortality was 13% versus 6.4% (p = 0.03), but after successful PCI, the 30-d mortality rate was not significantly higher in old patients (7.4% versus 3.9%, p = 0.23). Bleeding complications were very low in both age groups if the radial access route was chosen. Multivariate predictors of 30-d mortality were cardiogenic shock/survived cardiac arrest, ejection fraction < 30%, conservative treatment or unsuccessful PCI (OR 3.01), renal insufficiency, diabetes, and age. One-y mortality was higher in the elderly (24.3% versus 9.9%, p < 0.001). Among 30-d-survivors, only multivessel disease and age were multivariate predictors of 1-y mortality., Conclusion: Patients > or = 75 y of age benefit from PCI in STEMI, and failed or unattempted PCI worsens prognosis in the old as well as in younger patients.
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- 2009
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14. Real-time myocardial contrast echocardiography for assessing perfusion and function in healthy and infarcted wistar rats.
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Wasmeier GH, Zimmermann WH, Schineis N, Melnychenko I, Voigt JU, Eschenhagen T, Flachskampf FA, Daniel WG, and Nixdorff U
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- Animals, Contrast Media, Coronary Circulation, Feasibility Studies, Male, Myocardial Infarction physiopathology, Observer Variation, Phospholipids, Rats, Rats, Wistar, Reproducibility of Results, Sulfur Hexafluoride, Ultrasonography, Ventricular Function, Left, Myocardial Infarction diagnostic imaging
- Abstract
Real-time myocardial contrast echocardiography (MCE) is a noninvasive perfusion imaging method, whereas technical and resolution problems impair its application in small animals. Hence, we investigated the feasibility of MCE in experimental cardiovascular set-ups involving healthy and infarcted myocardium in rats. Twenty-five male Wistar rats were examined under volatile anesthesia (2.5% isoflurane) with high-resolution conventional 2-D echocardiography (2DE) and real-time MCE (Sonos 7,500 with 15MHz-transducer, Philips Medical Systems, Andover, MA, USA) in short-axis view. Contrast agent (SonoVue, Bracco, Milan, Italy) was infused as a bolus into a sublingual vein. Background-subtracted contrast signal intensity (SI) was measured off-line in six end-systolic segments and fitted to an exponential curve (gamma variate). Derived peak SI was subsequently calculated and compared with wall motion and common functional measured quantities (left ventricular end-diastolic diameter [LVEDD], area shortening [AS]). Recordings were performed before and 14 days after left anterior descending (LAD) ligature. Infarction induced anterior wall motion abnormalities (WMA) in all animals (16 akinetic, 9 hypokinetic), increased LVEDD (9.1 +/- 0.6 vs. 7.9 +/- 0.6 mm, p < 0.001), reduced AS (36.1 +/- 10.0 vs. 59.5 +/- 4.1%, p < 0.001) and reduced anterior segmental SI (0.4 +/- 0.4 dB akinetic / 1.7 +/- 1.7 dB hypokinetic vs. 15.8 +/- 10.9 dB preinfarct, p < 0.001 / p < 0.001). Segmental SI in normokinetic segments remained unchanged. Area at risk (perfusion defect) correlated well with WMA (r = 0.838). These data confirmed high-resolution real-time MCE as a rational tool for assessing myocardial perfusion of Wistar rats. It may therefore be a useful diagnostic tool for in-vivo cardiovascular research in small animals.
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- 2008
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15. Incidence and characteristics of segmental postsystolic longitudinal shortening in normal, acutely ischemic, and scarred myocardium.
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Voigt JU, Lindenmeier G, Exner B, Regenfus M, Werner D, Reulbach U, Nixdorff U, Flachskampf FA, and Daniel WG
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- Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Myocardial Infarction diagnostic imaging, Myocardial Infarction physiopathology, Myocardial Ischemia diagnostic imaging, Myocardial Ischemia physiopathology, Stroke Volume, Echocardiography, Doppler, Color, Myocardial Infarction pathology, Myocardial Ischemia pathology, Myocardium pathology
- Abstract
Objective: Myocardial longitudinal shortening after aortic valve closure (postsystolic shortening [PSS]) is considered a marker of pathology with diagnostic potential. However, PSS can also occur in healthy subjects. We, therefore, investigated the occurrence and characteristics of PSS in control subjects and patients, and how to distinguish normality from disease., Methods: In 20 young control subjects, 10 older control subjects, 30 patients with acute myocardial infarction (acute ischemia), and 10 patients with postischemic myocardial scar, longitudinal myocardial deformation was measured with Doppler tissue strain rate (SR) imaging. Segmental SR and strain were visually and quantitatively analyzed and compared., Results: In young control subjects, PSS was found in 98 of 313 segments (31%) and showed gaussian distribution (median 1.3%). During ejection time, median peak SR was -1.4 s(-1) and median strain -16.6%. In older control subjects, parameters differed only slightly. In acutely ischemic and scarred myocardium, both systolic strain and SR were significantly reduced or inverted. In disease, PSS occurred significantly more often (78% and 79%, respectively), was significantly higher in magnitude, and its peak occurred later than in young and older control subjects., Conclusion: PSS is a normal finding in healthy subjects occurring in approximately one-third of myocardial segments and, thus, is not always a marker of disease. Our data indicate that pathologic PSS can be detected by coexisting reduction in systolic strain and, second, by exceeding a postsystolic strain magnitude cutoff.
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- 2003
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16. Transradial approach for coronary angioplasty in the setting of acute myocardial infarction: a dual-center registry.
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Louvard Y, Ludwig J, Lefèvre T, Schmeisser A, Brück M, Scheinert D, Loubeyre C, Klinghammer L, Morice MC, Flachskampf FA, and Daniel WG
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- Aged, Blood Vessel Prosthesis Implantation instrumentation, Coronary Angiography, Female, Femoral Artery diagnostic imaging, Femoral Artery surgery, France epidemiology, Germany epidemiology, Humans, Incidence, Male, Middle Aged, Myocardial Infarction diagnostic imaging, Radial Artery diagnostic imaging, Registries, Stents, Treatment Outcome, Angioplasty, Balloon, Coronary, Myocardial Infarction therapy, Radial Artery surgery
- Abstract
Although transradial angioplasty has been shown to have no major entry site-related complications, its clinical applicability for balloon angioplasty and stenting in acute myocardial infarction (AMI) is unclear. In order to assess the feasibility, safety, and clinical outcome of transradial access for coronary angioplasty (PTCA) and stenting during AMI, transradial angioplasty for AMI was registered on a prospective database at two European sites (A and B) with experience in the radial approach (RA); 6 Fr catheters with an inner lumen of at least 0.064" and low-profile rapid-exchange balloons were used. Primary success rates and procedural complications of 6 Fr RA were determined and compared to 6 Fr femoral approach (FA) procedures. A total of 1,224 AMI patients entered the registry. Study site A enrolled 185 RA patients (13.6% AMI) and study site B 92 RA patients (63.4%). Patient baseline demographics were similar in both study centers and showed no differences between RA and FA patients, except a more frequent use of abciximab in study site B compared to A. PTCA was successful in > 95% of both RA and FA patients. Total procedural time did not differ between RA and FA patients. Severe access site-related bleeding complications, however, were observed in FA patients only: study site A used closure devices routinely and found 2% severe bleedings; study site B used no closure device for FA patients and observed 7% severe bleedings. In selected patients and in experienced hands, transradial PTCA in AMI has a high success rate, is clinically safe, and could become an attractive alternative access site for patients being at high or even low risk for bleeding complications., (Copyright 2002 Wiley-Liss, Inc.)
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- 2002
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17. Development, validation, and implementation of biomarker testing in cardiovascular medicine state-of-the-art: proceedings of the European Society of Cardiology—Cardiovascular Round Table.
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Elliott, Perry, Cowie, Martin R, Franke, Jennifer, Ziegler, André, Antoniades, Charalambos, Bax, Jeroen, Bucciarelli-Ducci, Chiara, Flachskampf, Frank A, Hamm, Christian, Jensen, Magnus T, Katus, Hugo, Maisel, Alan, McDonagh, Theresa, Mittmann, Clemens, Muntendam, Pieter, Nagel, Eike, Rosano, Giuseppe, Twerenbold, Raphael, and Zannad, Faiez
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CARDIAC magnetic resonance imaging ,BIOMARKERS - Abstract
Many biomarkers that could be used to assess ejection fraction, heart failure, or myocardial infarction fail to translate into clinical practice because they lack essential performance characteristics or fail to meet regulatory standards for approval. Despite their potential, new technologies have added to the complexities of successful translation into clinical practice. Biomarker discovery and implementation require a standardized approach that includes: identification of a clinical need; identification of a valid surrogate biomarker; stepwise assay refinement, demonstration of superiority over current standard-of-care; development and understanding of a clinical pathway; and demonstration of real-world performance. Successful biomarkers should improve efficacy or safety of treatment, while being practical at a realistic cost. Everyone involved in cardiovascular healthcare, including researchers, clinicians, and industry partners, are important stakeholders in facilitating the development and implementation of biomarkers. This article provides suggestions for a development pathway for new biomarkers, discusses regulatory issues and challenges, and suggestions for accelerating the pathway to improve patient outcomes. Real-life examples of successful biomarkers—high-sensitivity cardiac troponin, T2* cardiovascular magnetic resonance imaging, and echocardiography—are used to illustrate the value of a standardized development pathway in the translation of concepts into routine clinical practice. [ABSTRACT FROM AUTHOR]
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- 2021
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18. Changes in global longitudinal strain and left ventricular ejection fraction during the first year after myocardial infarction: results from a large consecutive cohort.
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Baron, Tomasz, Christersson, Christina, Hjorthén, Gustav, Hedin, Eva-Maria, and Flachskampf, Frank A
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ADRENERGIC beta blockers ,HEART ventricle diseases ,STATISTICAL correlation ,ECHOCARDIOGRAPHY ,LEFT heart ventricle ,HOSPITAL admission & discharge ,LONGITUDINAL method ,MYOCARDIAL infarction ,PATIENTS ,SEX distribution ,SMOKING ,VENTRICULAR remodeling ,STROKE volume (Cardiac output) ,VENTRICULAR ejection fraction - Abstract
Aims To determine changes of global longitudinal strain (GLS) and their predictors in relation to classical echocardiographic parameters of left ventricular (LV) function, over 1 year, in consecutive patients with myocardial infarction (MI) and initially normal or impaired LV ejection fraction (EF). Methods and results A total of 285 patients with MI prospectively included in the REBUS (RElevance of Biomarkers for future risk of thromb-oembolic events in UnSelected post-myocardial infarction patients) study underwent echocardiography within 72 h from admission and after 1 year. At baseline, 213 (74.7%) of MI patients had a normal EF (≥52% in men or ≥54% in women), but in 70.4% of them, an impaired GLS ( ≥ −18.0%) was observed. During 1-year follow-up, in patients with normal EF at baseline, GLS improved from −15.8% to − 17.4% (10.1% relative change); EF decreased from 62.5% to 59.9% (4.0% relative change); indexed end-diastolic volume, indexed end-systolic volume, and indexed stroke volume increased with 15.6%, 24.8%, and 10.0% of relative change, respectively (P < 0.001 for all the comparisons). In the whole cohort, initial impairment of LV function [by EF, wall motion score index (WMSI), or GLS], male gender, non-smoking, and treatment with beta-blockers were the independent predictors of GLS improvement. In the group with initially impaired EF, over 1 year GLS improved from −11.9% to − 14.8% (24.4% relative change) and EF from 44.6% to 52.6% (18.2% relative change) (P < 0.001 for both). Improvement in GLS significantly correlated with EF increase in the group with impaired EF (r = −0.41, P = 0.001) but not in the patients with normal EF (r = −0.14, P = ns). Conclusions Despite diveregent evolution of GLS compared with EF and ventricular volumes, one year after MI GLS significantly improved in patients with initially both normal and impaired EF. Initial impairment of LV function (by EF, WMSI, or GLS), male gender, non-smoking, and treatment with beta-blockers were independent predictors of GLS improvement. LV remodelling was present even in patients with normal EF at baseline and during follow-up, confirming limited functional assessment by EF alone. [ABSTRACT FROM AUTHOR]
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- 2018
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19. 2015 ESC Guidelines for the Diagnosis and Management of Pericardial Diseases
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Adler, Yehuda, Charron, Philippe, Imazio, Massimo, Badano, Luigi, Barón Esquivias, Gonzalo, Bogaert, Jan, Brucato, Antonio, Gueret, Pascal, Klingel, Karin, Lionis, Christos, Maisch, Bernhard, Mayosi, Bongani, Pavie, Alain, Ristić, Arsen D., Tenas, Manel Sabaté, Seferovic, Petar, Swedberg, Karl, Tomkowski, Witold, Achenbach, Stephan, Agewall, Stefan, Al Attar, Nawwar, Ferrer, Juan Angel, Arad, Michael, Asteggiano, Riccardo, Bueno, Héctor, Caforio, Alida L. P., Carerj, Scipione, Ceconi, Claudio, Evangelista, Arturo, Flachskampf, Frank, Giannakoulas, George, Gielen, Stephan, Habib, Gilbert, Kolh, Philippe, Lambrinou, Ekaterini, Lancellotti, Patrizio, Lazaros, George, Linhart, Ales, Meurin, Philippe, Nieman, Koen, Piepoli, Massimo F., Price, Susanna, Roos Hesselink, Jolien, Zamorano, Jose Luis, Aboyans, Victor, Badimon, Lina, Baumgartner, Helmut, Bax, Jeroen J., Dean, Veronica, Erol, Cetin, Fitzimons, Donna, Gaemperli, Oliver, Kirchhof, Paulus, Lip, Gregory Y. H., Nihoyannopoulos, Petros, Ponikowski, Piotr, Roffi, Marco, Torbicki, Adam, Carneiro, Antonio Vaz, Windecker, Stephan, Adler, Y, Charron, P, Imazio, M, Badano, L, Baron-Esquivias, G, Bogaert, J, Brucato, A, Gueret, P, Klingel, K, Lionis, C, Maisch, B, Mayosi, B, Pavie, A, Ristic, A, Tenas, M, Seferovic, P, Swedberg, K, Tomkowski, W, Achenbach, S, Agewall, S, Al-Attar, N, Ferrer, J, Arad, M, Asteggiano, R, Bueno, H, Caforio, A, Carerj, S, Ceconi, C, Evangelista, A, Flachskampf, F, Giannakoulas, G, Gielen, S, Habib, G, Kolh, P, Lambrinou, E, Lancellotti, P, Lazaros, G, Linhart, A, Meurin, P, Nieman, K, Piepoli, M, Price, S, Roos-Hesselink, J, Zamorano, J, Aboyans, V, Badimon, L, Baumgartner, H, Bax, J, Dean, V, Erol, C, Fitzimons, D, Gaemperli, O, Kirchhof, P, Lip, G, Nihoyannopoulos, P, Ponikowski, P, Roffi, M, Torbicki, A, Carneiro, A, and Windecker, S
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Male ,Cardiac Catheterization ,Pathology ,Multimodal Imaging ,Heart Neoplasms ,Kidney Failure ,Pericarditis ,Myocardial infarction ,Aetiology ,Chronic ,Tomography ,Societies, Medical ,Pericardiocentesis ,General Medicine ,Constrictive pericarditis ,Diagnosis ,Guidelines ,Myopericarditis ,Pericardial effusion ,Pericardium ,Prognosis ,Tamponade ,Therapy ,Cardiothoracic surgery ,Echocardiography ,Acute Disease ,Pericardial diseases ,cardiovascular system ,Drainage ,Antibody ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Congenital cytomegalovirus infection ,Guidelines, Aetiology, Constrictive pericarditis, Diagnosis, Myopericarditis, Pericardial effusion, Pericardiocentesis, Pericarditis, Pericardium, Prognosis, Tamponade, Therapy ,Text mining ,Humans ,Radiation Injuries ,Physical Examination ,medicine.disease ,Cardiac Tamponade ,Heart Injuries ,chemistry ,Positron-Emission Tomography ,Kidney Failure, Chronic ,Creatine kinase ,Triage ,Biomarkers ,Magnetic Resonance Angiography ,Biopsy ,Basic fibroblast growth factor ,Anti-Inflammatory Agents ,Medical and Health Sciences ,chemistry.chemical_compound ,Postoperative Complications ,Adenosine deaminase ,Recurrence ,reproductive and urinary physiology ,Age Factors ,Autoimmune Diseases ,Bacterial Infections ,Chronic Disease ,Endoscopy ,Hospitalization ,Sex Factors ,Syndrome ,Tomography, X-Ray Computed ,Treatment Outcome ,Virus Diseases ,Pericardial Effusion ,biology ,Medicine (all) ,Thoracic Surgery ,X-Ray Computed ,Europe ,medicine.anatomical_structure ,Infective endocarditis ,embryonic structures ,Cardiology ,Female ,biological phenomena, cell phenomena, and immunity ,Esc Guidelines ,Heart Diseases ,Acute pericarditis ,Internal medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,cardiovascular diseases ,urogenital system ,Task force ,business.industry ,RC666-701 ,biology.protein ,business - Abstract
ADA : adenosine deaminase AMI : acute myocardial infarction ANA : anti-nuclear antibody bFGF : basic fibroblast growth factor CK : creatine kinase CMR : cardiac magnetic resonance CMV : cytomegalovirus CP : Child–Pugh CRP : C-reactive protein CT : computed tomography EBV
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- 2015
20. Usefulness of traditional echocardiographic parameters in assessment of left ventricular function in patients with normal ejection fraction early after acute myocardial infarction: results from a large consecutive cohort.
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Baron, Tomasz, Flachskampf, Frank A., Johansson, Kristina, Hedin, Eva-Maria, and Christersson, Christina
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DOPPLER echocardiography ,LEFT heart ventricle ,HEART physiology ,MYOCARDIAL infarction ,REFERENCE values ,REGRESSION analysis ,STATISTICAL sampling ,T-test (Statistics) ,REPEATED measures design ,DESCRIPTIVE statistics ,VENTRICULAR ejection fraction - Abstract
Aims The aim of this study was to assess the frequency of left ventricular (LV) systolic function impairment using classical echocardiographic parameters and their relation to myocardial damage in patients hospitalized for acute myocardial infarction (MI) with normal LV ejection fraction (LVEF ≥52% in males or ≥54% in females). Methods and results All 421 consecutive patients with MI included in the REBUS (RElevance of Biomarkers for future risk of thrombo-embolic events in UnSelected post-myocardial infarction patients) study underwent two-dimensional and Doppler echocardiography within 72 h after admission. A normal LVEF was present in 262 (73.8%) of the 355 patients ultimately enrolled in the study. Patients with normal LVEF more often presented with non-ST-elevation myocardial infarction and had less comorbidities when compared with those with impaired LVEF. No differences in demographic factors or relevant medications were observed. Higher value of mean annular plane systolic excursion (MAPSE), lower wall motion score index (WMSI), lower LV as well as left atrial volumes characterized patients with normal LVEF. Impaired MAPSE was present in 64.4%, WMSI .1 in 72.1%, and dilated left atrium in 33.6% of those patients. Maximal cardiac troponin concentration reflecting infarct size showed the strongest association with WMSI (β = 0.35), followed by LVEF (β = 20.29), MAPSE (β = 20.25), and indexed LV end-systolic volume (β = 0.19; P, 0.001 for all the models). Conclusion In two-third of patients with MI and normal LVEF, at least one of the other markers of systolic function was outside of the normal range. WMSI reflected the size of MI better than global LV function parameters as LVEF or MAPSE. [ABSTRACT FROM AUTHOR]
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- 2016
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21. The use of echocardiography in acute cardiovascular care: Recommendations of the European Association of Cardiovascular Imaging and the Acute Cardiovascular Care Association.
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Lancellotti, Patrizio, Price, Susanna, Edvardsen, Thor, Cosyns, Bernard, Neskovic, Aleksandar N., Dulgheru, Raluca, Flachskampf, Frank A., Hassager, Christian, Pasquet, Agnes, Gargani, Luna, Galderisi, Maurizio, Cardim, Nuno, Haugaa, Kristina H., Ancion, Arnaud, Zamorano, Jose-Luis, Donal, Erwan, Bueno, Héctor, and Habib, Gilbert
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ENDOCARDITIS ,AORTIC diseases ,CARDIAC tamponade ,CARDIOVASCULAR system ,CARDIOVASCULAR disease diagnosis ,CHEST pain ,ECHOCARDIOGRAPHY ,HEART failure ,HEART valve diseases ,MEDICAL care ,MYOCARDIAL infarction ,ACUTE diseases - Abstract
Echocardiography is one of the most powerful diagnostic and monitoring tools available to the modern emergency/ critical care practitioner. Currently, there is a lack of specific European Association of Cardiovascular Imaging/Acute Cardiovascular Care Association recommendations for the use of echocardiography in acute cardiovascular care. In this document, we describe the practical applications of echocardiography in patients with acute cardiac conditions, in particular with acute chest pain, acute heart failure, suspected cardiac tamponade, complications of myocardial infarction, acute valvular heart disease including endocarditis, acute disease of the ascending aorta and post-intervention complications. Specific issues regarding echocardiography in other acute cardiovascular care scenarios are also described. [ABSTRACT FROM AUTHOR]
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- 2015
- Full Text
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22. Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American society of echocardiography and the European association of cardiovascular imaging
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Elyse Foster, Kirk T. Spencer, Denisa Muraru, Jonathan Afilalo, Roberto M. Lang, Tatiana Kuznetsova, Luigi P. Badano, Michael H. Picard, Steven A. Goldstein, Jens-Uwe Voigt, Laura Ernande, Anderson C. Armstrong, Wendy Tsang, Frank A. Flachskampf, Lawrence G. Rudski, Victor Mor-Avi, Patrizio Lancellotti, Ernst Rietzschel, Lang Roberto, M, Badano, L, Mor-Avi, V, Afilalo, J, Armstrong, A, Ernande, L, Flachskampf Frank, A, Foster, E, Goldstein Steven, A, Kuznetsova, T, Lancellotti, P, Muraru, D, Picard Michael, H, Rietzschel Ernst, R, Rudski, L, Spencer Kirk, T, Tsang, W, Voigt, J, Victor, M, and Retzschel Ernst, R
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Male ,Transthoracic echocardiography ,Ventricular Dysfunction, Right ,Left ,Echocardiography, Three-Dimensional ,Speckle tracking echocardiography ,PATIENTS GREATER-THAN-OR-EQUAL-TO-65 YEARS ,Doppler echocardiography ,Heart Ventricle ,Ventricular Dysfunction, Left ,Normal values ,Nuclear Medicine and Imaging ,Medicine and Health Sciences ,Ventricular Dysfunction ,LEFT ATRIAL VOLUME ,Myocardial infarction ,Societies, Medical ,Ejection fraction ,AORTIC-VALVE IMPLANTATION ,medicine.diagnostic_test ,Medicine (all) ,Doppler ,General Medicine ,Adult echocardiography ,Echocardiography, Doppler ,Europe ,Right ,medicine.vein ,Ventricular function ,Adult ,Female ,Forecasting ,Humans ,Sensitivity and Specificity ,United States ,Practice Guidelines as Topic ,Cardiology and Cardiovascular Medicine ,Radiology, Nuclear Medicine and Imaging ,Echocardiography ,Cardiology ,End-diastolic volume ,MULTIDETECTOR COMPUTED-TOMOGRAPHY ,Radiology ,Human ,TIME 3-DIMENSIONAL ECHOCARDIOGRAPHY ,United State ,SPECKLE-TRACKING ECHOCARDIOGRAPHY ,ACUTE MYOCARDIAL-INFARCTION ,medicine.medical_specialty ,Heart Ventricles ,Inferior vena cava ,GLOBAL LONGITUDINAL STRAIN ,Normal value ,LEFT-VENTRICULAR MASS ,Internal medicine ,Medical ,medicine ,Radiology, Nuclear Medicine and imaging ,Medical physics ,Societie ,End-systolic volume ,business.industry ,INFERIOR VENA-CAVA ,Stroke Volume ,medicine.disease ,Cardiac chamber ,Three-Dimensional ,business ,Societies - Abstract
The rapid technological developments of the past decade and the changes in echocardiographic practice brought about by these developments have resulted in the need for updated recommendations to the previously published guidelines for cardiac chamber quantification, which was the goal of the joint writing group assembled by the American Society of Echocardiography and the European Association of Cardiovascular Imaging. This document provides updated normal values for all four cardiac chambers, including three-dimensional echocardiography and myocardial deformation, when possible, on the basis of considerably larger numbers of normal subjects, compiled from multiple databases. In addition, this document attempts to eliminate several minor discrepancies that existed between previously published guidelines. ispartof: Journal of the American Society of Echocardiography vol:28 issue:1 pages:1-39 ispartof: location:United States status: published
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- 2015
23. The use of echocardiography in acute cardiovascular care: recommendations of the European Association of Cardiovascular Imaging and the Acute Cardiovascular Care Association
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Arnaud Ancion, Bernard Cosyns, Luna Gargani, Nuno Cardim, Susanna Price, Christian Hassager, Aleksandar Neskovic, Maurizio Galderisi, Gilbert Habib, Raluca Elena Dulgheru, Erwan Donal, Agnes Pasquet, José Luis Zamorano, Kristina H. Haugaa, Thor Edvardsen, Héctor Bueno, Patrizio Lancellotti, Frank A. Flachskampf, Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA-Research), Université de Liège, Department of Cardiology, Copenhagen University Hospital-Rigshospitalet [Copenhagen], Copenhagen University Hospital, University of Naples Federico II = Università degli studi di Napoli Federico II, Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospital General Universitario 'Gregorio Marañón' [Madrid], Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Groupe Interdisciplinaire de Génoprotéomique Appliquée ( GIGA-Research ), Université de Liège-Faculté de médecine vétérinaire, Università degli studi di Napoli Federico II, Service de cardiologie et maladies vasculaires, Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image ( LTSI ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes ( URMITE ), Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR48, INSB-INSB-Centre National de la Recherche Scientifique ( CNRS ), Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille ( APHM ) - Hôpital de la Timone [CHU - APHM] ( TIMONE ), Clinical sciences, Cardio-vascular diseases, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Jonchère, Laurent, Lancellotti, Patrizio, Price, Susanna, Edvardsen, Thor, Cosyns, Bernard, Neskovic, Aleksandar N, Dulgheru, Raluca, Flachskampf, Frank A, Hassager, Christian, Pasquet, Agne, Gargani, Luna, Galderisi, Maurizio, Cardim, Nuno, Haugaa, Kristina H, Ancion, Arnaud, Zamorano, Jose Lui, Donal, Erwan, Bueno, Héctor, Habib, Gilbert, and Cardiology
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medicine.medical_specialty ,Critical Care ,Heart Diseases ,Critical Illness ,Cardiovascular care ,Disease ,Recommendations ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,Acute cardiovascular care ,03 medical and health sciences ,critically ill patient ,0302 clinical medicine ,Critically ill patients ,Cardiac tamponade ,medicine.artery ,Ascending aorta ,Endocarditis ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Myocardial infarction ,[ SDV.IB ] Life Sciences [q-bio]/Bioengineering ,030212 general & internal medicine ,Intensive care medicine ,[SDV.IB] Life Sciences [q-bio]/Bioengineering ,business.industry ,valvular heart disease ,General Medicine ,medicine.disease ,3. Good health ,Europe ,Cardiovascular Diseases ,Echocardiography ,Heart failure ,Acute Disease ,cardiovascular system ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Clinical Competence ,Cardiology and Cardiovascular Medicine ,business - Abstract
International audience; Echocardiography is one of the most powerful diagnostic and monitoring tools available to the modern emergency/ critical care practitioner. Currently, there is a lack of specific European Association of Cardiovascular Imaging/Acute Cardiovascular Care Association recommendations for the use of echocardiography in acute cardiovascular care. In this document, we describe the practical applications of echocardiography in patients with acute cardiac conditions, in particular with acute chest pain, acute heart failure, suspected cardiac tamponade, complications of myocardial infarction, acute valvular heart disease including endocarditis, acute disease of the ascending aorta and post-intervention complications. Specific issues regarding echocardiography in other acute cardiovascular care scenarios are also described
- Published
- 2014
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